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Article: Non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats

TitleNon-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats
Authors
Issue Date2011
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.asp
Citation
Free Radical Research, 2011, v. 45 n. 2, p. 201-210 How to Cite?
AbstractThis study was to explore whether repeated non-invasive limb ischemic pre-conditioning (NLIP) can confer an equivalent cardioprotection against myocardial ischemia-reperfusion (I/R) injury in acute diabetic rats to the extent of conventional myocardial ischemic pre-conditioning (MIP) and whether or not the delayed protection of NLIP is mediated by reducing myocardial oxidative stress after ischemia-reperfusion. Streptozotocin-induced diabetic rats were randomized to four groups: Sham group, the I/R group, the MIP group and the NLIP group. Compared with the I/R group, both the NLIP and MIP groups showed an amelioration of ventricular arrhythmia, reduced myocardial infarct size, increased activities of total superoxide dismutase (SOD), manganese-SOD and glutathione peroxidase, increased expression of manganese-SOD mRNA and decreased xanthine oxidase activity and malondialdehyde concentration (All p < 0.05 vs I/R group). It is concluded that non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats. © 2011 Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/138926
ISSN
2015 Impact Factor: 2.949
2015 SCImago Journal Rankings: 1.159
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China (NSFC)81072631
Funding Information:

This research was supported by National Natural Science Foundation of China (NSFC, No. 81072631).

References

 

DC FieldValueLanguage
dc.contributor.authorZhu, XHen_HK
dc.contributor.authorYuan, HJen_HK
dc.contributor.authorWu, YNen_HK
dc.contributor.authorKang, Yen_HK
dc.contributor.authorJiao, JJen_HK
dc.contributor.authorGao, WZen_HK
dc.contributor.authorLiu, YXen_HK
dc.contributor.authorLou, JSen_HK
dc.contributor.authorXia, Zen_HK
dc.date.accessioned2011-09-23T05:42:13Z-
dc.date.available2011-09-23T05:42:13Z-
dc.date.issued2011en_HK
dc.identifier.citationFree Radical Research, 2011, v. 45 n. 2, p. 201-210en_HK
dc.identifier.issn1071-5762en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138926-
dc.description.abstractThis study was to explore whether repeated non-invasive limb ischemic pre-conditioning (NLIP) can confer an equivalent cardioprotection against myocardial ischemia-reperfusion (I/R) injury in acute diabetic rats to the extent of conventional myocardial ischemic pre-conditioning (MIP) and whether or not the delayed protection of NLIP is mediated by reducing myocardial oxidative stress after ischemia-reperfusion. Streptozotocin-induced diabetic rats were randomized to four groups: Sham group, the I/R group, the MIP group and the NLIP group. Compared with the I/R group, both the NLIP and MIP groups showed an amelioration of ventricular arrhythmia, reduced myocardial infarct size, increased activities of total superoxide dismutase (SOD), manganese-SOD and glutathione peroxidase, increased expression of manganese-SOD mRNA and decreased xanthine oxidase activity and malondialdehyde concentration (All p < 0.05 vs I/R group). It is concluded that non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats. © 2011 Informa UK, Ltd.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.aspen_HK
dc.relation.ispartofFree Radical Researchen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshArrhythmias, Cardiac - metabolism - physiopathologyen_HK
dc.subject.meshBlood Pressureen_HK
dc.subject.meshDiabetes Mellitus, Experimental - metabolism - physiopathologyen_HK
dc.subject.meshExtremities - blood supply - physiopathologyen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshGlutathione Peroxidase - metabolismen_HK
dc.subject.meshHemodynamicsen_HK
dc.subject.meshIschemic Preconditioning - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMalondialdehyde - metabolismen_HK
dc.subject.meshModels, Animalen_HK
dc.subject.meshMyocardial Infarction - metabolism - physiopathologyen_HK
dc.subject.meshMyocardial Reperfusion Injury - metabolism - physiopathology - prevention & controlen_HK
dc.subject.meshMyocardium - metabolismen_HK
dc.subject.meshOxidative Stressen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Wistaren_HK
dc.subject.meshStreptozocin - administration & dosageen_HK
dc.subject.meshSuperoxide Dismutase - genetics - metabolismen_HK
dc.subject.meshXanthine Oxidase - metabolismen_HK
dc.titleNon-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic ratsen_HK
dc.typeArticleen_HK
dc.identifier.emailXia, Z:zyxia@hkucc.hku.hken_HK
dc.identifier.authorityXia, Z=rp00532en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/10715762.2010.522576en_HK
dc.identifier.pmid20942563-
dc.identifier.scopuseid_2-s2.0-78651321298en_HK
dc.identifier.hkuros193400en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78651321298&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue2en_HK
dc.identifier.spage201en_HK
dc.identifier.epage210en_HK
dc.identifier.isiWOS:000287090300009-
dc.publisher.placeUnited Kingdomen_HK

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