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Article: Relationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythematosus

TitleRelationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythematosus
Authors
KeywordsRheumatoid arthritis
Systemic calcified atherosclerosis
Systemic lupus erythematosus
Valvular calcification
Issue Date2011
PublisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
Citation
Journal Of Rheumatology, 2011, v. 38 n. 4, p. 621-627 How to Cite?
AbstractObjective. Cardiac valvular calcification has been linked with systemic atherosclerosis in the general population. The prevalence and relationship with arterial calcification in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is unknown. We investigated the prevalence of valvular calcification in patients with RA and SLE and its relationship with arterial atherosclerotic calcification. Methods.We compared aortic valve calcification (AVC), mitral valve calcification (MVC), and systemic vascular bed calcification using multidetector computed tomography in 110 patients (mean age 46.5 ± 9.4 yrs, 97 women) with RA (n = 58) or SLE (n = 52) and 60 age and sex-matched healthy controls. Results. Patients with RA and SLE, combined, had significantly higher prevalence of AVC (21.8% vs 3.3% in controls; p < 0.01), MVC (19.1% vs 0% in controls; p < 0.01), and arterial calcification in different vascular beds (all p < 0.05). AVC was not associated with any specific clinical characteristics, but MVC was associated with older age, hypertension, C-reactive protein level, and duration of disease. The presence of MVC was independently associated with coronary calcification and calcification in any vascular bed upon adjustment with clinical measures. Conclusion. Our study demonstrated that cardiac valvular calcification is more prevalent in patients with RA and SLE compared with healthy controls. The presence of MVC, but not AVC, independently predicted the occurrence of premature atherosclerosis with arterial calcification in patients with RA and SLE. The Journal of Rheumatology Copyright © 2011. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/139126
ISSN
2015 Impact Factor: 3.236
2015 SCImago Journal Rankings: 1.225
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorMok, MYen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2011-09-23T05:45:33Z-
dc.date.available2011-09-23T05:45:33Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Rheumatology, 2011, v. 38 n. 4, p. 621-627en_HK
dc.identifier.issn0315-162Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/139126-
dc.description.abstractObjective. Cardiac valvular calcification has been linked with systemic atherosclerosis in the general population. The prevalence and relationship with arterial calcification in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is unknown. We investigated the prevalence of valvular calcification in patients with RA and SLE and its relationship with arterial atherosclerotic calcification. Methods.We compared aortic valve calcification (AVC), mitral valve calcification (MVC), and systemic vascular bed calcification using multidetector computed tomography in 110 patients (mean age 46.5 ± 9.4 yrs, 97 women) with RA (n = 58) or SLE (n = 52) and 60 age and sex-matched healthy controls. Results. Patients with RA and SLE, combined, had significantly higher prevalence of AVC (21.8% vs 3.3% in controls; p < 0.01), MVC (19.1% vs 0% in controls; p < 0.01), and arterial calcification in different vascular beds (all p < 0.05). AVC was not associated with any specific clinical characteristics, but MVC was associated with older age, hypertension, C-reactive protein level, and duration of disease. The presence of MVC was independently associated with coronary calcification and calcification in any vascular bed upon adjustment with clinical measures. Conclusion. Our study demonstrated that cardiac valvular calcification is more prevalent in patients with RA and SLE compared with healthy controls. The presence of MVC, but not AVC, independently predicted the occurrence of premature atherosclerosis with arterial calcification in patients with RA and SLE. The Journal of Rheumatology Copyright © 2011. All rights reserved.en_HK
dc.languageengen_US
dc.publisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.comen_HK
dc.relation.ispartofJournal of Rheumatologyen_HK
dc.subjectRheumatoid arthritisen_HK
dc.subjectSystemic calcified atherosclerosisen_HK
dc.subjectSystemic lupus erythematosusen_HK
dc.subjectValvular calcificationen_HK
dc.subject.meshArteries - pathology-
dc.subject.meshArthritis, Rheumatoid - complications - pathology - physiopathology-
dc.subject.meshCalcinosis - epidemiology - etiology - pathology-
dc.subject.meshHeart Valve Diseases - epidemiology - etiology - pathology-
dc.subject.meshLupus Erythematosus, Systemic - complications - pathology - physiopathology-
dc.titleRelationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3899/jrheum.100844en_HK
dc.identifier.pmid21285175-
dc.identifier.scopuseid_2-s2.0-79953299175en_HK
dc.identifier.hkuros192044en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79953299175&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue4en_HK
dc.identifier.spage621en_HK
dc.identifier.epage627en_HK
dc.identifier.eissn1499-2752-
dc.identifier.isiWOS:000289333800008-
dc.publisher.placeCanadaen_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridWang, S=24598284300en_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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