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Article: Fish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with Type 2 diabetes mellitus

TitleFish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with Type 2 diabetes mellitus
Authors
KeywordsDiabetes
Fish oil
Renal function
Vascular function
Issue Date2010
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DME
Citation
Diabetic Medicine, 2010, v. 27 n. 1, p. 54-60 How to Cite?
AbstractAims: Increased dietary fish-oil consumption is associated with a reduced risk of coronary heart events and has pronounced effects on dyslipidaemia. However, the effects of fish-oil supplement on vascular function and metabolic profile in patients with Type 2 diabetes mellitus (DM) are unclear. Methods In a double-blind placebo-controlled trial, we randomized 97 Type 2 DM patients without prior cardiovascular disease to fish-oil (4 g/day, n = 49) or olive-oil (with equivalent calories, as placebo, n = 48) supplements for 12 weeks. Assessment of vascular function with brachial artery flow-mediated dilation (FMD) and circulating levels of endothelial progenitor cells (EPCs), and metabolic parameters, high-sensitivity C-reactive protein (hsCRP), oxidative stress markers and renal function were examined before and after the supplement. Results Despite a significant reduction in serum triglycerides (-0.47 mmol/l, P < 0.01), 12-week supplement of fish oil did not improve vascular function as determined by FMD (+0.16%, P = 0.83) and circulating EPC count (+4 cells/μl, P = 0.78). Furthermore, fish-oil supplement did not have any significant treatment effects on hsCRP, oxidative stress, low- and high-density lipoprotein and glycated haemoglobin (HbA1c) (all P > 0.05). In contrast, serum creatinine was lower (-4.5 μmol/l, P = 0.01) in fish-oil-treated patients as compared with control subjects. Conclusions This study demonstrated that 12 weeks of fish-oil supplement had no significant beneficial effect on vascular endothelial function, but improved renal function without changes in endothelial function, metabolic profiles, blood pressure, inflammation or oxidative stress in patients with Type 2 DM. © 2010 Diabetes UK.
Persistent Identifierhttp://hdl.handle.net/10722/139461
ISSN
2015 Impact Factor: 3.152
2015 SCImago Journal Rankings: 1.654
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, CYen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorLee, Sen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.issued2010en_HK
dc.identifier.citationDiabetic Medicine, 2010, v. 27 n. 1, p. 54-60en_HK
dc.identifier.issn0742-3071en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139461-
dc.description.abstractAims: Increased dietary fish-oil consumption is associated with a reduced risk of coronary heart events and has pronounced effects on dyslipidaemia. However, the effects of fish-oil supplement on vascular function and metabolic profile in patients with Type 2 diabetes mellitus (DM) are unclear. Methods In a double-blind placebo-controlled trial, we randomized 97 Type 2 DM patients without prior cardiovascular disease to fish-oil (4 g/day, n = 49) or olive-oil (with equivalent calories, as placebo, n = 48) supplements for 12 weeks. Assessment of vascular function with brachial artery flow-mediated dilation (FMD) and circulating levels of endothelial progenitor cells (EPCs), and metabolic parameters, high-sensitivity C-reactive protein (hsCRP), oxidative stress markers and renal function were examined before and after the supplement. Results Despite a significant reduction in serum triglycerides (-0.47 mmol/l, P < 0.01), 12-week supplement of fish oil did not improve vascular function as determined by FMD (+0.16%, P = 0.83) and circulating EPC count (+4 cells/μl, P = 0.78). Furthermore, fish-oil supplement did not have any significant treatment effects on hsCRP, oxidative stress, low- and high-density lipoprotein and glycated haemoglobin (HbA1c) (all P > 0.05). In contrast, serum creatinine was lower (-4.5 μmol/l, P = 0.01) in fish-oil-treated patients as compared with control subjects. Conclusions This study demonstrated that 12 weeks of fish-oil supplement had no significant beneficial effect on vascular endothelial function, but improved renal function without changes in endothelial function, metabolic profiles, blood pressure, inflammation or oxidative stress in patients with Type 2 DM. © 2010 Diabetes UK.en_HK
dc.languageeng-
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DMEen_HK
dc.relation.ispartofDiabetic Medicineen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectDiabetesen_HK
dc.subjectFish oilen_HK
dc.subjectRenal functionen_HK
dc.subjectVascular functionen_HK
dc.subject.meshBrachial Artery - drug effects - physiopathology-
dc.subject.meshCardiovascular Diseases - drug therapy - physiopathology-
dc.subject.meshDiabetes Mellitus, Type 2 - drug therapy - physiopathology-
dc.subject.meshFatty Acids, Omega-3 - therapeutic use-
dc.subject.meshRenal Artery - drug effects - physiopathology-
dc.titleFish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with Type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1464-5491.2009.02869.xen_HK
dc.identifier.pmid20121889-
dc.identifier.scopuseid_2-s2.0-73949099366en_HK
dc.identifier.hkuros194353-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-73949099366&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue1en_HK
dc.identifier.spage54en_HK
dc.identifier.epage60en_HK
dc.identifier.isiWOS:000273451900008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, CY=25947838400en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridLee, S=27169452400en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike6535927-

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