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Article: Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China

TitleHeterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China
Authors
Issue Date2011
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2011, v. 34 n. 7, p. 1639-1641 How to Cite?
AbstractOBJECTIVE - To determine the relationship between selected cytokines and diabetes in Chinese subjects. RESEARCH DESIGN AND METHODS - Adult patients with recent-onset type 1 diabetes (n = 53), latent autoimmune diabetes in adults (LADA) (n = 250), and type 2 diabetes (n= 285) from multiple centers were compared with normal subjects (n = 196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin 2 (LCN2), high-sensitivity C-reactive protein (hs-CRP), and adiponectin. RESULTS - After adjustment for age, sex, and BMI, all diabetes types had increased IL-6 and LCN2 (P < 0.01), and all four cytokines were increased in LADA (P < 0.01). In type 1 diabetes, adiponectin but not hs-CRP was increased (P < 0.01), whereas in type 2 diabetes, hs-CRP but not adiponectin was increased (P < 0.01). Adiponectin was correlated positively with GADA titer and negatively with hs-CRP (P < 0.01 for both). CONCLUSIONS - In China, inflammatory markers are increased in all three major types of diabetes, but probably for different reasons, even in autoimmune diabetes. © 2011 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/139456
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
European Foundation for the Study of Diabetes (EFSD)
Bristol-Myers Squibb Company
Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
National Science Foundation30831160518
Funding Information:

This study was supported by the European Foundation for the Study of Diabetes (EFSD) grant awards for collaborative diabetes research between China and Europe supported by Bristol-Myers Squibb Company, by the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, and by the National Science Foundation grant for collaboration between Hong Kong and mainland China (30831160518). No other potential conflicts of interest relevant to this article were reported.

References

 

DC FieldValueLanguage
dc.contributor.authorXiang, Yen_HK
dc.contributor.authorZhou, Pen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorHuang, Gen_HK
dc.contributor.authorLiu, Zen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorLeslie, RDen_HK
dc.contributor.authorZhou, Zen_HK
dc.date.accessioned2011-09-23T05:50:17Z-
dc.date.available2011-09-23T05:50:17Z-
dc.date.issued2011en_HK
dc.identifier.citationDiabetes Care, 2011, v. 34 n. 7, p. 1639-1641en_HK
dc.identifier.issn0149-5992en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139456-
dc.description.abstractOBJECTIVE - To determine the relationship between selected cytokines and diabetes in Chinese subjects. RESEARCH DESIGN AND METHODS - Adult patients with recent-onset type 1 diabetes (n = 53), latent autoimmune diabetes in adults (LADA) (n = 250), and type 2 diabetes (n= 285) from multiple centers were compared with normal subjects (n = 196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin 2 (LCN2), high-sensitivity C-reactive protein (hs-CRP), and adiponectin. RESULTS - After adjustment for age, sex, and BMI, all diabetes types had increased IL-6 and LCN2 (P < 0.01), and all four cytokines were increased in LADA (P < 0.01). In type 1 diabetes, adiponectin but not hs-CRP was increased (P < 0.01), whereas in type 2 diabetes, hs-CRP but not adiponectin was increased (P < 0.01). Adiponectin was correlated positively with GADA titer and negatively with hs-CRP (P < 0.01 for both). CONCLUSIONS - In China, inflammatory markers are increased in all three major types of diabetes, but probably for different reasons, even in autoimmune diabetes. © 2011 by the American Diabetes Association.en_HK
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_HK
dc.relation.ispartofDiabetes Careen_HK
dc.subject.meshAcute-Phase Proteins-
dc.subject.meshAdiponectin - blood-
dc.subject.meshCytokines - blood-
dc.subject.meshDiabetes Mellitus, Type 1 - blood-
dc.subject.meshDiabetes Mellitus, Type 2 - blood-
dc.titleHeterogeneity of altered cytokine levels across the clinical spectrum of diabetes in Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0149-5992&volume=34&issue=7&spage=1639&epage=1641&date=2011&atitle=Heterogeneity+of+altered+cytokine+levels+across+the+clinical+spectrum+of+diabetes+in+Chinaen_US
dc.identifier.emailXu, A:amxu@hkucc.hku.hken_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.2337/dc11-0039en_HK
dc.identifier.pmid21617097-
dc.identifier.pmcidPMC3120206-
dc.identifier.scopuseid_2-s2.0-80054686647en_HK
dc.identifier.hkuros194042en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054686647&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1639en_HK
dc.identifier.epage1641en_HK
dc.identifier.isiWOS:000293261200038-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXiang, Y=53664848800en_HK
dc.identifier.scopusauthoridZhou, P=36907819100en_HK
dc.identifier.scopusauthoridLi, X=53663949200en_HK
dc.identifier.scopusauthoridHuang, G=7403425062en_HK
dc.identifier.scopusauthoridLiu, Z=53664121300en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridLeslie, RD=35459934500en_HK
dc.identifier.scopusauthoridZhou, Z=8417885800en_HK

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