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Article: Low-dose desmopressin improves hypothermia-induced impairment of primary haemostasis in healthy volunteers

TitleLow-dose desmopressin improves hypothermia-induced impairment of primary haemostasis in healthy volunteers
Authors
Issue Date2011
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409
Citation
Anaesthesia, 2011, v. 66 n. 11, p. 999-1005 How to Cite?
AbstractMild hypothermia (34-35 °C) increases peri-operative blood loss. We have previously demonstrated the beneficial effect of in vitro desmopressin on impairment of primary haemostasis associated with hypothermia. This study evaluated subcutaneous desmopressin in 52 healthy volunteers, randomly assigned to receive either normal saline or desmopressin 1.5, 5 or 15 μg (with 13 in each group). Blood samples were collected before and 2 h after drug administration and incubated at 32 and 37 °C. Platelet function analyser PFA-100® closure times were measured. Hypothermia at 32 °C prolonged mean (95% CI) closure times (for adenosine diphosphate/collagen by 11.3% (7.5-15.2%) and for adrenaline/collagen by 16.2% (11.3-21.2%); these changes were reversed by desmopressin. A very small dose was found to be effective (1.5 μg); this dose did not significantly change closure times at 37 °C, but fully prevented its prolongation at 32 °C. Subcutaneous desmopressin prevents the development of hypothermia-induced impairment of primary haemostasis. © 2011 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/138939
ISSN
2015 Impact Factor: 3.794
2015 SCImago Journal Rankings: 1.404
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong CRCG10400611/26981/20100/323/01
Funding Information:

This study is supported in part by a University of Hong Kong CRCG Small Project Funding (Acc Code 10400611/26981/20100/323/01) and in part by departmental funds. The Department of Anaesthesiology of the University of Hong Kong has previously received donations from the manufacturer of desmopressin (Octostim (R); Ferring, Saint-Prex, Switzerland) in support of general research activities in the department. None of the authors has received any sponsorship or other financial support from the manufacturers or distributors of the PFA-100 (R).

References

 

DC FieldValueLanguage
dc.contributor.authorNg, KFJen_HK
dc.contributor.authorCheung, CWen_HK
dc.contributor.authorLee, Yen_HK
dc.contributor.authorLeung, SWSen_HK
dc.date.accessioned2011-09-23T05:42:21Z-
dc.date.available2011-09-23T05:42:21Z-
dc.date.issued2011en_HK
dc.identifier.citationAnaesthesia, 2011, v. 66 n. 11, p. 999-1005en_HK
dc.identifier.issn0003-2409en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138939-
dc.description.abstractMild hypothermia (34-35 °C) increases peri-operative blood loss. We have previously demonstrated the beneficial effect of in vitro desmopressin on impairment of primary haemostasis associated with hypothermia. This study evaluated subcutaneous desmopressin in 52 healthy volunteers, randomly assigned to receive either normal saline or desmopressin 1.5, 5 or 15 μg (with 13 in each group). Blood samples were collected before and 2 h after drug administration and incubated at 32 and 37 °C. Platelet function analyser PFA-100® closure times were measured. Hypothermia at 32 °C prolonged mean (95% CI) closure times (for adenosine diphosphate/collagen by 11.3% (7.5-15.2%) and for adrenaline/collagen by 16.2% (11.3-21.2%); these changes were reversed by desmopressin. A very small dose was found to be effective (1.5 μg); this dose did not significantly change closure times at 37 °C, but fully prevented its prolongation at 32 °C. Subcutaneous desmopressin prevents the development of hypothermia-induced impairment of primary haemostasis. © 2011 The Authors.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409en_HK
dc.relation.ispartofAnaesthesiaen_HK
dc.subject.meshAdult-
dc.subject.meshDeamino Arginine Vasopressin - pharmacology-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshHemostasis - drug effects-
dc.subject.meshHypothermia - blood-
dc.titleLow-dose desmopressin improves hypothermia-induced impairment of primary haemostasis in healthy volunteersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0263-1512&volume=&spage=&epage=&date=2011&atitle=Low+dose+desmopressin+improves+hypothermia+induced+impairmnt+of+primary+haemostasis+in+healthy+volunteersen_US
dc.identifier.emailNg, KFJ: jkfng@hkucc.hku.hken_HK
dc.identifier.emailCheung, CW: cheucw@hku.hken_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.authorityNg, KFJ=rp00544en_HK
dc.identifier.authorityCheung, CW=rp00244en_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1365-2044.2011.06821.xen_HK
dc.identifier.pmid21883124-
dc.identifier.scopuseid_2-s2.0-80054797111en_HK
dc.identifier.hkuros193542en_US
dc.identifier.hkuros200128-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054797111&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume66en_HK
dc.identifier.issue11en_HK
dc.identifier.spage999en_HK
dc.identifier.epage1005en_HK
dc.identifier.isiWOS:000296063300008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNg, KFJ=13608809400en_HK
dc.identifier.scopusauthoridCheung, CW=24754835800en_HK
dc.identifier.scopusauthoridLee, Y=54385383900en_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK

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