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Article: Optimized fabrication of Ca-P/PHBV nanocomposite scaffolds via selective laser sintering for bone tissue engineering

TitleOptimized fabrication of Ca-P/PHBV nanocomposite scaffolds via selective laser sintering for bone tissue engineering
Authors
Issue Date2011
PublisherInstitute of Physics Publishing Ltd.. The Journal's web site is located at http://www.iop.org/EJ/journal/bf
Citation
Biofabrication, 2011, v. 3 n. 1 How to Cite?
AbstractBiomaterials for scaffolds and scaffold fabrication techniques are two key elements in scaffold-based tissue engineering. Nanocomposites that consist of biodegradable polymers and osteoconductive bioceramic nanoparticles and advanced scaffold manufacturing techniques, such as rapid prototyping (RP) technologies, have attracted much attention for developing new bone tissue engineering strategies. In the current study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) microspheres and calcium phosphate (Ca-P)/PHBV nanocomposite microspheres were fabricated using the oil-in-water (O/W) and solid-in-oil-in-water (S/O/W) emulsion solvent evaporation methods. The microspheres with suitable sizes were then used as raw materials for scaffold fabrication via selective laser sintering (SLS), which is a mature RP technique. A three-factor three-level complete factorial design was applied to investigate the effects of the three factors (laser power, scan spacing, and layer thickness) in SLS and to optimize SLS parameters for producing good-quality PHBV polymer scaffolds and Ca-P/PHBV nanocomposite scaffolds. The plots of the main effects of these three factors and the three-dimensional response surface were constructed and discussed. Based on the regression equation, optimized PHBV scaffolds and Ca-P/PHBV scaffolds were fabricated using the optimized values of SLS parameters. Characterization of optimized PHBV scaffolds and Ca-P/PHBV scaffolds verified the optimization process. It has also been demonstrated that SLS has the capability of constructing good-quality, sophisticated porous structures of complex shape, which some tissue engineering applications may require. © 2011 IOP Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/139388
ISSN
2015 Impact Factor: 4.702
2015 SCImago Journal Rankings: 1.505
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong (HKU)
Hong Kong Research Grants CouncilHKU 7182/05E
Funding Information:

BD thanks the University of Hong Kong (HKU) for making an award of the University Scholarship Award to him. This work was supported by an HKU research grant and by a GRF grant (HKU 7182/05E) from the Hong Kong Research Grants Council. Dr W-Y Zhou is thanked for his assistance in the project. Assistance provided by technical staff in the Department of Mechanical Engineering, HKU, is acknowledged.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorDuan, Ben_HK
dc.contributor.authorCheung, WLen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2011-09-23T05:49:04Z-
dc.date.available2011-09-23T05:49:04Z-
dc.date.issued2011en_HK
dc.identifier.citationBiofabrication, 2011, v. 3 n. 1en_HK
dc.identifier.issn1758-5082en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139388-
dc.description.abstractBiomaterials for scaffolds and scaffold fabrication techniques are two key elements in scaffold-based tissue engineering. Nanocomposites that consist of biodegradable polymers and osteoconductive bioceramic nanoparticles and advanced scaffold manufacturing techniques, such as rapid prototyping (RP) technologies, have attracted much attention for developing new bone tissue engineering strategies. In the current study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) microspheres and calcium phosphate (Ca-P)/PHBV nanocomposite microspheres were fabricated using the oil-in-water (O/W) and solid-in-oil-in-water (S/O/W) emulsion solvent evaporation methods. The microspheres with suitable sizes were then used as raw materials for scaffold fabrication via selective laser sintering (SLS), which is a mature RP technique. A three-factor three-level complete factorial design was applied to investigate the effects of the three factors (laser power, scan spacing, and layer thickness) in SLS and to optimize SLS parameters for producing good-quality PHBV polymer scaffolds and Ca-P/PHBV nanocomposite scaffolds. The plots of the main effects of these three factors and the three-dimensional response surface were constructed and discussed. Based on the regression equation, optimized PHBV scaffolds and Ca-P/PHBV scaffolds were fabricated using the optimized values of SLS parameters. Characterization of optimized PHBV scaffolds and Ca-P/PHBV scaffolds verified the optimization process. It has also been demonstrated that SLS has the capability of constructing good-quality, sophisticated porous structures of complex shape, which some tissue engineering applications may require. © 2011 IOP Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherInstitute of Physics Publishing Ltd.. The Journal's web site is located at http://www.iop.org/EJ/journal/bfen_HK
dc.relation.ispartofBiofabricationen_HK
dc.rightsBiofabrication. Copyright © Institute of Physics Publishing Ltd..en_US
dc.subject.meshBone Development-
dc.subject.meshNanocomposites - chemistry-
dc.subject.meshPolyesters - chemistry-
dc.subject.meshTissue Engineering - instrumentation-
dc.subject.meshTissue Scaffolds - chemistry-
dc.titleOptimized fabrication of Ca-P/PHBV nanocomposite scaffolds via selective laser sintering for bone tissue engineeringen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1758-5082&volume=3&issue=1, article no. 015001&spage=&epage=&date=2011&atitle=Optimized+fabrication+of+Ca-P/PHBV+nanocomposite+scaffolds+via+selective+laser+sintering+for+bone+tissue+engineering-
dc.identifier.emailCheung, WL:wlcheung@hkucc.hku.hken_HK
dc.identifier.authorityCheung, WL=rp00103en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1088/1758-5082/3/1/015001en_HK
dc.identifier.pmid21245522-
dc.identifier.scopuseid_2-s2.0-79958287550en_HK
dc.identifier.hkuros193979en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79958287550&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue1en_HK
dc.identifier.eissn1758-5090-
dc.identifier.isiWOS:000288025100002-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectBioactive and biodegradable composites for bone tissue repair-
dc.identifier.scopusauthoridDuan, B=7005042335en_HK
dc.identifier.scopusauthoridCheung, WL=7202743084en_HK
dc.identifier.scopusauthoridWang, M=36077223400en_HK

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