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Article: Injectability of silicone oil-based tamponade agents

TitleInjectability of silicone oil-based tamponade agents
Authors
Issue Date2011
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2011, v. 95 n. 2, p. 273-276 How to Cite?
AbstractBackground/aims: High viscosity silicone oils are used as tamponade agents to increase the resistance to emulsification; however, this makes the oils more difficult to inject. Increasing the extensional viscosity is one way to reduce emulsification. This study aimed to evaluate how silicone oils with increased extensional viscosity behave in terms of their ease of injection. Methods: The shear viscosity and the length of time taken to inject 9 ml of Siluron 1000, Siluron 2000, Siluron 5000, SiliconMate, a 56/44 w/w blend of Siluron 1000/ Siluron 5000 (Blend A) and a 90/10 w/w blend of Siluron 1000/PDMS 423kDa molecular weight (Blend B) were examined. Results: The shear viscosity of Siluron 1000, Siluron 2000 and Siluron 5000 were within the expected ranges. The shear viscosity of Blend A was 2283 mPa s, Blend B was 4710 mPa s and SiliconMate was 995.3 mPa s. Siluron 1000 and SiliconMate had the shortest injection times as expected due to their lower shear viscosities. Comparison of Siluron 2000 and Blend A demonstrated that Siluron 2000 was easier to inject. Similarly, Blend B was easier to inject than Siluron 5000. Conclusion: Silicone oil blends containing small percentages of a high molecular weight additive are easier to inject than single grade oils of the equivalent shear viscosity.
Persistent Identifierhttp://hdl.handle.net/10722/138173
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWilliams, RLen_HK
dc.contributor.authorDay, MJen_HK
dc.contributor.authorGarvey, MJen_HK
dc.contributor.authorMorphis, Gen_HK
dc.contributor.authorIrigoyen, Cen_HK
dc.contributor.authorWong, Den_HK
dc.contributor.authorStappler, Ten_HK
dc.date.accessioned2011-08-26T14:42:23Z-
dc.date.available2011-08-26T14:42:23Z-
dc.date.issued2011en_HK
dc.identifier.citationBritish Journal Of Ophthalmology, 2011, v. 95 n. 2, p. 273-276en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138173-
dc.description.abstractBackground/aims: High viscosity silicone oils are used as tamponade agents to increase the resistance to emulsification; however, this makes the oils more difficult to inject. Increasing the extensional viscosity is one way to reduce emulsification. This study aimed to evaluate how silicone oils with increased extensional viscosity behave in terms of their ease of injection. Methods: The shear viscosity and the length of time taken to inject 9 ml of Siluron 1000, Siluron 2000, Siluron 5000, SiliconMate, a 56/44 w/w blend of Siluron 1000/ Siluron 5000 (Blend A) and a 90/10 w/w blend of Siluron 1000/PDMS 423kDa molecular weight (Blend B) were examined. Results: The shear viscosity of Siluron 1000, Siluron 2000 and Siluron 5000 were within the expected ranges. The shear viscosity of Blend A was 2283 mPa s, Blend B was 4710 mPa s and SiliconMate was 995.3 mPa s. Siluron 1000 and SiliconMate had the shortest injection times as expected due to their lower shear viscosities. Comparison of Siluron 2000 and Blend A demonstrated that Siluron 2000 was easier to inject. Similarly, Blend B was easier to inject than Siluron 5000. Conclusion: Silicone oil blends containing small percentages of a high molecular weight additive are easier to inject than single grade oils of the equivalent shear viscosity.en_HK
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.rightsBritish Journal of Ophthalmology. Copyright © BMJ Publishing Group.-
dc.subject.meshEmulsions-
dc.subject.meshInjections, Intraocular - instrumentation-
dc.subject.meshMolecular Weight-
dc.subject.meshSilicone Oils - administration and dosage - chemistry-
dc.subject.meshViscosity-
dc.titleInjectability of silicone oil-based tamponade agentsen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/bjo.2010.192344en_HK
dc.identifier.pmid21071759-
dc.identifier.scopuseid_2-s2.0-79151476444en_HK
dc.identifier.hkuros191508en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79151476444&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue2en_HK
dc.identifier.spage273en_HK
dc.identifier.epage276en_HK
dc.identifier.isiWOS:000286458700025-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWilliams, RL=10042153900en_HK
dc.identifier.scopusauthoridDay, MJ=24767294300en_HK
dc.identifier.scopusauthoridGarvey, MJ=7102440425en_HK
dc.identifier.scopusauthoridMorphis, G=36797414700en_HK
dc.identifier.scopusauthoridIrigoyen, C=23473053000en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.scopusauthoridStappler, T=8563727800en_HK

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