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Article: Peri-tumoural magnetic resonance spectroscopy to differentiate solitary primary intra-axial high-grade glioma and brain metastasis: A pilot study

TitlePeri-tumoural magnetic resonance spectroscopy to differentiate solitary primary intra-axial high-grade glioma and brain metastasis: A pilot study
Authors
KeywordsBrain neoplasms
Choline
Glioma
Image enhancement
Protons
Issue Date2010
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkcr.org/
Citation
Journal of the Hong Kong College of Radiologists, 2010, v. 13 n. 4, p. 195-198 How to Cite?
AbstractObjective: To determine whether the peri-tumoural choline/N-acetyl- aspartate ratio can be used to differentiate solitary primary intra-axial brain tumour and metatasis. Methods: In this retrospective study, 18 treatment-naïve adults presenting with a solitary intra-axial mass underwent conventional contrast-enhanced and proton spectroscopic magnetic resonance imaging. The images were interpreted retrospectively by an experienced neuroradiologist and a radiology fellow with 6 years' experience. The radiologists were blinded to the clinicopathological and demographic data. The choline/N-acetyl-aspartate ratio was measured over the area of peri-tumoural oedema, which was defined by T2 hyperintensity and non-enhancing areas immediately adjacent to the enhancing portion of the tumour. A peri-tumoural choline/N-acetyl-aspartate ratio of >1 was classified as positive, meaning primary brain tumour. Statistical analysis was performed using a 2 x 2 contingency table. The interclass correlation coefficient (alpha) was calculated as the index of concordance exceeding chance for inter-rater reliability. Results: Of 18 patients, four were excluded from the study owing to absence of peri-tumoural cerebral oedema. Of the remaining 14 patients, nine had a solitary intra-axial high-grade gliomas confirmed pathologically, of whom eight had a peri-tumoural choline/N-acetyl-aspartate ratio of >1. The remaining five patients were classified as having a solitary brain metastasis with no known primary. A choline/N-acetyl-aspartate ratio of >1 in peritumoural region can be used as a parameter predicting a primary brain tumour; respective values for sensitivity, specificity, positive and negative predictive values were 90%, 100%, 100% and 83%, respectively. Conclusion: The peri-tumoural choline/N-acetyl-aspartate ratio of >1 can be used as a parameter to differentiate the intra-axial primary brain tumour from metastasis. © 2010 Hong Kong College of Radiologists.
Persistent Identifierhttp://hdl.handle.net/10722/139136
ISSN

 

DC FieldValueLanguage
dc.contributor.authorWong, CSen_US
dc.contributor.authorChu, TYCen_US
dc.contributor.authorMa, JKFen_US
dc.date.accessioned2011-09-23T05:45:42Z-
dc.date.available2011-09-23T05:45:42Z-
dc.date.issued2010en_US
dc.identifier.citationJournal of the Hong Kong College of Radiologists, 2010, v. 13 n. 4, p. 195-198en_US
dc.identifier.issn1029-5097-
dc.identifier.urihttp://hdl.handle.net/10722/139136-
dc.description.abstractObjective: To determine whether the peri-tumoural choline/N-acetyl- aspartate ratio can be used to differentiate solitary primary intra-axial brain tumour and metatasis. Methods: In this retrospective study, 18 treatment-naïve adults presenting with a solitary intra-axial mass underwent conventional contrast-enhanced and proton spectroscopic magnetic resonance imaging. The images were interpreted retrospectively by an experienced neuroradiologist and a radiology fellow with 6 years' experience. The radiologists were blinded to the clinicopathological and demographic data. The choline/N-acetyl-aspartate ratio was measured over the area of peri-tumoural oedema, which was defined by T2 hyperintensity and non-enhancing areas immediately adjacent to the enhancing portion of the tumour. A peri-tumoural choline/N-acetyl-aspartate ratio of >1 was classified as positive, meaning primary brain tumour. Statistical analysis was performed using a 2 x 2 contingency table. The interclass correlation coefficient (alpha) was calculated as the index of concordance exceeding chance for inter-rater reliability. Results: Of 18 patients, four were excluded from the study owing to absence of peri-tumoural cerebral oedema. Of the remaining 14 patients, nine had a solitary intra-axial high-grade gliomas confirmed pathologically, of whom eight had a peri-tumoural choline/N-acetyl-aspartate ratio of >1. The remaining five patients were classified as having a solitary brain metastasis with no known primary. A choline/N-acetyl-aspartate ratio of >1 in peritumoural region can be used as a parameter predicting a primary brain tumour; respective values for sensitivity, specificity, positive and negative predictive values were 90%, 100%, 100% and 83%, respectively. Conclusion: The peri-tumoural choline/N-acetyl-aspartate ratio of >1 can be used as a parameter to differentiate the intra-axial primary brain tumour from metastasis. © 2010 Hong Kong College of Radiologists.-
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkcr.org/-
dc.relation.ispartofJournal of the Hong Kong College of Radiologistsen_US
dc.subjectBrain neoplasms-
dc.subjectCholine-
dc.subjectGlioma-
dc.subjectImage enhancement-
dc.subjectProtons-
dc.titlePeri-tumoural magnetic resonance spectroscopy to differentiate solitary primary intra-axial high-grade glioma and brain metastasis: A pilot studyen_US
dc.typeArticleen_US
dc.identifier.emailWong, CS: drcswong@hku.hken_US
dc.identifier.authorityWong, CS=rp01391en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-79955075535-
dc.identifier.hkuros192260en_US
dc.identifier.volume13-
dc.identifier.issue4-
dc.identifier.spage195-
dc.identifier.epage198-
dc.publisher.placeHong Kong-

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