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Article: Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

TitleEarly development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer
Authors
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/loc
Citation
Lab On A Chip - Miniaturisation For Chemistry And Biology, 2011, v. 11 n. 14, p. 2362-2368 How to Cite?
AbstractEarly development drug formulation is exacerbated by increasingly poor bioavailability of potential candidates. Prevention of attrition due to formulation problems necessitates physicochemical analysis and formulation studies at a very early stage during development, where the availability of a new substance is limited to small quantities, thus impeding extensive experiments. Miniaturization of common formulation processes is a strategy to overcome those limitations. We present a versatile technique for fabricating drug nanoformulations using a microfluidic spray dryer. Nanoparticles are formed by evaporative precipitation of the drug-loaded spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles of 20-60 nm in diameter are prepared with a narrow size distribution. We design the device with a geometry that allows the injection of two separate solvent streams, thus enabling co-spray drying of two substances for the production of drug co-precipitates with tailor-made composition for optimization of therapeutic efficiency. © 2011 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/139375
ISSN
2015 Impact Factor: 5.586
2015 SCImago Journal Rankings: 2.373
ISI Accession Number ID
Funding AgencyGrant Number
BASF
NSFDMR-0602684
ECS-0335765
Harvard MRSECDMR-0820484
Massachusetts Life Sciences Center
Chemical Industry (Germany)
German Academic Exchange Service
Funding Information:

We thank Christian Holtze and Jim Wilking for helpful discussions and COMSOL AB for technical support. This work was supported by BASF, the NSF (DMR-0602684), the Harvard MRSEC (DMR-0820484), and the Massachusetts Life Sciences Center. Experiments were performed in part at the Center for Nanoscale Systems (CNS), which is supported by the NSF (ECS-0335765). JT received funding from the Fund of the Chemical Industry (Germany) and MW was funded by the German Academic Exchange Service.

References

 

DC FieldValueLanguage
dc.contributor.authorThiele, Jen_HK
dc.contributor.authorWindbergs, Men_HK
dc.contributor.authorAbate, ARen_HK
dc.contributor.authorTrebbin, Men_HK
dc.contributor.authorShum, HCen_HK
dc.contributor.authorFörster, Sen_HK
dc.contributor.authorWeitz, DAen_HK
dc.date.accessioned2011-09-23T05:48:59Z-
dc.date.available2011-09-23T05:48:59Z-
dc.date.issued2011en_HK
dc.identifier.citationLab On A Chip - Miniaturisation For Chemistry And Biology, 2011, v. 11 n. 14, p. 2362-2368en_HK
dc.identifier.issn1473-0197en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139375-
dc.description.abstractEarly development drug formulation is exacerbated by increasingly poor bioavailability of potential candidates. Prevention of attrition due to formulation problems necessitates physicochemical analysis and formulation studies at a very early stage during development, where the availability of a new substance is limited to small quantities, thus impeding extensive experiments. Miniaturization of common formulation processes is a strategy to overcome those limitations. We present a versatile technique for fabricating drug nanoformulations using a microfluidic spray dryer. Nanoparticles are formed by evaporative precipitation of the drug-loaded spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles of 20-60 nm in diameter are prepared with a narrow size distribution. We design the device with a geometry that allows the injection of two separate solvent streams, thus enabling co-spray drying of two substances for the production of drug co-precipitates with tailor-made composition for optimization of therapeutic efficiency. © 2011 The Royal Society of Chemistry.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/locen_HK
dc.relation.ispartofLab on a Chip - Miniaturisation for Chemistry and Biologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshDanazol - chemistryen_HK
dc.subject.meshDrug Compounding - instrumentation - methodsen_HK
dc.subject.meshMicrofluidic Analytical Techniques - instrumentationen_HK
dc.subject.meshMiniaturizationen_HK
dc.subject.meshNanoparticles - chemistryen_HK
dc.subject.meshParticle Sizeen_HK
dc.subject.meshPressureen_HK
dc.subject.meshSolvents - chemistryen_HK
dc.subject.meshTemperatureen_HK
dc.titleEarly development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryeren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1473-0197&volume=11&issue=14&spage=2362&epage=2368&date=2011&atitle=Early+development+drug+formulation+on+a+chip:+Fabrication+of+nanoparticles+using+a+microfluidic+spray+dryeren_US
dc.identifier.emailShum, HC:ashum@hku.hken_HK
dc.identifier.authorityShum, HC=rp01439en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1039/c1lc20298gen_HK
dc.identifier.pmid21617823-
dc.identifier.scopuseid_2-s2.0-80051739175en_HK
dc.identifier.hkuros193602en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051739175&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue14en_HK
dc.identifier.spage2362en_HK
dc.identifier.epage2368en_HK
dc.identifier.isiWOS:000292168500009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridThiele, J=23989569300en_HK
dc.identifier.scopusauthoridWindbergs, M=24492417900en_HK
dc.identifier.scopusauthoridAbate, AR=9841399300en_HK
dc.identifier.scopusauthoridTrebbin, M=45461457100en_HK
dc.identifier.scopusauthoridShum, HC=23976513800en_HK
dc.identifier.scopusauthoridFörster, S=7101707557en_HK
dc.identifier.scopusauthoridWeitz, DA=7006798731en_HK

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