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Article: Proteins and direct methods

TitleProteins and direct methods
Authors
Issue Date1991
Citation
Zeitschrift Fur Kristallographie, 1991, v. 197, p. 197-208 How to Cite?
AbstractConventional direct methods, which work so well for small structures, are less successful for macromolecules. Where it has been demonstrated that a solution might be found using direct methods it is then found that the usual figures of merit are unable to distinguish the few good sets of phases from the large number of sets generated. The reasons for the difficulties with very large structures are considered from a first-principles approach taking into account both the factors of having a large number of atoms and low resolution data. A proposal is made for trying to recognize good phase sets by taking a large structure as a sum of a number of smaller structures for each of which a conventional figure of merit can be applied.
Persistent Identifierhttp://hdl.handle.net/10722/138599

 

DC FieldValueLanguage
dc.contributor.authorFan, HFen_US
dc.contributor.authorHao, Qen_US
dc.contributor.authorWoolfson, MMen_US
dc.date.accessioned2011-09-02T06:49:05Z-
dc.date.available2011-09-02T06:49:05Z-
dc.date.issued1991en_US
dc.identifier.citationZeitschrift Fur Kristallographie, 1991, v. 197, p. 197-208en_US
dc.identifier.urihttp://hdl.handle.net/10722/138599-
dc.description.abstractConventional direct methods, which work so well for small structures, are less successful for macromolecules. Where it has been demonstrated that a solution might be found using direct methods it is then found that the usual figures of merit are unable to distinguish the few good sets of phases from the large number of sets generated. The reasons for the difficulties with very large structures are considered from a first-principles approach taking into account both the factors of having a large number of atoms and low resolution data. A proposal is made for trying to recognize good phase sets by taking a large structure as a sum of a number of smaller structures for each of which a conventional figure of merit can be applied.en_US
dc.relation.ispartofZeitschrift Fur Kristallographieen_US
dc.titleProteins and direct methodsen_US
dc.typeArticleen_US
dc.identifier.emailHao, Q: qhao@hku.hken_US
dc.identifier.authorityHao, Q=rp01332en_US
dc.identifier.volume197en_US
dc.identifier.spage197en_US
dc.identifier.epage208en_US

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