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Article: Dewetting-induced membrane formation by adhesion of amphiphile-laden interfaces

TitleDewetting-induced membrane formation by adhesion of amphiphile-laden interfaces
Authors
Issue Date2011
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2011, v. 133 n. 12, p. 4420-4426 How to Cite?
AbstractWe introduce an approach for forming bilayer polymer membranes by adhesion of amphiphile-laden interfaces. This adhesion is induced by a reduction of solvent quality for the amphiphilic diblock copolymers through selective evaporation of good solvent in the solvent mixture. By combining this membrane formation mechanism with a double-emulsion-templated approach for vesicle formation, we fabricate monodisperse polymersomes that exhibit excellent membrane uniformity, and structural stability, using a method that has high encapsulation efficiency. Moreover, we also show that the technique is versatile and can be applied to different block copolymers. The ability to direct the assembly of amphiphiles into a membrane creates new opportunities to engineer the structures of vesicles on the level of the individual bilayer leaflets. © 2011 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/139371
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
ISI Accession Number ID
Funding AgencyGrant Number
NSFDMR-10006546
Harvard MRSECDMR-0820484
BASF Ludwigshafen in Germany
National Institutes of HealthHL007680
Funding Information:

This work was supported by the NSF (No. DMR-10006546) and the Harvard MRSEC (No. DMR-0820484). H.C.S. and D.A.W. were supported in part by BASF Ludwigshafen in Germany. A.E. was supported by a National Institutes of Health Grant (No. HL007680). We thank Tom Kodger for help with DLS measurements, Debra Auguste for use of the freeze-dryer, as well as David Lange (Harvard CNS), Woods Hole Marine Biological Laboratory and Leica Microsystems, Inc. for the use and help with the cryo-SEM imaging.

References

 

DC FieldValueLanguage
dc.contributor.authorShum, HCen_HK
dc.contributor.authorSantanachCarreras, Een_HK
dc.contributor.authorKim, JWen_HK
dc.contributor.authorEhrlicher, Aen_HK
dc.contributor.authorBibette, Jen_HK
dc.contributor.authorWeitz, DAen_HK
dc.date.accessioned2011-09-23T05:48:56Z-
dc.date.available2011-09-23T05:48:56Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of The American Chemical Society, 2011, v. 133 n. 12, p. 4420-4426en_HK
dc.identifier.issn0002-7863en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139371-
dc.description.abstractWe introduce an approach for forming bilayer polymer membranes by adhesion of amphiphile-laden interfaces. This adhesion is induced by a reduction of solvent quality for the amphiphilic diblock copolymers through selective evaporation of good solvent in the solvent mixture. By combining this membrane formation mechanism with a double-emulsion-templated approach for vesicle formation, we fabricate monodisperse polymersomes that exhibit excellent membrane uniformity, and structural stability, using a method that has high encapsulation efficiency. Moreover, we also show that the technique is versatile and can be applied to different block copolymers. The ability to direct the assembly of amphiphiles into a membrane creates new opportunities to engineer the structures of vesicles on the level of the individual bilayer leaflets. © 2011 American Chemical Society.en_HK
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_HK
dc.relation.ispartofJournal of the American Chemical Societyen_HK
dc.subject.meshMembranes, Artificial-
dc.subject.meshParticle Size-
dc.subject.meshPolymers - chemistry-
dc.subject.meshSurface Properties-
dc.titleDewetting-induced membrane formation by adhesion of amphiphile-laden interfacesen_HK
dc.typeArticleen_HK
dc.identifier.emailShum, HC:ashum@hku.hken_HK
dc.identifier.authorityShum, HC=rp01439en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja108673hen_HK
dc.identifier.pmid21381735-
dc.identifier.scopuseid_2-s2.0-79953062762en_HK
dc.identifier.hkuros193598en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79953062762&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133en_HK
dc.identifier.issue12en_HK
dc.identifier.spage4420en_HK
dc.identifier.epage4426en_HK
dc.identifier.eissn1520-5126-
dc.identifier.isiWOS:000291715300048-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShum, HC=23976513800en_HK
dc.identifier.scopusauthoridSantanachCarreras, E=36654578200en_HK
dc.identifier.scopusauthoridKim, JW=36012700600en_HK
dc.identifier.scopusauthoridEhrlicher, A=36437057300en_HK
dc.identifier.scopusauthoridBibette, J=7003384516en_HK
dc.identifier.scopusauthoridWeitz, DA=7006798731en_HK

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