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Article: Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats

TitleHippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats
Authors
KeywordsAnimal behavior
Brain development
Dendritic cell
Nerve cell plasticity
Spatial learning
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 9 How to Cite?
AbstractExercise promotes hippocampal neurogenesis and dendritic plasticity while stress shows the opposite effects, suggesting a possible mechanism for exercise to counteract stress. Changes in hippocampal neurogenesis and dendritic modification occur simultaneously in rats with stress or exercise; however, it is unclear whether neurogenesis or dendritic remodeling has a greater impact on mediating the effect of exercise on stress since they have been separately examined. Here we examined hippocampal cell proliferation in runners treated with different doses (low: 30 mg/kg; moderate: 40 mg/kg; high: 50 mg/kg) of corticosterone (CORT) for 14 days. Water maze task and forced swim tests were applied to assess hippocampal-dependent learning and depression-like behaviour respectively the day after the treatment. Repeated CORT treatment resulted in a graded increase in depression-like behaviour and impaired spatial learning that is associated with decreased hippocampal cell proliferation and BDNF levels. Running reversed these effects in rats treated with low or moderate, but not high doses of CORT. Using 40 mg/kg CORT-treated rats, we further studied the role of neurogenesis and dendritic remodeling in mediating the effects of exercise on stress. Co-labelling with BrdU (thymidine analog)/doublecortin (immature neuronal marker) showed that running increased neuronal differentiation in vehicle- and CORT-treated rats. Running also increased dendritic length and spine density in CA3 pyramidal neurons in 40 mg/kg CORT-treated rats. Ablation of neurogenesis with Ara-c infusion diminished the effect of running on restoring spatial learning and decreasing depression-like behaviour in 40 mg/kg CORT-treated animals in spite of dendritic and spine enhancement. but not normal runners with enhanced dendritic length. The results indicate that both restored hippocampal neurogenesis and dendritic remodelling within the hippocampus are essential for running to counteract stress. © 2011 Yau et al.
Persistent Identifierhttp://hdl.handle.net/10722/138949
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research Limited
National Natural Science Foundation of China
University Grants Committee of the Hong Kong
University of Hong Kong
Fundamental Research Fund for the Central Universities21609101
Funding Information:

This study was supported by funding from the Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited), the National Natural Science Foundation of China, the Areas of Excellence (AoE) Scheme established under the University Grants Committee of the Hong Kong and AoE Matching Fund from the University of Hong Kong and the Fundamental Research Fund for the Central Universities (21609101, K-FS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorYau, SYen_HK
dc.contributor.authorLau, BWMen_HK
dc.contributor.authorTong, JBen_HK
dc.contributor.authorWong, Ren_HK
dc.contributor.authorChing, YPen_HK
dc.contributor.authorQiu, Gen_HK
dc.contributor.authorTang, SWen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2011-09-23T05:42:49Z-
dc.date.available2011-09-23T05:42:49Z-
dc.date.issued2011en_HK
dc.identifier.citationPlos One, 2011, v. 6 n. 9en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138949-
dc.description.abstractExercise promotes hippocampal neurogenesis and dendritic plasticity while stress shows the opposite effects, suggesting a possible mechanism for exercise to counteract stress. Changes in hippocampal neurogenesis and dendritic modification occur simultaneously in rats with stress or exercise; however, it is unclear whether neurogenesis or dendritic remodeling has a greater impact on mediating the effect of exercise on stress since they have been separately examined. Here we examined hippocampal cell proliferation in runners treated with different doses (low: 30 mg/kg; moderate: 40 mg/kg; high: 50 mg/kg) of corticosterone (CORT) for 14 days. Water maze task and forced swim tests were applied to assess hippocampal-dependent learning and depression-like behaviour respectively the day after the treatment. Repeated CORT treatment resulted in a graded increase in depression-like behaviour and impaired spatial learning that is associated with decreased hippocampal cell proliferation and BDNF levels. Running reversed these effects in rats treated with low or moderate, but not high doses of CORT. Using 40 mg/kg CORT-treated rats, we further studied the role of neurogenesis and dendritic remodeling in mediating the effects of exercise on stress. Co-labelling with BrdU (thymidine analog)/doublecortin (immature neuronal marker) showed that running increased neuronal differentiation in vehicle- and CORT-treated rats. Running also increased dendritic length and spine density in CA3 pyramidal neurons in 40 mg/kg CORT-treated rats. Ablation of neurogenesis with Ara-c infusion diminished the effect of running on restoring spatial learning and decreasing depression-like behaviour in 40 mg/kg CORT-treated animals in spite of dendritic and spine enhancement. but not normal runners with enhanced dendritic length. The results indicate that both restored hippocampal neurogenesis and dendritic remodelling within the hippocampus are essential for running to counteract stress. © 2011 Yau et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.subjectAnimal behavior-
dc.subjectBrain development-
dc.subjectDendritic cell-
dc.subjectNerve cell plasticity-
dc.subjectSpatial learning-
dc.titleHippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1932-6203&volume=6&issue=9&spage=e24263&epage=&date=2011&atitle=Hippocampal+neurogenesis+and+dendritic+plasticity+support+running-improved+spatial+learning+and+depression-like+behaviour+in+stressed+rats-
dc.identifier.emailChing, YP:ypching@hku.hken_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityChing, YP=rp00469en_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0024263en_HK
dc.identifier.pmid21935393-
dc.identifier.pmcidPMC3174166-
dc.identifier.scopuseid_2-s2.0-80052855237en_HK
dc.identifier.hkuros196592en_US
dc.identifier.hkuros197906-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052855237&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue9en_HK
dc.identifier.isiWOS:000295041700021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYau, SY=24330296200en_HK
dc.identifier.scopusauthoridLau, BWM=21934562200en_HK
dc.identifier.scopusauthoridTong, JB=14023686000en_HK
dc.identifier.scopusauthoridWong, R=52464699200en_HK
dc.identifier.scopusauthoridChing, YP=7005431277en_HK
dc.identifier.scopusauthoridQiu, G=36790708100en_HK
dc.identifier.scopusauthoridTang, SW=23968420300en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.citeulike9782188-

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