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Article: Outcome of laparoscopic resection for colorectal cancer in patients with high operative risk

TitleOutcome of laparoscopic resection for colorectal cancer in patients with high operative risk
Authors
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals Of Surgical Oncology, 2011, v. 18 n. 7, p. 1884-1890 How to Cite?
AbstractBackground. There is general concern that high-risk patients are more susceptible to the adverse effect of pneumoperitoneum and they are often denied laparoscopic surgery. This study investigated the impact of laparoscopic colorectal cancer resection for patients with high operative risk, which was defined as American Society of Anesthesiologist classes 3 and 4. Methods. Three hundred thirty-five consecutive high-risk patients who had colorectal cancer resection by open or laparoscopic surgery were included. The patient and tumor characteristics and operative outcomes were recorded prospectively, and comparison was made between the two groups. Results. Compared to open surgery, patients with laparoscopic resection had a shorter hospital stay (8 [6-12] vs. 6 [4-9] days; P>0.001), less blood loss (200 [100-400] vs. 140 [80-250] mL; P = 0.006), reduced cardiac complication rate (13.2% vs. 3.7%; P = 0.006), overall operative complication rate (36.6% vs. 21.3%; P = 0.006), and a trend toward a lower mortality rate (4.4% vs. 0.9%; P = 0.083). There was no difference in 3-year overall and disease-free survival between two groups. Operative blood loss (P = 0.035; odds ratio = 2.69; 95% confidence interval, 1.00-6.78) and open surgery (P = 0.007; odds ratio = 2.31; 95% confidence interval, 1.26-4.23) were independent factors for occurrence of complication. Conclusions. Laparoscopic colorectal cancer resection is associated with more favorable short-term results and should be recommended as the preferred treatment option for high-risk patients. © Society of Surgical Oncology 2011.
Persistent Identifierhttp://hdl.handle.net/10722/137559
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, JTCen_HK
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorChow, LCYen_HK
dc.contributor.authorFan, JKMen_HK
dc.contributor.authorLo, SHen_HK
dc.date.accessioned2011-08-26T14:27:56Z-
dc.date.available2011-08-26T14:27:56Z-
dc.date.issued2011en_HK
dc.identifier.citationAnnals Of Surgical Oncology, 2011, v. 18 n. 7, p. 1884-1890en_HK
dc.identifier.issn1068-9265en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137559-
dc.description.abstractBackground. There is general concern that high-risk patients are more susceptible to the adverse effect of pneumoperitoneum and they are often denied laparoscopic surgery. This study investigated the impact of laparoscopic colorectal cancer resection for patients with high operative risk, which was defined as American Society of Anesthesiologist classes 3 and 4. Methods. Three hundred thirty-five consecutive high-risk patients who had colorectal cancer resection by open or laparoscopic surgery were included. The patient and tumor characteristics and operative outcomes were recorded prospectively, and comparison was made between the two groups. Results. Compared to open surgery, patients with laparoscopic resection had a shorter hospital stay (8 [6-12] vs. 6 [4-9] days; P>0.001), less blood loss (200 [100-400] vs. 140 [80-250] mL; P = 0.006), reduced cardiac complication rate (13.2% vs. 3.7%; P = 0.006), overall operative complication rate (36.6% vs. 21.3%; P = 0.006), and a trend toward a lower mortality rate (4.4% vs. 0.9%; P = 0.083). There was no difference in 3-year overall and disease-free survival between two groups. Operative blood loss (P = 0.035; odds ratio = 2.69; 95% confidence interval, 1.00-6.78) and open surgery (P = 0.007; odds ratio = 2.31; 95% confidence interval, 1.26-4.23) were independent factors for occurrence of complication. Conclusions. Laparoscopic colorectal cancer resection is associated with more favorable short-term results and should be recommended as the preferred treatment option for high-risk patients. © Society of Surgical Oncology 2011.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.orgen_HK
dc.relation.ispartofAnnals of Surgical Oncologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshColectomy-
dc.subject.meshColorectal Neoplasms - mortality - pathology - surgery-
dc.subject.meshComorbidity-
dc.subject.meshLaparoscopy-
dc.subject.meshPostoperative Complications-
dc.titleOutcome of laparoscopic resection for colorectal cancer in patients with high operative risken_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1068-9265&volume=18&issue=7&spage=1884&epage=1890&date=2011&atitle=Outcome+of+laparoscopic+resection+for+colorectal+cancer+in+patients+with+high+operative+risk-
dc.identifier.emailPoon, JTC: tcjensen@hkucc.hku.hken_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.authorityPoon, JTC=rp01603en_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1245/s10434-010-1530-1en_HK
dc.identifier.pmid21225352en_HK
dc.identifier.scopuseid_2-s2.0-80051544159en_HK
dc.identifier.hkuros191448en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051544159&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1884en_HK
dc.identifier.epage1890en_HK
dc.identifier.isiWOS:000291652000014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPoon, JTC=7005903722en_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.identifier.scopusauthoridChow, LCY=24365858800en_HK
dc.identifier.scopusauthoridFan, JKM=23484820100en_HK
dc.identifier.scopusauthoridLo, SH=15518872700en_HK
dc.identifier.citeulike8683057-

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