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Article: Are postoperative intravenous antibiotics necessary after bimaxillary orthognathic surgery? A prospective, randomized, double-blind, placebo-controlled clinical trial

TitleAre postoperative intravenous antibiotics necessary after bimaxillary orthognathic surgery? A prospective, randomized, double-blind, placebo-controlled clinical trial
Authors
Issue Date2011
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijom
Citation
International Journal of Oral and Maxillofacial Surgery, 2011, v. 40 n. 12, p. 1363-1368 How to Cite?
AbstractPostoperative antibiotic prophylaxis is often administered intravenously, despite an increased morbidity rate compared with oral application. This study investigates whether a postoperative oral antibiotic regimen is as effective as incorporation of intravenous antibiotics after bimaxillary orthognathic surgery. 42 patients who underwent bimaxillary orthognathic surgery between December 2008 and May 2010 were randomly allocated to 2 placebo-controlled postoperative antibiotic prophylaxis groups. Group 1 received oral amoxicillin 500mg three times daily; group 2 received intravenous ampicillin 1g four times daily, during the first two postoperative days. Both groups subsequently took oral amoxicillin for three more days. Clinically, the infection rate was assessed in both study groups for a period of 6 weeks after the surgery. 9 patients (21.4%) developed infection. No adverse drug event was detected. No significant difference (p=0.45) was detected in the infection rate between group 1 (3/21) and group 2 (6/21). Age, type of surgical procedures, duration of the operative procedure, surgical procedure-related events, blood loss, and blood transfusion were all found not related to infection (p>0.05). Administration of more cost-effective oral antibiotic prophylaxis, which causes less comorbidity, can be considered to be safe in bimaxillary orthognathic surgery with segmentalizations.
Persistent Identifierhttp://hdl.handle.net/10722/138884
ISSN
2015 Impact Factor: 1.563
2015 SCImago Journal Rankings: 0.854
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, SKen_HK
dc.contributor.authorLo, J-
dc.contributor.authorZwahlen, RA-
dc.date.accessioned2011-09-23T05:41:39Z-
dc.date.available2011-09-23T05:41:39Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Journal of Oral and Maxillofacial Surgery, 2011, v. 40 n. 12, p. 1363-1368en_HK
dc.identifier.issn0901-5027en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138884-
dc.description.abstractPostoperative antibiotic prophylaxis is often administered intravenously, despite an increased morbidity rate compared with oral application. This study investigates whether a postoperative oral antibiotic regimen is as effective as incorporation of intravenous antibiotics after bimaxillary orthognathic surgery. 42 patients who underwent bimaxillary orthognathic surgery between December 2008 and May 2010 were randomly allocated to 2 placebo-controlled postoperative antibiotic prophylaxis groups. Group 1 received oral amoxicillin 500mg three times daily; group 2 received intravenous ampicillin 1g four times daily, during the first two postoperative days. Both groups subsequently took oral amoxicillin for three more days. Clinically, the infection rate was assessed in both study groups for a period of 6 weeks after the surgery. 9 patients (21.4%) developed infection. No adverse drug event was detected. No significant difference (p=0.45) was detected in the infection rate between group 1 (3/21) and group 2 (6/21). Age, type of surgical procedures, duration of the operative procedure, surgical procedure-related events, blood loss, and blood transfusion were all found not related to infection (p>0.05). Administration of more cost-effective oral antibiotic prophylaxis, which causes less comorbidity, can be considered to be safe in bimaxillary orthognathic surgery with segmentalizations.en_HK
dc.languageengen_US
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijomen_HK
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgeryen_HK
dc.subject.meshAntibiotic Prophylaxisen_HK
dc.subject.meshMandible - surgeryen_HK
dc.subject.meshMaxilla - surgeryen_HK
dc.subject.meshOrthognathic Surgical Procedures - classification - methodsen_HK
dc.subject.meshPostoperative Careen_HK
dc.titleAre postoperative intravenous antibiotics necessary after bimaxillary orthognathic surgery? A prospective, randomized, double-blind, placebo-controlled clinical trialen_HK
dc.typeArticleen_HK
dc.identifier.emailLo, J: drjohnlo@hku.hken_HK
dc.identifier.emailZwahlen, RA: zwahlen@hku.hken_HK
dc.identifier.authorityLo, J=rp00041en_HK
dc.identifier.authorityZwahlen, RA=rp00055en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijom.2011.07.903en_HK
dc.identifier.pmid21871782-
dc.identifier.scopuseid_2-s2.0-82955187556en_HK
dc.identifier.hkuros194858en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-82955187556&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1363en_HK
dc.identifier.epage1368en_HK
dc.identifier.eissn1399-0020-
dc.identifier.isiWOS:000298723700006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZwahlen, RA=7004217269en_HK
dc.identifier.scopusauthoridLo, J=7201650902en_HK
dc.identifier.scopusauthoridTan, SK=54794658200en_HK

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