Article: Treatment of non-erosive reflux disease with a proton pump inhibitor in Chinese patients: A randomized controlled trial

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TitleTreatment of non-erosive reflux disease with a proton pump inhibitor in Chinese patients: A randomized controlled trial
AuthorsTan, VPY1
Wong, WM1
Cheung, TK1
Lai, KC1
Hung, IFN1
Chan, P1
Pang, R1
Wong, BCY1
KeywordsClinical trial
GERD
Proton pump inhibitor
Issue Date2011
PublisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htm
CitationJournal Of Gastroenterology, 2011, v. 46 n. 7, p. 906-912 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00535-011-0402-1
AbstractBackground: Evidence suggests that rates of gastroesophageal reflux disease are increasing in the Asia-Pacific region, where patients tend to have predominantly non-erosive reflux disease as opposed to erosive (reflux) esophagitis. At present, data for the responsiveness of non-erosive reflux disease to proton pump inhibition are scant. We aimed to study esomeprazole for the treatment of non-erosive reflux disease in Chinese patients. Methods: Patients with a clinical diagnosis of gastroesophageal reflux, and a locally validated reflux index, the Chinese GerdQ, of equal to or greater than 12 were recruited and randomized to receive esomeprazole 20 mg daily or placebo for 8 weeks. Reflux index scores, quality of life (SF-36), and the hospital anxiety and depression (HAD) scale and symptom relief were evaluated before, during, and after treatment. Results: A total of 175 patients were randomized. Patients in the esomeprazole group (n = 85) demonstrated statistically significant reductions in their GerdQ index, from 19.45 to 15.37 and to 14.32 (p = 0.013, p = 0.005) at weeks 4 and 8, respectively. Compared to placebo at week 8, 57.1% of patients on esomeprazole found that their symptoms had resolved or were acceptable compared with 37.2% in the placebo group (p = 0.001). There were no statistically significant differences in overall quality-of-life measures or the HAD scale related to treatment. Conclusions: This study suggests that esomeprazole is efficacious in treating Chinese patients with non-erosive reflux disease. © 2011 Springer.
ISSN0944-1174
2011 Impact Factor: 4.16
2011 SCImago Journal Rankings: 0.372
DOIhttp://dx.doi.org/10.1007/s00535-011-0402-1
ISI Accession Number IDWOS:000292607300006
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

We thank AstraZeneca Hong Kong for the supply of the study medicine and the identical placebo tablets. The study was supported by the Simon KY Lee Endowment Professorship, and the outstanding researcher award 2005-2006 of the University of Hong Kong.

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTan, VPY
dc.contributor.authorWong, WM
dc.contributor.authorCheung, TK
dc.contributor.authorLai, KC
dc.contributor.authorHung, IFN
dc.contributor.authorChan, P
dc.contributor.authorPang, R
dc.contributor.authorWong, BCY
dc.date.accessioned2011-09-23T05:50:42Z
dc.date.available2011-09-23T05:50:42Z
dc.date.issued2011
dc.description.abstractBackground: Evidence suggests that rates of gastroesophageal reflux disease are increasing in the Asia-Pacific region, where patients tend to have predominantly non-erosive reflux disease as opposed to erosive (reflux) esophagitis. At present, data for the responsiveness of non-erosive reflux disease to proton pump inhibition are scant. We aimed to study esomeprazole for the treatment of non-erosive reflux disease in Chinese patients. Methods: Patients with a clinical diagnosis of gastroesophageal reflux, and a locally validated reflux index, the Chinese GerdQ, of equal to or greater than 12 were recruited and randomized to receive esomeprazole 20 mg daily or placebo for 8 weeks. Reflux index scores, quality of life (SF-36), and the hospital anxiety and depression (HAD) scale and symptom relief were evaluated before, during, and after treatment. Results: A total of 175 patients were randomized. Patients in the esomeprazole group (n = 85) demonstrated statistically significant reductions in their GerdQ index, from 19.45 to 15.37 and to 14.32 (p = 0.013, p = 0.005) at weeks 4 and 8, respectively. Compared to placebo at week 8, 57.1% of patients on esomeprazole found that their symptoms had resolved or were acceptable compared with 37.2% in the placebo group (p = 0.001). There were no statistically significant differences in overall quality-of-life measures or the HAD scale related to treatment. Conclusions: This study suggests that esomeprazole is efficacious in treating Chinese patients with non-erosive reflux disease. © 2011 Springer.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Gastroenterology, 2011, v. 46 n. 7, p. 906-912 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00535-011-0402-1
dc.identifier.citeulike9264538
dc.identifier.doihttp://dx.doi.org/10.1007/s00535-011-0402-1
dc.identifier.epage912
dc.identifier.hkuros196569
dc.identifier.hkuros203200
dc.identifier.isiWOS:000292607300006
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

We thank AstraZeneca Hong Kong for the supply of the study medicine and the identical placebo tablets. The study was supported by the Simon KY Lee Endowment Professorship, and the outstanding researcher award 2005-2006 of the University of Hong Kong.

dc.identifier.issn0944-1174
2011 Impact Factor: 4.16
2011 SCImago Journal Rankings: 0.372
dc.identifier.issue7
dc.identifier.openurl
dc.identifier.pmid21538030
dc.identifier.scopuseid_2-s2.0-79960319148
dc.identifier.spage906
dc.identifier.urihttp://hdl.handle.net/10722/139500
dc.identifier.volume46
dc.languageeng
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htm
dc.publisher.placeJapan
dc.relation.ispartofJournal of Gastroenterology
dc.relation.referencesReferences in Scopus
dc.rightsThe original publication is available at www.springerlink.com
dc.subject.meshAnxiety
dc.subject.meshDouble-Blind Method
dc.subject.meshGastroesophageal Reflux - drug therapy - psychology
dc.subject.meshOmeprazole - therapeutic use
dc.subject.meshProton Pump Inhibitors - therapeutic use
dc.subjectClinical trial
dc.subjectGERD
dc.subjectProton pump inhibitor
dc.titleTreatment of non-erosive reflux disease with a proton pump inhibitor in Chinese patients: A randomized controlled trial
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong