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Article: Sub-macular surgery: Is still an option for age-related macular degeneration?

TitleSub-macular surgery: Is still an option for age-related macular degeneration?
Authors
KeywordsAge-related macular degeneration
Choroidal transplant
Retinal pigment epithelium
Submacular surgery
Issue Date2011
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdt/index.htm
Citation
Current Drug Targets, 2011, v. 12 n. 2, p. 190-198 How to Cite?
AbstractPurpose: This review summarizes the data reported in peer-reviewed literature on the effects of submacular surgery for age-related macular degeneration (AMD) associated with choriodal neovascularization (CNV). Methods: A review of the MEDLINE database has been performed in order to examine the therapeutic effects of submacular surgical treatments in patients affected by AMD. Results: The multicenter studies conducted by the Submacular Surgery Trials Research Group compare the removal of the CNV complex, both with (336) and without blood (454), with observation in patients affected by AMD. At a 1-year follow-up, no benefit in preventing visual loss had been shown. Furthermore, complications occurred in the surgery arm such as retinal detachment and lens opacification. No differences have been found between submacular surgery and laser photocoagulation in terms of visual acuity and quality of life. As yet, there are no randomized controlled trials concerning retinal pigment epithelium and choroid translocation or macular translocation, but only prospective, non-controlled case series with low quality of evidence. Conclusions: No evidence of potential benefit from submacular removal of the CNV complex due to AMD has been shown. Randomized clinical trails (RCT) concerning other submacular surgical approaches are not available. There are sufficient non-comparative data on retinal pigment epithelium (RPE) graft to warrant an RCT especially in patients with large subretinal haemorrhages, RPE rip or in Anti-VEGF non-responders. © 2010 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/138172
ISSN
2015 Impact Factor: 3.029
2015 SCImago Journal Rankings: 1.211
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRomano, MRen_HK
dc.contributor.authorValldeperas, Xen_HK
dc.contributor.authorVinciguerra, Pen_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2011-08-26T14:42:22Z-
dc.date.available2011-08-26T14:42:22Z-
dc.date.issued2011en_HK
dc.identifier.citationCurrent Drug Targets, 2011, v. 12 n. 2, p. 190-198en_HK
dc.identifier.issn1389-4501en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138172-
dc.description.abstractPurpose: This review summarizes the data reported in peer-reviewed literature on the effects of submacular surgery for age-related macular degeneration (AMD) associated with choriodal neovascularization (CNV). Methods: A review of the MEDLINE database has been performed in order to examine the therapeutic effects of submacular surgical treatments in patients affected by AMD. Results: The multicenter studies conducted by the Submacular Surgery Trials Research Group compare the removal of the CNV complex, both with (336) and without blood (454), with observation in patients affected by AMD. At a 1-year follow-up, no benefit in preventing visual loss had been shown. Furthermore, complications occurred in the surgery arm such as retinal detachment and lens opacification. No differences have been found between submacular surgery and laser photocoagulation in terms of visual acuity and quality of life. As yet, there are no randomized controlled trials concerning retinal pigment epithelium and choroid translocation or macular translocation, but only prospective, non-controlled case series with low quality of evidence. Conclusions: No evidence of potential benefit from submacular removal of the CNV complex due to AMD has been shown. Randomized clinical trails (RCT) concerning other submacular surgical approaches are not available. There are sufficient non-comparative data on retinal pigment epithelium (RPE) graft to warrant an RCT especially in patients with large subretinal haemorrhages, RPE rip or in Anti-VEGF non-responders. © 2010 Bentham Science Publishers Ltd.en_HK
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdt/index.htmen_HK
dc.relation.ispartofCurrent Drug Targetsen_HK
dc.subjectAge-related macular degenerationen_HK
dc.subjectChoroidal transplanten_HK
dc.subjectRetinal pigment epitheliumen_HK
dc.subjectSubmacular surgeryen_HK
dc.subject.meshBlindness - etiology - prevention and control-
dc.subject.meshChoroidal Neovascularization - surgery-
dc.subject.meshMacula Lutea-
dc.subject.meshRetina - surgery-
dc.subject.meshWet Macular Degeneration - surgery-
dc.titleSub-macular surgery: Is still an option for age-related macular degeneration?en_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/138945011794182700en_HK
dc.identifier.pmid20887243-
dc.identifier.scopuseid_2-s2.0-79955644519en_HK
dc.identifier.hkuros191507en_US
dc.identifier.hkuros212093-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955644519&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue2en_HK
dc.identifier.spage190en_HK
dc.identifier.epage198en_HK
dc.identifier.isiWOS:000287299000006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridRomano, MR=35249070500en_HK
dc.identifier.scopusauthoridValldeperas, X=14018791900en_HK
dc.identifier.scopusauthoridVinciguerra, P=7004320954en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.citeulike8620499-

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