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Article: Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia

TitleAnalgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia
Authors
Keywordsanalgesia
dental
dexmedetomidine
intranasal
pain
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/
Citation
British Journal Of Anaesthesia, 2011, v. 107 n. 3, p. 430-437 How to Cite?
AbstractBackground Dexmedetomidine (DEX) is an alpha 2-adrenoreceptor agonist, which induces sedation and analgesia. This study aimed to determine whether intranasal DEX offered perioperative sedation and better postoperative analgesia. Methods Patients having unilateral third molar surgery under local anaesthesia were recruited and allocated to receive either intranasal DEX 1 μg kg-1 (Group D) or same volume of saline (Group P) 45 min before surgery. Patient-controlled sedation with propofol was offered as a rescue sedative. Perioperative sedation, postoperative pain relief and analgesic consumption, vital signs, adverse events, postoperative recovery, and satisfaction in sedation and analgesia were assessed. Results Thirty patients from each group were studied. Areas under curve (AUC) of postoperative numerical rating scale (NRS) pain scores 1-12 h at rest and during mouth opening were significantly lower in Group D (P=0.003 and 0.009, respectively). AUC BIS values and OAA/S sedation scores were significantly lower before surgery and at the recovery area (all P<0.01) with significantly less intra-operative propofol used in group D (P<0.01). In group D, heart rate was significantly lower at recovery period (P=0.005) while systolic blood pressure in different periods of the study (all P<0.01), but the decreases did not require treatment. More patients from placebo group experienced dizziness (P=0.026) but no serious adverse event was found. No difference was found in postoperative psychomotor recovery and satisfaction in pain relief and sedation. Conclusions Patients receiving intranasal DEX for unilateral third molar surgery with local anaesthesia were more sedated perioperatively with better postoperative pain relief. No delay in psychomotor recovery was seen. © The Author [2011].
Persistent Identifierhttp://hdl.handle.net/10722/138938
ISSN
2015 Impact Factor: 5.616
2015 SCImago Journal Rankings: 2.314
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200807176008
Funding Information:

This study was supported in part by a University of Hong Kong CRCG Small Project Fund (200807176008).

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CWen_HK
dc.contributor.authorNg, KFJen_HK
dc.contributor.authorLiu, Jen_HK
dc.contributor.authorYuen, MYVen_HK
dc.contributor.authorHo, MHAen_HK
dc.contributor.authorIrwin, MGen_HK
dc.date.accessioned2011-09-23T05:42:21Z-
dc.date.available2011-09-23T05:42:21Z-
dc.date.issued2011en_HK
dc.identifier.citationBritish Journal Of Anaesthesia, 2011, v. 107 n. 3, p. 430-437en_HK
dc.identifier.issn0007-0912en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138938-
dc.description.abstractBackground Dexmedetomidine (DEX) is an alpha 2-adrenoreceptor agonist, which induces sedation and analgesia. This study aimed to determine whether intranasal DEX offered perioperative sedation and better postoperative analgesia. Methods Patients having unilateral third molar surgery under local anaesthesia were recruited and allocated to receive either intranasal DEX 1 μg kg-1 (Group D) or same volume of saline (Group P) 45 min before surgery. Patient-controlled sedation with propofol was offered as a rescue sedative. Perioperative sedation, postoperative pain relief and analgesic consumption, vital signs, adverse events, postoperative recovery, and satisfaction in sedation and analgesia were assessed. Results Thirty patients from each group were studied. Areas under curve (AUC) of postoperative numerical rating scale (NRS) pain scores 1-12 h at rest and during mouth opening were significantly lower in Group D (P=0.003 and 0.009, respectively). AUC BIS values and OAA/S sedation scores were significantly lower before surgery and at the recovery area (all P<0.01) with significantly less intra-operative propofol used in group D (P<0.01). In group D, heart rate was significantly lower at recovery period (P=0.005) while systolic blood pressure in different periods of the study (all P<0.01), but the decreases did not require treatment. More patients from placebo group experienced dizziness (P=0.026) but no serious adverse event was found. No difference was found in postoperative psychomotor recovery and satisfaction in pain relief and sedation. Conclusions Patients receiving intranasal DEX for unilateral third molar surgery with local anaesthesia were more sedated perioperatively with better postoperative pain relief. No delay in psychomotor recovery was seen. © The Author [2011].en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/en_HK
dc.relation.ispartofBritish Journal of Anaesthesiaen_HK
dc.subjectanalgesiaen_HK
dc.subjectdentalen_HK
dc.subjectdexmedetomidineen_HK
dc.subjectintranasalen_HK
dc.subjectpainen_HK
dc.subject.meshAdrenergic alpha-2 Receptor Agonists - pharmacology-
dc.subject.meshAnesthesia, Local-
dc.subject.meshDexmedetomidine - administration and dosage - adverse effects - pharmacology-
dc.subject.meshMolar, Third - surgery-
dc.subject.meshPain, Postoperative - drug therapy-
dc.titleAnalgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0912&volume=107&issue=3&spage=430&epage=437&date=2011&atitle=Analgesic+and+sedative+effects+of+intranasal+dexmedetomidine+in+third+molar+surgery+under+local+anaesthesiaen_US
dc.identifier.emailCheung, CW:cheucw@hku.hken_HK
dc.identifier.emailNg, KFJ:jkfng@hkucc.hku.hken_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.authorityCheung, CW=rp00244en_HK
dc.identifier.authorityNg, KFJ=rp00544en_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/bja/aer164en_HK
dc.identifier.pmid21685111-
dc.identifier.scopuseid_2-s2.0-80051663044en_HK
dc.identifier.hkuros193535en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051663044&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume107en_HK
dc.identifier.issue3en_HK
dc.identifier.spage430en_HK
dc.identifier.epage437en_HK
dc.identifier.eissn1471-6771-
dc.identifier.isiWOS:000293910400019-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.citeulike9713930-

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