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Article: Critical review in oral biology & medicine: New approaches to enhanced remineralization of tooth enamel

TitleCritical review in oral biology & medicine: New approaches to enhanced remineralization of tooth enamel
Authors
Keywordscasein phosphopeptide-amorphous calcium phosphate
fluoride
remineralization
Issue Date2010
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2010, v. 89 n. 11, p. 1187-1197 How to Cite?
AbstractDental caries is a highly prevalent diet-related disease and is a major public health problem. A goal of modern dentistry is to manage non-cavitated caries lesions non-invasively through remineralization in an attempt to prevent disease progression and improve aesthetics, strength, and function. Remineralization is defined as the process whereby calcium and phosphate ions are supplied from a source external to the tooth to promote ion deposition into crystal voids in demineralized enamel, to produce net mineral gain. Recently, a range of novel calcium-phosphate-based remineralization delivery systems has been developed for clinical application. These delivery systems include crystalline, unstabilized amorphous, or stabilized amorphous formulations of calcium phosphate. These systems are reviewed, and the technology with the most scientific evidence to support its clinical use is the remineralizing system utilizing casein phosphopeptides to stabilize and deliver bioavailable calcium, phosphate, and fluoride ions. The recent clinical evidence for this technology is presented and the mechanism of action discussed. Biomimetic approaches to stabilization of bioavailable calcium, phosphate, and fluoride ions and the localization of these ions to non-cavitated caries lesions for controlled remineralization show promise for the non-invasive management of dental caries. © 2010 International & American Associations for Dental Research.
Persistent Identifierhttp://hdl.handle.net/10722/138688
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCochrane, NJen_HK
dc.contributor.authorCai, Fen_HK
dc.contributor.authorHuq, NLen_HK
dc.contributor.authorBurrow, MFen_HK
dc.contributor.authorReynolds, ECen_HK
dc.date.accessioned2011-09-07T04:02:22Z-
dc.date.available2011-09-07T04:02:22Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Dental Research, 2010, v. 89 n. 11, p. 1187-1197en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138688-
dc.description.abstractDental caries is a highly prevalent diet-related disease and is a major public health problem. A goal of modern dentistry is to manage non-cavitated caries lesions non-invasively through remineralization in an attempt to prevent disease progression and improve aesthetics, strength, and function. Remineralization is defined as the process whereby calcium and phosphate ions are supplied from a source external to the tooth to promote ion deposition into crystal voids in demineralized enamel, to produce net mineral gain. Recently, a range of novel calcium-phosphate-based remineralization delivery systems has been developed for clinical application. These delivery systems include crystalline, unstabilized amorphous, or stabilized amorphous formulations of calcium phosphate. These systems are reviewed, and the technology with the most scientific evidence to support its clinical use is the remineralizing system utilizing casein phosphopeptides to stabilize and deliver bioavailable calcium, phosphate, and fluoride ions. The recent clinical evidence for this technology is presented and the mechanism of action discussed. Biomimetic approaches to stabilization of bioavailable calcium, phosphate, and fluoride ions and the localization of these ions to non-cavitated caries lesions for controlled remineralization show promise for the non-invasive management of dental caries. © 2010 International & American Associations for Dental Research.en_HK
dc.languageeng-
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc..-
dc.subjectcasein phosphopeptide-amorphous calcium phosphateen_HK
dc.subjectfluorideen_HK
dc.subjectremineralizationen_HK
dc.subject.meshCalcium Phosphates - pharmacokinetics - therapeutic use-
dc.subject.meshDental Caries - metabolism - prevention and control-
dc.subject.meshCaseins/pharmacokinetics/therapeutic use-
dc.subject.meshFluorides - pharmacokinetics - therapeutic use-
dc.subject.meshTooth Remineralization - methods-
dc.titleCritical review in oral biology & medicine: New approaches to enhanced remineralization of tooth enamelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=89&issue=11&spage=1187&epage=1197&date=2010&atitle=New+approaches+to+enhanced+remineralization+of+tooth+enamel-
dc.identifier.emailBurrow, MF:mfburr58@hku.hken_HK
dc.identifier.authorityBurrow, MF=rp01306en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0022034510376046en_HK
dc.identifier.pmid20739698-
dc.identifier.scopuseid_2-s2.0-77958545977en_HK
dc.identifier.hkuros186545-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958545977&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1187en_HK
dc.identifier.epage1197en_HK
dc.identifier.isiWOS:000283363300003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCochrane, NJ=14830194400en_HK
dc.identifier.scopusauthoridCai, F=7006714376en_HK
dc.identifier.scopusauthoridHuq, NL=6603964203en_HK
dc.identifier.scopusauthoridBurrow, MF=7005876730en_HK
dc.identifier.scopusauthoridReynolds, EC=35550178300en_HK
dc.identifier.citeulike11016027-

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