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Conference Paper: Dendritic cell function and T cell responses to influenza viruses in patients with X-Linked agammaglobulinemia

TitleDendritic cell function and T cell responses to influenza viruses in patients with X-Linked agammaglobulinemia
Authors
KeywordsMedical sciences
Allergology and immunology
Issue Date2011
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
The 98th Annual Meeting of the American Association of Immunologists (Immunology 2011), San Francisco, CA., 13-17 May 2011. In Journal of Immunology, 2011, v. 186 meeting abstracts suppl., abstract no. 106.12 How to Cite?
AbstractImmunodeficiency patients have high risks for influenza infection. X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by the deficiency of humoral immunity. Hence, cellular immune response becomes more important for these patients. However, little is known about the non-humoral immune responses to influenza virus in XLA patients. Here, we examined the APC function and T-cell immune responses to influenza viruses in XLA patients. Monocyte-derived immature dendritic cells (imMDDCs) from XLA patients had normal maturation upon inactivated influenza virus stimulation in terms of surface molecule expressions and cytokine productions. The T-cell stimulatory capacity of influenza virus-treated imMDDCs determined by mixed lymphocyte reactions from XLA patients was also similar as that from normal controls. There were no obvious side effects in XLA patients after administration of trivalent inactivated influenza vaccine (TIV). TIV significantly induced influenza virus-specific CD4 and CD8 T-cell responses in XLA patients. The frequencies of influenza virus-specific memory/effector CD4 and CD8 T cells in XLA patients are comparable to that in normal controls during 6 months of observation after vaccination. Our results indicated that XLA patients have normal APC function and T cell responses to influenza virus. Influenza vaccination may provide some benefits to XLA patients for influenza infection, at least reducing the severity of illness.
DescriptionOpen Access Journal
Block Symposium: Immunotherapy and Vaccines: Infectious Diseases I
Persistent Identifierhttp://hdl.handle.net/10722/137873
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549

 

DC FieldValueLanguage
dc.contributor.authorLiu, Yen_US
dc.contributor.authorWu, Yen_US
dc.contributor.authorTu, Wen_US
dc.contributor.authorLau, YL-
dc.date.accessioned2011-08-26T14:35:55Z-
dc.date.available2011-08-26T14:35:55Z-
dc.date.issued2011en_US
dc.identifier.citationThe 98th Annual Meeting of the American Association of Immunologists (Immunology 2011), San Francisco, CA., 13-17 May 2011. In Journal of Immunology, 2011, v. 186 meeting abstracts suppl., abstract no. 106.12en_US
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/137873-
dc.descriptionOpen Access Journal-
dc.descriptionBlock Symposium: Immunotherapy and Vaccines: Infectious Diseases I-
dc.description.abstractImmunodeficiency patients have high risks for influenza infection. X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by the deficiency of humoral immunity. Hence, cellular immune response becomes more important for these patients. However, little is known about the non-humoral immune responses to influenza virus in XLA patients. Here, we examined the APC function and T-cell immune responses to influenza viruses in XLA patients. Monocyte-derived immature dendritic cells (imMDDCs) from XLA patients had normal maturation upon inactivated influenza virus stimulation in terms of surface molecule expressions and cytokine productions. The T-cell stimulatory capacity of influenza virus-treated imMDDCs determined by mixed lymphocyte reactions from XLA patients was also similar as that from normal controls. There were no obvious side effects in XLA patients after administration of trivalent inactivated influenza vaccine (TIV). TIV significantly induced influenza virus-specific CD4 and CD8 T-cell responses in XLA patients. The frequencies of influenza virus-specific memory/effector CD4 and CD8 T cells in XLA patients are comparable to that in normal controls during 6 months of observation after vaccination. Our results indicated that XLA patients have normal APC function and T cell responses to influenza virus. Influenza vaccination may provide some benefits to XLA patients for influenza infection, at least reducing the severity of illness.-
dc.languageengen_US
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org-
dc.relation.ispartofJournal of Immunologyen_US
dc.subjectMedical sciences-
dc.subjectAllergology and immunology-
dc.titleDendritic cell function and T cell responses to influenza viruses in patients with X-Linked agammaglobulinemiaen_US
dc.typeConference_Paperen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1767&volume=186&issue=Meeting Abstracts Suppl.&spage=abstract no. 106.2&epage=&date=2011&atitle=Dendritic+cell+function+and+T+cell+responses+to+influenza+viruses+in+patients+with+X-Linked+agammaglobulinemia-
dc.identifier.emailLiu, Y: yinpingl@hku.hken_US
dc.identifier.emailWu, Y: zacharywu03@yahoo.com.hken_US
dc.identifier.emailTu, W: wwtu@hku.hken_US
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.authorityLiu, Y=rp00269en_US
dc.identifier.authorityTu, W=rp00416en_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros191492en_US
dc.identifier.volume186-
dc.identifier.issuemeeting abstracts suppl.-
dc.description.otherThe 98th Annual Meeting of the American Association of Immunologists (Immunology 2011), San Francisco, CA., 13-17 May 2011. In Journal of Immunology, 2011, v. 186 Meeting Abstracts Suppl., abstract no. 106.12-

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