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Article: Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes

TitleAdjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes
Authors
Issue Date2011
PublisherBioScientifica Ltd. The Journal's web site is located at http://www.reproduction-online.org
Citation
Reproduction, 2011, v. 141 n. 5, p. 571-580 How to Cite?
AbstractAdjudin is a derivative of 1H-indazole-3-carboxylic acid that was shown to have potent anti-spermatogenic activity in rats, rabbits, and dogs. It exerts its effects most notably locally in the apical compartment of the seminiferous epithelium, behind the blood-testis barrier, by disrupting adhesion of germ cells, most notably spermatids to the Sertoli cells, thereby inducing release of immature spermatids from the epithelium that leads to infertility. After adjudin is metabolized, the remaining spermatogonial stem cells and spermatogonia repopulate the seminiferous epithelium gradually via spermatogonial self-renewal and differentiation, to be followed by meiosis and spermiogenesis, and thus fertility rebounds. Recent studies in rats have demonstrated unequivocally that the primary and initial cellular target of adjudin in the testis is the apical ectoplasmic specialization, a testis-specific anchoring junction type restricted to the interface between Sertoli cells and elongating spermatids (from step 8 to 19 spermatids). In this review, we highlight some of the recent advances and obstacles regarding the possible use of adjudin as a male contraceptive. © 2011 Society for Reproduction and Fertility.
Persistent Identifierhttp://hdl.handle.net/10722/138077
ISSN
2015 Impact Factor: 3.184
2015 SCImago Journal Rankings: 1.472
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of Health (National Institute of Child Health and Human Development)R01 HD056034
R01 HD056034-02S1
U54 HD029990
R03 HD061401
Hong Kong Research Grants CouncilHKU771507
HKU772009
Funding Information:

Studies in the authors' laboratory were supported by grants from the National Institutes of Health (National Institute of Child Health and Human Development, R01 HD056034 and R01 HD056034-02S1 to C Y Cheng; U54 HD029990 Project 5 to C Y Cheng; and R03 HD061401 to D D Mruk). W-Y Lui was supported by Hong Kong Research Grants Council (HKU771507 and HKU772009).

References

 

DC FieldValueLanguage
dc.contributor.authorMok, KWen_HK
dc.contributor.authorMruk, DDen_HK
dc.contributor.authorLie, PPYen_HK
dc.contributor.authorLui, WYen_HK
dc.contributor.authorCheng, CYen_HK
dc.date.accessioned2011-08-26T14:39:42Z-
dc.date.available2011-08-26T14:39:42Z-
dc.date.issued2011en_HK
dc.identifier.citationReproduction, 2011, v. 141 n. 5, p. 571-580en_HK
dc.identifier.issn1470-1626en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138077-
dc.description.abstractAdjudin is a derivative of 1H-indazole-3-carboxylic acid that was shown to have potent anti-spermatogenic activity in rats, rabbits, and dogs. It exerts its effects most notably locally in the apical compartment of the seminiferous epithelium, behind the blood-testis barrier, by disrupting adhesion of germ cells, most notably spermatids to the Sertoli cells, thereby inducing release of immature spermatids from the epithelium that leads to infertility. After adjudin is metabolized, the remaining spermatogonial stem cells and spermatogonia repopulate the seminiferous epithelium gradually via spermatogonial self-renewal and differentiation, to be followed by meiosis and spermiogenesis, and thus fertility rebounds. Recent studies in rats have demonstrated unequivocally that the primary and initial cellular target of adjudin in the testis is the apical ectoplasmic specialization, a testis-specific anchoring junction type restricted to the interface between Sertoli cells and elongating spermatids (from step 8 to 19 spermatids). In this review, we highlight some of the recent advances and obstacles regarding the possible use of adjudin as a male contraceptive. © 2011 Society for Reproduction and Fertility.en_HK
dc.languageengen_US
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://www.reproduction-online.orgen_HK
dc.relation.ispartofReproductionen_HK
dc.subject.meshContraceptive Agents, Male - pharmacology - toxicity-
dc.subject.meshHydrazines - pharmacology - toxicity-
dc.subject.meshIndazoles - pharmacology - toxicity-
dc.subject.meshSpermatogenesis - drug effects-
dc.subject.meshSpermatozoa - drug effects-
dc.titleAdjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testesen_HK
dc.typeArticleen_HK
dc.identifier.emailLui, WY: wylui@hku.hken_HK
dc.identifier.authorityLui, WY=rp00756en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1530/REP-10-0464en_HK
dc.identifier.pmid21307270-
dc.identifier.scopuseid_2-s2.0-79955824328en_HK
dc.identifier.hkuros191897en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955824328&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume141en_HK
dc.identifier.issue5en_HK
dc.identifier.spage571en_HK
dc.identifier.epage580en_HK
dc.identifier.isiWOS:000290910700003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMok, KW=38961643800en_HK
dc.identifier.scopusauthoridMruk, DD=6701823934en_HK
dc.identifier.scopusauthoridLie, PPY=15839862700en_HK
dc.identifier.scopusauthoridLui, WY=35220192400en_HK
dc.identifier.scopusauthoridCheng, CY=7404797787en_HK

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