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Article: Multicompartment polymersome gel for encapsulation

TitleMulticompartment polymersome gel for encapsulation
Authors
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.softmatter.org
Citation
Soft Matter, 2011, v. 7 n. 19, p. 8762-8765 How to Cite?
AbstractWe introduce an approach that combines the concepts of emulsion-templating and dewetting for fabricating polymersomes with a large number of compartments. The resultant polymersome gel behaves as a gel-like solid, but is a true vesicle suspended in an aqueous environment. Due to the thin membranes that separate the compartments, the polymersome gels have a high volume fraction of internal phase for encapsulation of hydrophilic actives; they also provide a large surface area of diblock copolymer membrane for encapsulation of lipophilic actives. Multiple actives can also be encapsulated in the gel without cross-contamination. Our technique represents a simple and versatile bulk approach for fabricating polymersome gels; it does not require the use of any specialized equipment or subsequent polymerization steps to solidify the gel. The resultant polymersome gel is promising as an encapsulating structure as well as a scaffold for tissue engineering. © 2011 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/139376
ISSN
2015 Impact Factor: 3.798
2015 SCImago Journal Rankings: 1.728
ISI Accession Number ID
Funding AgencyGrant Number
NSFDMR-1006546
Harvard MRSECDMR-0820484
University of Hong Kong201101159009
BASF
Funding Information:

This work was supported by the NSF (DMR-1006546), the Harvard MRSEC (DMR-0820484), the Seed Funding Programme for Basic Research from the University of Hong Kong (201101159009) and BASF. We thank Christian Holtze for helpful discussions.

References

 

DC FieldValueLanguage
dc.contributor.authorShum, HCen_HK
dc.contributor.authorWeitz, DAen_HK
dc.date.accessioned2011-09-23T05:48:59Z-
dc.date.available2011-09-23T05:48:59Z-
dc.date.issued2011en_HK
dc.identifier.citationSoft Matter, 2011, v. 7 n. 19, p. 8762-8765en_HK
dc.identifier.issn1744-683Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/139376-
dc.description.abstractWe introduce an approach that combines the concepts of emulsion-templating and dewetting for fabricating polymersomes with a large number of compartments. The resultant polymersome gel behaves as a gel-like solid, but is a true vesicle suspended in an aqueous environment. Due to the thin membranes that separate the compartments, the polymersome gels have a high volume fraction of internal phase for encapsulation of hydrophilic actives; they also provide a large surface area of diblock copolymer membrane for encapsulation of lipophilic actives. Multiple actives can also be encapsulated in the gel without cross-contamination. Our technique represents a simple and versatile bulk approach for fabricating polymersome gels; it does not require the use of any specialized equipment or subsequent polymerization steps to solidify the gel. The resultant polymersome gel is promising as an encapsulating structure as well as a scaffold for tissue engineering. © 2011 The Royal Society of Chemistry.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.softmatter.orgen_HK
dc.relation.ispartofSoft Matteren_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMulticompartment polymersome gel for encapsulationen_HK
dc.typeArticleen_HK
dc.identifier.emailShum, HC:ashum@hku.hken_HK
dc.identifier.authorityShum, HC=rp01439en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1039/c1sm06026ken_HK
dc.identifier.scopuseid_2-s2.0-84855610011en_HK
dc.identifier.hkuros193611en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855610011&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue19en_HK
dc.identifier.spage8762en_HK
dc.identifier.epage8765en_HK
dc.identifier.eissn1744-6848-
dc.identifier.isiWOS:000295085700011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridShum, HC=23976513800en_HK
dc.identifier.scopusauthoridWeitz, DA=7006798731en_HK

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