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Article: Biology of hepatic cancer stem cells

TitleBiology of hepatic cancer stem cells
Authors
KeywordsTumor-initiating cells
Self-renewal
MiRNA
Liver cancer
Hepatocellular carcinoma
Chemoresistance
Cancer stem cells
Issue Date2011
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal of Gastroenterology and Hepatology, 2011, v. 26 n. 8, p. 1229-1237 How to Cite?
AbstractHepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy of the liver and is the third most frequent cause of cancer death worldwide. Although advances in HCC detection and treatment have increased the likelihood of a cure at early stages of the disease, HCC remains largely incurable because of late presentation and tumor recurrence. Only 25% of HCC patients are deemed suitable for curative treatment, with the overall survival at just a few months for inoperable patients. Additionally, this disease is particularly difficult to treat because of the high recurrence rate, its chemotherapy-resistant nature and the premalignant nature of surrounding cirrhotic liver disease. In the past few years, compelling evidence has emerged in support of the hierarchic cancer stem cell (CSC)/tumor-initiating cell (T-IC) model for solid tumors, including HCC. Understanding the characteristics and function of CSCs in the liver has also shed light on HCC management and treatment, including the implications for prognosis, prediction and treatment resistance. In this review, a detailed summary of the recent progress in liver CSC research with regard to identification, regulation and therapeutic implications will be discussed.
Persistent Identifierhttp://hdl.handle.net/10722/137622
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
Funding AgencyGrant Number
Cancer Genetics, Research Grant CouncilHKU1/06C
HKU7/CRG/09
HKU5/CRF/08
National Key Sci-Tech Special Project of Infectious Diseases2008ZX1002-022
The University of Hong Kong Strategic Research Theme in Cancer
Funding Information:

We thank members of our laboratory for helpful discussion. Work in our laboratory is partially supported by grants from the Sir Michael and Lady Kadoorie Funded Research into Cancer Genetics, Research Grant Council Collaborative Research Fund (HKU1/06C, HKU7/CRG/09 and HKU5/CRF/08), National Key Sci-Tech Special Project of Infectious Diseases (2008ZX1002-022) and The University of Hong Kong Strategic Research Theme in Cancer.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorTong, CMen_HK
dc.contributor.authorMa, Sen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2011-08-26T14:29:31Z-
dc.date.available2011-08-26T14:29:31Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal of Gastroenterology and Hepatology, 2011, v. 26 n. 8, p. 1229-1237en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137622-
dc.description.abstractHepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy of the liver and is the third most frequent cause of cancer death worldwide. Although advances in HCC detection and treatment have increased the likelihood of a cure at early stages of the disease, HCC remains largely incurable because of late presentation and tumor recurrence. Only 25% of HCC patients are deemed suitable for curative treatment, with the overall survival at just a few months for inoperable patients. Additionally, this disease is particularly difficult to treat because of the high recurrence rate, its chemotherapy-resistant nature and the premalignant nature of surrounding cirrhotic liver disease. In the past few years, compelling evidence has emerged in support of the hierarchic cancer stem cell (CSC)/tumor-initiating cell (T-IC) model for solid tumors, including HCC. Understanding the characteristics and function of CSCs in the liver has also shed light on HCC management and treatment, including the implications for prognosis, prediction and treatment resistance. In this review, a detailed summary of the recent progress in liver CSC research with regard to identification, regulation and therapeutic implications will be discussed.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectTumor-initiating cellsen_HK
dc.subjectSelf-renewalen_HK
dc.subjectMiRNAen_HK
dc.subjectLiver canceren_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectChemoresistanceen_HK
dc.subjectCancer stem cellsen_HK
dc.subject.meshSignal Transductionen_HK
dc.subject.meshNeovascularization, Pathologic - pathologyen_HK
dc.subject.meshNeoplastic Stem Cells - drug effects - metabolism - pathologyen_HK
dc.subject.meshMicroRNAs - metabolismen_HK
dc.subject.meshLiver Neoplasms - blood supply - metabolism - pathology - therapyen_HK
dc.subject.meshCarcinoma, Hepatocellular - blood supply - metabolism - pathology - therapyen_HK
dc.subject.meshDrug Resistance, Neoplasmen_HK
dc.subject.meshLiver Neoplasms - blood supply - metabolism - pathology - therapyen_HK
dc.subject.meshMicroRNAs - metabolismen_HK
dc.subject.meshNeoplastic Stem Cells - drug effects - metabolism - pathologyen_HK
dc.titleBiology of hepatic cancer stem cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailMa, S: sma@pathology.hku.hken_HK
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_HK
dc.identifier.authorityMa, S=rp00506en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2011.06762.xen_HK
dc.identifier.pmid21557770-
dc.identifier.scopuseid_2-s2.0-79960439415en_HK
dc.identifier.hkuros189783en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960439415&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1229en_HK
dc.identifier.epage1237en_HK
dc.identifier.isiWOS:000292908400003-
dc.publisher.placeAustraliaen_HK
dc.relation.projectLiver Transplantation Research Centre: A Multidisciplinary Study for Liver Graft Injury-
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridMa, S=16444895800en_HK
dc.identifier.scopusauthoridTong, CM=46062579200en_HK
dc.identifier.citeulike9569914-

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