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Article: Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro

TitleBlockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro
Authors
Issue Date2008
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2008, v. 263 n. 2, p. 302-311 How to Cite?
AbstractGastrin and cyclooxygenase-2 (COX-2) play important roles in the carcinogenesis and progression of gastric cancer. However, it remains unknown whether the combination of cholecystokinin-2 (CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer. Here, we demonstrated that the combination of AG-041R (a CCK-2 receptor antagonist) plus NS-398 (a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells. These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.
Persistent Identifierhttp://hdl.handle.net/10722/138983
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSun, WHen_US
dc.contributor.authorZhu, Fen_US
dc.contributor.authorChen, GSen_US
dc.contributor.authorSun, Hen_US
dc.contributor.authorLuo, Cen_US
dc.contributor.authorZhao, QSen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorShao, Yen_US
dc.contributor.authorSun, Jen_US
dc.contributor.authorZhou, SMen_US
dc.contributor.authorDing, GXen_US
dc.contributor.authorCheng, YLen_US
dc.date.accessioned2011-09-23T05:43:38Z-
dc.date.available2011-09-23T05:43:38Z-
dc.date.issued2008en_US
dc.identifier.citationCancer Letters, 2008, v. 263 n. 2, p. 302-311en_US
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10722/138983-
dc.description.abstractGastrin and cyclooxygenase-2 (COX-2) play important roles in the carcinogenesis and progression of gastric cancer. However, it remains unknown whether the combination of cholecystokinin-2 (CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer. Here, we demonstrated that the combination of AG-041R (a CCK-2 receptor antagonist) plus NS-398 (a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells. These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.-
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subject.meshApoptosis - drug effects-
dc.subject.meshCell Line, Tumor-
dc.subject.meshCyclooxygenase 2 Inhibitors - pharmacology-
dc.subject.meshReceptor, Cholecystokinin B - antagonists and inhibitors-
dc.subject.meshStomach Neoplasms - pathology-
dc.titleBlockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitroen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=263&issue=2&spage=302&epage=311&date=2008&atitle=Blockade+of+cholecystokinin-2+receptor+and+cyclooxygenase-2+synergistically+induces+cell+apoptosis,+and+inhibits+the+proliferation+of+human+gastric+cancer+cells+in+vitro-
dc.identifier.emailSun, WH: weihaosun@hotmail.com-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2008.01.012-
dc.identifier.pmid18258354-
dc.identifier.scopuseid_2-s2.0-41649085978-
dc.identifier.hkuros194489en_US
dc.identifier.volume263en_US
dc.identifier.issue2-
dc.identifier.spage302en_US
dc.identifier.epage311en_US
dc.identifier.isiWOS:000255810500017-

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