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Article: Adjuvant analgesics in acute pain

TitleAdjuvant analgesics in acute pain
Authors
Issue Date2011
PublisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eop
Citation
Expert Opinion On Pharmacotherapy, 2011, v. 12 n. 3, p. 363-385 How to Cite?
AbstractIntroduction: Despite its central role in acute pain management, the exclusive use of opioids has been challenged recently in view of its immediate and long-term side effects. Development of chronic postsurgical pain syndromes, hyperalgesia and immunomodulation are some particular concerns as they may be related to opioid exposure, intertwined with patient characteristics and other factors. Application of a multimodal approach, administration of preventive analgesia and paradigm shift in surgical techniques all mandate a revisit of evidence-based perioperative pain management. Areas covered: Adjuvant analgesics are drugs indicated for primary non-pain conditions, but have been found efficacious in analgesia either when used alone or in combination with other analgesics. Among a diverse group of adjuvant analgesics, systemic administration of ketamine, magnesium, gabapentinoids, steroids, α2 agonists and lidocaine are reviewed, with recent evidence compared with earlier systematic reviews or meta-analyses from a Medline search (1990-Apr 2010). Expert opinion: For acute pain management, adjuvant analgesics in appropriate doses and monitored care are beneficial in improving analgesic efficacy and reduce opioid-related side effects with good safety and tolerability. However, the quest for an optimal regime for administration and individualizing treatment remains. © 2011 Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/138921
ISSN
2015 Impact Factor: 3.543
2015 SCImago Journal Rankings: 0.884
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLui, Fen_HK
dc.contributor.authorNg, KFJen_HK
dc.date.accessioned2011-09-23T05:42:04Z-
dc.date.available2011-09-23T05:42:04Z-
dc.date.issued2011en_HK
dc.identifier.citationExpert Opinion On Pharmacotherapy, 2011, v. 12 n. 3, p. 363-385en_HK
dc.identifier.issn1465-6566en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138921-
dc.description.abstractIntroduction: Despite its central role in acute pain management, the exclusive use of opioids has been challenged recently in view of its immediate and long-term side effects. Development of chronic postsurgical pain syndromes, hyperalgesia and immunomodulation are some particular concerns as they may be related to opioid exposure, intertwined with patient characteristics and other factors. Application of a multimodal approach, administration of preventive analgesia and paradigm shift in surgical techniques all mandate a revisit of evidence-based perioperative pain management. Areas covered: Adjuvant analgesics are drugs indicated for primary non-pain conditions, but have been found efficacious in analgesia either when used alone or in combination with other analgesics. Among a diverse group of adjuvant analgesics, systemic administration of ketamine, magnesium, gabapentinoids, steroids, α2 agonists and lidocaine are reviewed, with recent evidence compared with earlier systematic reviews or meta-analyses from a Medline search (1990-Apr 2010). Expert opinion: For acute pain management, adjuvant analgesics in appropriate doses and monitored care are beneficial in improving analgesic efficacy and reduce opioid-related side effects with good safety and tolerability. However, the quest for an optimal regime for administration and individualizing treatment remains. © 2011 Informa UK, Ltd.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eopen_HK
dc.relation.ispartofExpert Opinion on Pharmacotherapyen_HK
dc.rightsExpert Opinion on Pharmacotherapy. Copyright © Informa Healthcare.-
dc.subject.meshAcute Diseaseen_HK
dc.subject.meshAnalgesics - administration & dosage - adverse effects - therapeutic useen_HK
dc.subject.meshAnalgesics, Opioid - administration & dosage - adverse effects - therapeutic useen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshEvidence-Based Medicineen_HK
dc.subject.meshHumansen_HK
dc.subject.meshPain - drug therapy - physiopathologyen_HK
dc.subject.meshPain, Postoperative - drug therapy - physiopathologyen_HK
dc.titleAdjuvant analgesics in acute painen_HK
dc.typeArticleen_HK
dc.identifier.emailNg, KFJ: jkfng@hku.hken_HK
dc.identifier.authorityNg, KFJ=rp00544en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1517/14656566.2011.521743en_HK
dc.identifier.pmid21254945-
dc.identifier.scopuseid_2-s2.0-79251518316en_HK
dc.identifier.hkuros192020en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79251518316&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue3en_HK
dc.identifier.spage363en_HK
dc.identifier.epage385en_HK
dc.identifier.isiWOS:000286937200004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.citeulike8768279-

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