File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Survival advantage of primary liver transplantation for resectable hepatocellular carcinoma with vascular invasion within up-to-7 criteria

TitleSurvival advantage of primary liver transplantation for resectable hepatocellular carcinoma with vascular invasion within up-to-7 criteria
Authors
KeywordsMedical sciences
Surgery medical sciences
Allergology and immunology
Issue Date2011
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJT
Citation
The 2011 American Transplant Congress (ATC), Philadelphia, PA., 30 April-4 May 2011. In American Journal of Transplantation, 2011, v. 11 suppl. 2, p. 467, abstract no. 1504 How to Cite?
AbstractBACKGROUND: Vascular invasion is a poor prognostic factor of liver resection (LR) and liver transplantation (LT) for hepatocellular carcinoma (HCC). Microvascular invasion when demonstrable in the LR specimen is paradoxically considered an indication for LT. METHODS: From July 2000 to June 2009, adult patients who underwent LT and LR as primary treatment for HCC were included. Patients who receieved local ablative therapies before LT, before or during LR were excluded. Patient with neoadjuvant systemic chemotherapy, targeted therapy, with positive resection margins were also excluded. RESULTS: This study included 95 recipients who had LT and 620 patients who underwent LR. Among the LT recipients 81% were within up-to-7 criteria, 77% within UCSF criteria. Slightly over one quarter (26.3%) had HCC with either macro- or micro-vascular invasion. About three-quarter (73.7%) were of living donor liver transplantation. 5-year overall survival of 82% was achieved. Within up-to-7 criteria (n=75), the 5-year survival improved to 85.3%. The presence or absence of vascular invasion had comparable survivals (5-year overall survival, 88.2% vs. 84.7% respectively). Those LT recipients with HCC with vascular invasion had survival comparable to those LR patients with HCC without vascular invasion (88.2% vs. 78.9%, p=0.828) These LR patient had 5-year survivals much better than those with vascular invasion who under LR (47.3%). Thus, the signifi cant survival advantage of LT over LR for HCC with vascular invasi…
DescriptionThis journal suppl. is Special Issue of the 2011 American Transplant Congress
Poster Session - P78-IV: abstract no. 1504
Persistent Identifierhttp://hdl.handle.net/10722/137912
ISSN
2015 Impact Factor: 5.669
2015 SCImago Journal Rankings: 2.792

 

DC FieldValueLanguage
dc.contributor.authorChan, SCen_US
dc.contributor.authorLo, CM-
dc.contributor.authorChok, KSH-
dc.contributor.authorSharr, WW-
dc.contributor.authorDai, JW-
dc.contributor.authorFan, ST-
dc.date.accessioned2011-08-26T14:36:49Z-
dc.date.available2011-08-26T14:36:49Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 American Transplant Congress (ATC), Philadelphia, PA., 30 April-4 May 2011. In American Journal of Transplantation, 2011, v. 11 suppl. 2, p. 467, abstract no. 1504en_US
dc.identifier.issn1600-6135-
dc.identifier.urihttp://hdl.handle.net/10722/137912-
dc.descriptionThis journal suppl. is Special Issue of the 2011 American Transplant Congress-
dc.descriptionPoster Session - P78-IV: abstract no. 1504-
dc.description.abstractBACKGROUND: Vascular invasion is a poor prognostic factor of liver resection (LR) and liver transplantation (LT) for hepatocellular carcinoma (HCC). Microvascular invasion when demonstrable in the LR specimen is paradoxically considered an indication for LT. METHODS: From July 2000 to June 2009, adult patients who underwent LT and LR as primary treatment for HCC were included. Patients who receieved local ablative therapies before LT, before or during LR were excluded. Patient with neoadjuvant systemic chemotherapy, targeted therapy, with positive resection margins were also excluded. RESULTS: This study included 95 recipients who had LT and 620 patients who underwent LR. Among the LT recipients 81% were within up-to-7 criteria, 77% within UCSF criteria. Slightly over one quarter (26.3%) had HCC with either macro- or micro-vascular invasion. About three-quarter (73.7%) were of living donor liver transplantation. 5-year overall survival of 82% was achieved. Within up-to-7 criteria (n=75), the 5-year survival improved to 85.3%. The presence or absence of vascular invasion had comparable survivals (5-year overall survival, 88.2% vs. 84.7% respectively). Those LT recipients with HCC with vascular invasion had survival comparable to those LR patients with HCC without vascular invasion (88.2% vs. 78.9%, p=0.828) These LR patient had 5-year survivals much better than those with vascular invasion who under LR (47.3%). Thus, the signifi cant survival advantage of LT over LR for HCC with vascular invasi…-
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJT-
dc.relation.ispartofAmerican Journal of Transplantationen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectMedical sciences-
dc.subjectSurgery medical sciences-
dc.subjectAllergology and immunology-
dc.titleSurvival advantage of primary liver transplantation for resectable hepatocellular carcinoma with vascular invasion within up-to-7 criteriaen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailSharr, WW: wwsharr@hku.hk-
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1600-6143.2011.03534.x-
dc.identifier.hkuros190268en_US
dc.identifier.volume11-
dc.identifier.issuesuppl. 2-
dc.identifier.spage467-
dc.identifier.epage467-
dc.publisher.placeDenmark-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats