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Article: Surface modification of three-dimensional Ca-P/PHBV nanocomposite scaffolds by physical entrapment of gelatin and its in vitro biological evaluation

TitleSurface modification of three-dimensional Ca-P/PHBV nanocomposite scaffolds by physical entrapment of gelatin and its in vitro biological evaluation
Authors
Keywordscell behaviour
nanocomposite scaffold
physical entrapment
selective laser sintering
surface modification
Issue Date2011
PublisherHigher Education Press and Springer-Verlag Berlin. The Journal's web site is located at http://www.springer.com/materials/journal/11706
Citation
Frontiers Of Materials Science In China, 2011, v. 5 n. 1, p. 57-68 How to Cite?
AbstractThe properties of bone tissue engineering scaffolds such as architecture, porosity, mechanical properties and surface properties have significant effects on cellular response and play an important role in bone regeneration. In this study, threedimensional nanocomposite scaffolds consisting of calcium phosphate (Ca-P) nanoparticles and poly (SLS), one of the versatile rapid prototyping techniques. The Ca-P/PHBV nanocomposite scaffolds had a porosity of (61.75±1.24)%, compressive strength of (2.16±0.21) MPa and Young's modulus of (26.98±2.29) MPa. The surface modification of scaffolds by gelatin was achieved through physical entrapment. The amount of entrapped gelatin could be controlled by varying the solvent composition and reaction time. The surface modification improved the hydrophilicity of scaffolds but did not significantly affect the surface morphology and mechanical properties. Osteoblast-like cells (SaOS-2) were cultured on scaffolds with and without gelatin surface modification. The majority of SaOS-2 cells were viable and proliferated in both types of scaffolds for up to 14 d in culture, as indicated by MTT assay and live and dead assay. Surface modification significantly increased cell proliferation for surface modified scaffolds, which could be due to the improvement in hydrophilicity of the scaffolds. © 2011 Higher Education Press and Springer-Verlag Berlin Heidelberg.
Persistent Identifierhttp://hdl.handle.net/10722/139390
ISSN
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDuan, Ben_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorLi, ZYen_HK
dc.contributor.authorChan, WCen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2011-09-23T05:49:05Z-
dc.date.available2011-09-23T05:49:05Z-
dc.date.issued2011en_HK
dc.identifier.citationFrontiers Of Materials Science In China, 2011, v. 5 n. 1, p. 57-68en_HK
dc.identifier.issn1673-7377en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139390-
dc.description.abstractThe properties of bone tissue engineering scaffolds such as architecture, porosity, mechanical properties and surface properties have significant effects on cellular response and play an important role in bone regeneration. In this study, threedimensional nanocomposite scaffolds consisting of calcium phosphate (Ca-P) nanoparticles and poly (SLS), one of the versatile rapid prototyping techniques. The Ca-P/PHBV nanocomposite scaffolds had a porosity of (61.75±1.24)%, compressive strength of (2.16±0.21) MPa and Young's modulus of (26.98±2.29) MPa. The surface modification of scaffolds by gelatin was achieved through physical entrapment. The amount of entrapped gelatin could be controlled by varying the solvent composition and reaction time. The surface modification improved the hydrophilicity of scaffolds but did not significantly affect the surface morphology and mechanical properties. Osteoblast-like cells (SaOS-2) were cultured on scaffolds with and without gelatin surface modification. The majority of SaOS-2 cells were viable and proliferated in both types of scaffolds for up to 14 d in culture, as indicated by MTT assay and live and dead assay. Surface modification significantly increased cell proliferation for surface modified scaffolds, which could be due to the improvement in hydrophilicity of the scaffolds. © 2011 Higher Education Press and Springer-Verlag Berlin Heidelberg.en_HK
dc.languageengen_US
dc.publisherHigher Education Press and Springer-Verlag Berlin. The Journal's web site is located at http://www.springer.com/materials/journal/11706en_US
dc.relation.ispartofFrontiers of Materials Science in Chinaen_HK
dc.subjectcell behaviouren_HK
dc.subjectnanocomposite scaffolden_HK
dc.subjectphysical entrapmenten_HK
dc.subjectselective laser sinteringen_HK
dc.subjectsurface modificationen_HK
dc.titleSurface modification of three-dimensional Ca-P/PHBV nanocomposite scaffolds by physical entrapment of gelatin and its in vitro biological evaluationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=2095-025X&volume=5&issue=1&spage=57&epage=68&date=2011&atitle=Surface+modification+of+three-dimensional+Ca-P/PHBV+nanocomposite+scaffolds+by+physical+entrapment+of+gelatin+and+its+In+vitro+biological+evaluation-
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11706-011-0101-0en_HK
dc.identifier.scopuseid_2-s2.0-79952721140en_HK
dc.identifier.hkuros193983en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952721140&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue1en_HK
dc.identifier.spage57en_HK
dc.identifier.epage68en_HK
dc.identifier.isiWOS:000208935400005-
dc.identifier.scopusauthoridDuan, B=7005042335en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK
dc.identifier.scopusauthoridLi, ZY=35727919500en_HK
dc.identifier.scopusauthoridChan, WC=36503653500en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.citeulike7937607-

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