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Book Chapter: Neural crest and Hirschsprung’s disease

TitleNeural crest and Hirschsprung’s disease
Authors
Issue Date2012
PublisherSpringer
Citation
Neural crest and Hirschsprung’s disease. In Srivastava, R & Shankar, S (Eds.), Stem Cells and Human Diseases, p. 353-386. Dordrecht; New York: Springer, 2012 How to Cite?
AbstractNeural crest cells are a transient population of stem cells in vertebrates that give rise to the entire peripheral nervous system (PNS) as well as various non-neural progenies. A peculiar control and coordination of proliferation, migration and differentiation is required for neural crest cells to generate a full diversity of progenies, navigate different organs and establish functional domains in their target organs. Defects in such developmental process may lead to a board spectrum of congenital disorders, and in some cases, also cancer. In this review, we will focus on one specific neurocristopathy in the PNS: the Hirschsprung’s disease (colonic aganglionosis), to emphasize how unraveling the molecular mechanisms underlying the neural crest cell fate determination and progression may facilitate our understanding of the disease etiologies and future development of therapies.
Persistent Identifierhttp://hdl.handle.net/10722/138412
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChow, KHMen_US
dc.contributor.authorTam, PKHen_US
dc.contributor.authorNgan, ESWen_US
dc.date.accessioned2011-08-26T14:52:59Z-
dc.date.available2011-08-26T14:52:59Z-
dc.date.issued2012en_US
dc.identifier.citationNeural crest and Hirschsprung’s disease. In Srivastava, R & Shankar, S (Eds.), Stem Cells and Human Diseases, p. 353-386. Dordrecht; New York: Springer, 2012-
dc.identifier.issn9789400728004-
dc.identifier.urihttp://hdl.handle.net/10722/138412-
dc.description.abstractNeural crest cells are a transient population of stem cells in vertebrates that give rise to the entire peripheral nervous system (PNS) as well as various non-neural progenies. A peculiar control and coordination of proliferation, migration and differentiation is required for neural crest cells to generate a full diversity of progenies, navigate different organs and establish functional domains in their target organs. Defects in such developmental process may lead to a board spectrum of congenital disorders, and in some cases, also cancer. In this review, we will focus on one specific neurocristopathy in the PNS: the Hirschsprung’s disease (colonic aganglionosis), to emphasize how unraveling the molecular mechanisms underlying the neural crest cell fate determination and progression may facilitate our understanding of the disease etiologies and future development of therapies.-
dc.languageengen_US
dc.publisherSpringeren_US
dc.relation.ispartofStem Cells and Human Diseases-
dc.titleNeural crest and Hirschsprung’s diseaseen_US
dc.typeBook_Chapteren_US
dc.identifier.emailChow, KHM: khmchow@hku.hken_US
dc.identifier.emailTam, PKH: paultam@hku.hken_US
dc.identifier.emailNgan, ESW: engan@hku.hken_US
dc.identifier.authorityTam, PKH=rp00060en_US
dc.identifier.authorityNgan, ESW=rp00422en_US
dc.identifier.doi10.1007/978-94-007-2801-1_16-
dc.identifier.hkuros190083en_US
dc.identifier.spage353-
dc.identifier.epage386-
dc.publisher.placeDordrecht; New York-

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