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Article: Comparison of laboratory diagnostic methods for measles infection and identification of measles virus genotypes in Hong Kong

TitleComparison of laboratory diagnostic methods for measles infection and identification of measles virus genotypes in Hong Kong
Authors
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal of Medical Virology, 2010, v. 82 n. 10, p. 1773–1781 How to Cite?
AbstractThe sensitivities of IgM detection, virus isolation, and RT-PCR for the diagnosis of measles infection were assessed using samples collected from confirmed measles cases from 2006 to 2009. The optimal timing of specimen collection and the preferred specimen type(s) for these tests were also determined. IgM detection showed highest sensitivity when serum samples were collected >or=5 days after rash onset. Virus isolation gave the highest sensitivity when samples were collected
Persistent Identifierhttp://hdl.handle.net/10722/139484
ISSN
2015 Impact Factor: 1.998
2015 SCImago Journal Rankings: 1.015
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWoo, GKSen_US
dc.contributor.authorWong, AHen_US
dc.contributor.authorLee, WYen_US
dc.contributor.authorLau, WCSen_US
dc.contributor.authorCheng, PKCen_US
dc.contributor.authorLeung, PCKen_US
dc.contributor.authorLim, WWLen_US
dc.date.accessioned2011-09-23T05:50:34Z-
dc.date.available2011-09-23T05:50:34Z-
dc.date.issued2010en_US
dc.identifier.citationJournal of Medical Virology, 2010, v. 82 n. 10, p. 1773–1781en_US
dc.identifier.issn0146-6615-
dc.identifier.urihttp://hdl.handle.net/10722/139484-
dc.description.abstractThe sensitivities of IgM detection, virus isolation, and RT-PCR for the diagnosis of measles infection were assessed using samples collected from confirmed measles cases from 2006 to 2009. The optimal timing of specimen collection and the preferred specimen type(s) for these tests were also determined. IgM detection showed highest sensitivity when serum samples were collected >or=5 days after rash onset. Virus isolation gave the highest sensitivity when samples were collected <or=3 days after rash onset, with nasopharyngeal aspirate being the best specimen type, followed by urine and throat/combined throat and nasal swab. The highest RT-PCR positive rate (81.0%) was obtained with serum samples collected <or=3 days after rash onset. RT-PCR positive rate of 100% was observed with throat/combined throat and nasal swab, urine and nasopharyngeal aspirate collected <or=16, 4-16, and 4-7 days after rash onset, respectively. The genotype of each measles case was confirmed by sequencing. It was shown that the predominant measles viruses detected in Hong Kong during 2006-2009 belonged to genotype H1 (subtype a) and these strains were related closely to those detected in China.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763-
dc.relation.ispartofJournal of Medical Virologyen_US
dc.rightsJournal of Medical Virology. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshAntibodies, Viral - blood-
dc.subject.meshClinical Laboratory Techniques - methods-
dc.subject.meshMeasles - diagnosis - virology-
dc.subject.meshMeasles virus - classification - genetics - isolation and purification-
dc.subject.meshVirology - methods-
dc.titleComparison of laboratory diagnostic methods for measles infection and identification of measles virus genotypes in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailLau, WCS: cslau@hku.hken_US
dc.identifier.authorityLau, WCS=rp01348en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmv.21888-
dc.identifier.pmid20827776-
dc.identifier.scopuseid_2-s2.0-77956574897-
dc.identifier.hkuros195390en_US
dc.identifier.volume82en_US
dc.identifier.issue10en_US
dc.identifier.spage1773–1781en_US
dc.identifier.epage1773–1781en_US
dc.identifier.isiWOS:000281081000020-
dc.publisher.placeUnited States-

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