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Article: Prognostic impact of standardized uptake value of F-18 FDG PET/CT in nasopharyngeal carcinoma
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TitlePrognostic impact of standardized uptake value of F-18 FDG PET/CT in nasopharyngeal carcinoma
 
AuthorsChan, WKS1
Kwong, DLW1
Yeung, DWC1
Huang, B1
Khong, PL1
 
Keywordsnasopharyngeal carcinoma
PET/CT
prognosis
survival
SUV
 
Issue Date2011
 
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmed.com/
 
CitationClinical Nuclear Medicine, 2011, v. 36 n. 11, p. 1007-1011 [How to Cite?]
DOI: http://dx.doi.org/10.1097/RLU.0b013e31821a29a4
 
AbstractPurpose: We evaluated the use of metabolic parameters of F-18 fluorodeoxyglucose positron emission tomography (FDG PET) for the assessment of the primary tumor and nodal metastasis in predicting survival in nasopharyngeal carcinoma (NPC) patients. Materials and Methods: The F-18 FDG PET/CT (computed tomography) scans of 46 consecutive newly diagnosed NPC patients were retrospectively reviewed. Maximal standardized uptake value (SUV max) corrected for lean body mass of primary tumor (pSUV max) and highest SUV max of cervical lymph nodes (nSUV max) were recorded. The association of FDG uptake and 2-year disease-free survival (DFS) was examined. Results: Significantly better DFS was found in patients with pSUV max <7.5 and nSUV max <6.5 (P = 0.042 and P = 0.019, respectively). In multivariate analysis, both pSUV max and nSUV max were significant independent predictors of DFS. Conclusions: The SUV max of the primary tumor and nodal metastasis are useful parameters for predicting DFS in NPC patients. Copyright © 2011 by Lippincott Williams & Wilkins.
 
ISSN0363-9762
2012 Impact Factor: 2.955
2012 SCImago Journal Rankings: 0.391
 
DOIhttp://dx.doi.org/10.1097/RLU.0b013e31821a29a4
 
ISI Accession Number IDWOS:000295871900015
Funding AgencyGrant Number
The Center for Nasopharyngeal Carcinoma Research, Hong Kong SAR, ChinaAoE/M-06/08
Funding Information:

Conflicts of interest and sources of funding: supported by The Center for Nasopharyngeal Carcinoma Research, Hong Kong SAR, China, AoE grant AoE/M-06/08.

 
ReferencesReferences in Scopus
 
GrantsCentre for Nasopharyngeal Carcinoma Research
 
DC FieldValue
dc.contributor.authorChan, WKS
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorYeung, DWC
 
dc.contributor.authorHuang, B
 
dc.contributor.authorKhong, PL
 
dc.date.accessioned2011-09-23T05:45:38Z
 
dc.date.available2011-09-23T05:45:38Z
 
dc.date.issued2011
 
dc.description.abstractPurpose: We evaluated the use of metabolic parameters of F-18 fluorodeoxyglucose positron emission tomography (FDG PET) for the assessment of the primary tumor and nodal metastasis in predicting survival in nasopharyngeal carcinoma (NPC) patients. Materials and Methods: The F-18 FDG PET/CT (computed tomography) scans of 46 consecutive newly diagnosed NPC patients were retrospectively reviewed. Maximal standardized uptake value (SUV max) corrected for lean body mass of primary tumor (pSUV max) and highest SUV max of cervical lymph nodes (nSUV max) were recorded. The association of FDG uptake and 2-year disease-free survival (DFS) was examined. Results: Significantly better DFS was found in patients with pSUV max <7.5 and nSUV max <6.5 (P = 0.042 and P = 0.019, respectively). In multivariate analysis, both pSUV max and nSUV max were significant independent predictors of DFS. Conclusions: The SUV max of the primary tumor and nodal metastasis are useful parameters for predicting DFS in NPC patients. Copyright © 2011 by Lippincott Williams & Wilkins.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationClinical Nuclear Medicine, 2011, v. 36 n. 11, p. 1007-1011 [How to Cite?]
DOI: http://dx.doi.org/10.1097/RLU.0b013e31821a29a4
 
dc.identifier.doihttp://dx.doi.org/10.1097/RLU.0b013e31821a29a4
 
dc.identifier.epage1011
 
dc.identifier.hkuros192104
 
dc.identifier.isiWOS:000295871900015
Funding AgencyGrant Number
The Center for Nasopharyngeal Carcinoma Research, Hong Kong SAR, ChinaAoE/M-06/08
Funding Information:

Conflicts of interest and sources of funding: supported by The Center for Nasopharyngeal Carcinoma Research, Hong Kong SAR, China, AoE grant AoE/M-06/08.

 
dc.identifier.issn0363-9762
2012 Impact Factor: 2.955
2012 SCImago Journal Rankings: 0.391
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmid21975389
 
dc.identifier.scopuseid_2-s2.0-80053965385
 
dc.identifier.spage1007
 
dc.identifier.urihttp://hdl.handle.net/10722/139131
 
dc.identifier.volume36
 
dc.languageeng
 
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmed.com/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical Nuclear Medicine
 
dc.relation.projectCentre for Nasopharyngeal Carcinoma Research
 
dc.relation.referencesReferences in Scopus
 
dc.subjectnasopharyngeal carcinoma
 
dc.subjectPET/CT
 
dc.subjectprognosis
 
dc.subjectsurvival
 
dc.subjectSUV
 
dc.titlePrognostic impact of standardized uptake value of F-18 FDG PET/CT in nasopharyngeal carcinoma
 
dc.typeArticle
 
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<description.abstract>Purpose: We evaluated the use of metabolic parameters of F-18 fluorodeoxyglucose positron emission tomography (FDG PET) for the assessment of the primary tumor and nodal metastasis in predicting survival in nasopharyngeal carcinoma (NPC) patients. Materials and Methods: The F-18 FDG PET/CT (computed tomography) scans of 46 consecutive newly diagnosed NPC patients were retrospectively reviewed. Maximal standardized uptake value (SUV max) corrected for lean body mass of primary tumor (pSUV max) and highest SUV max of cervical lymph nodes (nSUV max) were recorded. The association of FDG uptake and 2-year disease-free survival (DFS) was examined. Results: Significantly better DFS was found in patients with pSUV max &lt;7.5 and nSUV max &lt;6.5 (P = 0.042 and P = 0.019, respectively). In multivariate analysis, both pSUV max and nSUV max were significant independent predictors of DFS. Conclusions: The SUV max of the primary tumor and nodal metastasis are useful parameters for predicting DFS in NPC patients. Copyright &#169; 2011 by Lippincott Williams &amp; Wilkins.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong