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Article: Developmental distribution of vestibular nuclear neurons responsive to different speeds of horizontal translation

TitleDevelopmental distribution of vestibular nuclear neurons responsive to different speeds of horizontal translation
Authors
KeywordsFos
Immunocytohemistry
Linear acceleration
Utricle
Vestibular nuclei
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2010, v. 1326, p. 62-67 How to Cite?
AbstractTo examine whether subgroups of vestibular nuclear neurons encode different frequency oscillation of horizontal linear motion, Fos immunohistochemistry was used to document neuronal subpopulations that were functionally activated by such otolithic stimulations. Conscious rats at P7, P14 and adult were subjected to sinusoidal linear acceleration along the transverse axis on the horizontal plane. Labyrinthectomized and/or stationary controls showed only sporadically scattered Fos-labeled neurons in the vestibular nuclei, confirming otolithic origin of c-fos expression. In each age group, Fos-labeled neurons responsive to high frequency stimulation (> 1.5 Hz) were clustered in the lateral region of the medial vestibular nucleus while those to low frequency stimulation (0.5-1.0 Hz) were found in the medial portion of the medial vestibular nucleus. The number of these neurons increased with age. No apparent frequency-related distribution pattern of Fos-labeled neurons was observed in other vestibular nuclei and subgroups. Our findings therefore reveal subpopulations of central vestibular neurons responsive to different stimulus frequencies that correspond to head motions ranging from tilt to translation. © 2010 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/138590
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7485/05M
7657/06M
761407M
Funding Information:

The authors are grateful to Simon S.M. Chan for calibration of the mechanical set-up, Kimmy F.L. Tsang for determination of the optimal stimulus. This work was supported by grants of the Hong Kong Research Grants Council (HKU7485/05M, 7657/06M, 761407M).

References

 

DC FieldValueLanguage
dc.contributor.authorMa, CWen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorLai, SKen_HK
dc.contributor.authorTse, YCen_HK
dc.contributor.authorYung, KKLen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2011-09-02T01:26:27Z-
dc.date.available2011-09-02T01:26:27Z-
dc.date.issued2010en_HK
dc.identifier.citationBrain Research, 2010, v. 1326, p. 62-67en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138590-
dc.description.abstractTo examine whether subgroups of vestibular nuclear neurons encode different frequency oscillation of horizontal linear motion, Fos immunohistochemistry was used to document neuronal subpopulations that were functionally activated by such otolithic stimulations. Conscious rats at P7, P14 and adult were subjected to sinusoidal linear acceleration along the transverse axis on the horizontal plane. Labyrinthectomized and/or stationary controls showed only sporadically scattered Fos-labeled neurons in the vestibular nuclei, confirming otolithic origin of c-fos expression. In each age group, Fos-labeled neurons responsive to high frequency stimulation (> 1.5 Hz) were clustered in the lateral region of the medial vestibular nucleus while those to low frequency stimulation (0.5-1.0 Hz) were found in the medial portion of the medial vestibular nucleus. The number of these neurons increased with age. No apparent frequency-related distribution pattern of Fos-labeled neurons was observed in other vestibular nuclei and subgroups. Our findings therefore reveal subpopulations of central vestibular neurons responsive to different stimulus frequencies that correspond to head motions ranging from tilt to translation. © 2010 Elsevier B.V. All rights reserved.en_HK
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.subjectFosen_HK
dc.subjectImmunocytohemistryen_HK
dc.subjectLinear accelerationen_HK
dc.subjectUtricleen_HK
dc.subjectVestibular nucleien_HK
dc.subject.meshAcceleration-
dc.subject.meshAge Factors-
dc.subject.meshGravity Sensing - physiology-
dc.subject.meshNeurons - classification - physiology-
dc.subject.meshVestibular Nuclei - cytology - growth and development-
dc.titleDevelopmental distribution of vestibular nuclear neurons responsive to different speeds of horizontal translationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=1326&spage=62&epage=67&date=2010&atitle=Developmental+distribution+of+vestibular+nuclear+neurons+responsive+to+different+speeds+of+horizontal+translation-
dc.identifier.emailLai, CH: chlaib@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.brainres.2010.02.032en_HK
dc.identifier.pmid20167209-
dc.identifier.scopuseid_2-s2.0-77950301321en_HK
dc.identifier.hkuros173270-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950301321&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1326en_HK
dc.identifier.spage62en_HK
dc.identifier.epage67en_HK
dc.identifier.isiWOS:000277376100006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridMa, CW=15765898900en_HK
dc.identifier.scopusauthoridLai, CH=7403086597en_HK
dc.identifier.scopusauthoridLai, SK=7402937165en_HK
dc.identifier.scopusauthoridTse, YC=7005116869en_HK
dc.identifier.scopusauthoridYung, KKL=13605496000en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK

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