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Article: Controlled release of BSA by microsphere-incorporated PLGA scaffolds under cyclic loading

TitleControlled release of BSA by microsphere-incorporated PLGA scaffolds under cyclic loading
Authors
KeywordsBSA
Cyclic loading
Microsphere
Release
Scaffold
Issue Date2011
PublisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/msec
Citation
Materials Science And Engineering C, 2011, v. 31 n. 2, p. 350-356 How to Cite?
AbstractLocalized delivery of bioactive molecules from porous biodegradable scaffolds is very important in advanced tissue engineering strategies, and it is necessary to study the delivery under dynamic loading which mimics the in vivo biomechanical environments. In this study, bovine serum albumin (BSA), a model of bioactive proteins, was incorporated into porous poly(l-lactide-co-glycolide) (PLGA) scaffolds by seeding BSA-loaded microspheres onto the scaffold pore wall, where the microspheres of poly(ethylene glycol)-b-poly(l-lactide) (PELA) were prepared by double emulsion technique. The in vitro release behavior of BSA from the scaffold under dynamic cyclic loading was studied in comparison with that under a static condition as well as from PELA microspheres. It was observed that the microsphere-incorporated scaffold prolonged BSA release with respect to the microspheres. The cyclic loading accelerated the release of BSA from the scaffold and the cumulative release on day 10 reached 85% of the totally encapsulated BSA. The delivery under a dynamic condition would be an initial study of in vivo localized delivery of growth factors. © 2010 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/139387
ISSN
2015 Impact Factor: 3.42
2015 SCImago Journal Rankings: 1.332
ISI Accession Number ID
Funding AgencyGrant Number
Natural Science Foundation of China10672015
30828008
Funding Information:

Contract grant sponsor: Natural Science Foundation of China via grant nos. 10672015 and 30828008.

References

 

DC FieldValueLanguage
dc.contributor.authorYang, Yen_HK
dc.contributor.authorTang, Gen_HK
dc.contributor.authorZhang, Hen_HK
dc.contributor.authorZhao, Yen_HK
dc.contributor.authorYuan, Xen_HK
dc.contributor.authorFan, Yen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2011-09-23T05:49:04Z-
dc.date.available2011-09-23T05:49:04Z-
dc.date.issued2011en_HK
dc.identifier.citationMaterials Science And Engineering C, 2011, v. 31 n. 2, p. 350-356en_HK
dc.identifier.issn0928-4931en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139387-
dc.description.abstractLocalized delivery of bioactive molecules from porous biodegradable scaffolds is very important in advanced tissue engineering strategies, and it is necessary to study the delivery under dynamic loading which mimics the in vivo biomechanical environments. In this study, bovine serum albumin (BSA), a model of bioactive proteins, was incorporated into porous poly(l-lactide-co-glycolide) (PLGA) scaffolds by seeding BSA-loaded microspheres onto the scaffold pore wall, where the microspheres of poly(ethylene glycol)-b-poly(l-lactide) (PELA) were prepared by double emulsion technique. The in vitro release behavior of BSA from the scaffold under dynamic cyclic loading was studied in comparison with that under a static condition as well as from PELA microspheres. It was observed that the microsphere-incorporated scaffold prolonged BSA release with respect to the microspheres. The cyclic loading accelerated the release of BSA from the scaffold and the cumulative release on day 10 reached 85% of the totally encapsulated BSA. The delivery under a dynamic condition would be an initial study of in vivo localized delivery of growth factors. © 2010 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/msecen_HK
dc.relation.ispartofMaterials Science and Engineering Cen_HK
dc.subjectBSAen_HK
dc.subjectCyclic loadingen_HK
dc.subjectMicrosphereen_HK
dc.subjectReleaseen_HK
dc.subjectScaffolden_HK
dc.titleControlled release of BSA by microsphere-incorporated PLGA scaffolds under cyclic loadingen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.msec.2010.10.006en_HK
dc.identifier.scopuseid_2-s2.0-78650706701en_HK
dc.identifier.hkuros193978en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650706701&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue2en_HK
dc.identifier.spage350en_HK
dc.identifier.epage356en_HK
dc.identifier.isiWOS:000286707900041-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridYang, Y=36669427500en_HK
dc.identifier.scopusauthoridTang, G=23494188700en_HK
dc.identifier.scopusauthoridZhang, H=13305519300en_HK
dc.identifier.scopusauthoridZhao, Y=23494436100en_HK
dc.identifier.scopusauthoridYuan, X=7402202655en_HK
dc.identifier.scopusauthoridFan, Y=23134679300en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK
dc.identifier.citeulike8071602-

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