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Conference Paper: Kruppel-like factor 4 suppresses neuroblastoma growth by promoting smooth-muscle differentiation

TitleKruppel-like factor 4 suppresses neuroblastoma growth by promoting smooth-muscle differentiation
Authors
Issue Date2011
PublisherInternational Society for Stem Cell Research (ISSCR). The Conference abstracts' website is located at http://www.isscr.org/home/annual-meeting/past-future-meetings/isscr-9th-annual-meeting-(2011)
Citation
The 9th Annual Meeting of the International Society for Stem Cell Research (ISSCR 2011), Toronto, Canada, 15-18 June 2011. In Thursday Poster Abstracts, 2011, p. 68 How to Cite?
AbstractNeuroblastoma (NB) is an embryonic tumor and possesses a unique propensity to exhibit either a spontaneous regression or an unrestrained growth. Growing evidence suggests that NB comprises heterogeneous populations of improperly differentiated neural crest cells and a small subset of NB cells behaves as stem cells. Commitment of NB stem cells to the fibromuscular lineage may give a favorable outcome, while to the neuronal lineage results in a malignant tumor progression. Kruppel like factor 4 (KLF4) is one of the key reprogramming factors. Intriguingly, it also possesses paradoxical functions in cancers, either as an oncogene or tumor suppressor dependent of cell context. In this study, we elucidated the roles of KLF4 in the lineage determination of NB stem cells and tumor progression. Quantitative RT-PCR showed that loss of KLF4 expression ...
DescriptionPoster Board Number: 2105
Persistent Identifierhttp://hdl.handle.net/10722/137681

 

DC FieldValueLanguage
dc.contributor.authorTsoi, LSen_US
dc.contributor.authorLau, CSTen_US
dc.contributor.authorTam, Pen_US
dc.contributor.authorNgan, Een_US
dc.date.accessioned2011-08-26T14:31:33Z-
dc.date.available2011-08-26T14:31:33Z-
dc.date.issued2011en_US
dc.identifier.citationThe 9th Annual Meeting of the International Society for Stem Cell Research (ISSCR 2011), Toronto, Canada, 15-18 June 2011. In Thursday Poster Abstracts, 2011, p. 68en_US
dc.identifier.urihttp://hdl.handle.net/10722/137681-
dc.descriptionPoster Board Number: 2105-
dc.description.abstractNeuroblastoma (NB) is an embryonic tumor and possesses a unique propensity to exhibit either a spontaneous regression or an unrestrained growth. Growing evidence suggests that NB comprises heterogeneous populations of improperly differentiated neural crest cells and a small subset of NB cells behaves as stem cells. Commitment of NB stem cells to the fibromuscular lineage may give a favorable outcome, while to the neuronal lineage results in a malignant tumor progression. Kruppel like factor 4 (KLF4) is one of the key reprogramming factors. Intriguingly, it also possesses paradoxical functions in cancers, either as an oncogene or tumor suppressor dependent of cell context. In this study, we elucidated the roles of KLF4 in the lineage determination of NB stem cells and tumor progression. Quantitative RT-PCR showed that loss of KLF4 expression ...-
dc.languageengen_US
dc.publisherInternational Society for Stem Cell Research (ISSCR). The Conference abstracts' website is located at http://www.isscr.org/home/annual-meeting/past-future-meetings/isscr-9th-annual-meeting-(2011)-
dc.relation.ispartofInternational Society for Stem Cell Research Annual Meetingen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleKruppel-like factor 4 suppresses neuroblastoma growth by promoting smooth-muscle differentiationen_US
dc.typeConference_Paperen_US
dc.identifier.emailLau, CST: cynlau@hku.hken_US
dc.identifier.emailTam, P: paultam@hku.hken_US
dc.identifier.emailNgan, E: engan@hku.hken_US
dc.identifier.authorityTam, P=rp00060en_US
dc.identifier.authorityNgan, E=rp00422en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros190069en_US
dc.identifier.spage68-
dc.identifier.epage68-

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