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Article: Quantitative analysis of the expression of TGF-alpha and EGFR in papillary thyroid carcinoma: Clinicopathological relevance

TitleQuantitative analysis of the expression of TGF-alpha and EGFR in papillary thyroid carcinoma: Clinicopathological relevance
Authors
KeywordsEGFR
Papillary thyroid carcinoma
TGF-α
Issue Date2011
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.asp
Citation
Pathology, 2011, v. 43 n. 1, p. 40-47 How to Cite?
AbstractAims: There are no quantitative data on the mRNA expression of epidermal growth factor receptor (EGFR) and transformation growth factor alpha (TGF-α) in thyroid carcinoma. The aims of this study were to detect, quantify and analyse the clinicopathological correlations of the expression of these genes in a large cohort of patients with thyroid carcinoma. Methods: EGFR and TGF-α expression were investigated using real time quantitative polymerase chain reaction and immunohistochemistry on 71 papillary thyroid carcinomas (PTCs), 68 paired non-cancer thyroid tissues adjacent to the PTC and 20 benign thyroid lesions. Results: TGF-α and EGFR mRNA increased in PTC when compared with benign thyroid lesions. In many PTCs with high level of expression of TGF-α and EGFR mRNA, the morphological non-cancer tissue adjacent to the cancer also showed high levels of expression of these mRNAs. The levels of expression of mRNA of TGF-α and EGFR correlated with each other and with the level of protein expression. The level of expression of TGF-α mRNA was significantly related to lymphovascular permeation while the expression of EGFR mRNA was related to the pathological subtype of PTC and cancer recurrence. Conclusions: TGF-α and EGFR were overexpressed, correlated with each other and associated with the pathological parameters in papillary thyroid carcinoma. The results provide information for management of thyroid cancer in the era of gene targeting therapy. © 2010 Royal College of Pathologists of Australasia.
Persistent Identifierhttp://hdl.handle.net/10722/137547
ISSN
2015 Impact Factor: 2.968
2015 SCImago Journal Rankings: 1.049
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, AKYen_HK
dc.contributor.authorLau, KKPen_HK
dc.contributor.authorGopalan, Ven_HK
dc.contributor.authorLuk, Jen_HK
dc.contributor.authorLo, CYen_HK
dc.date.accessioned2011-08-26T14:27:50Z-
dc.date.available2011-08-26T14:27:50Z-
dc.date.issued2011en_HK
dc.identifier.citationPathology, 2011, v. 43 n. 1, p. 40-47en_HK
dc.identifier.issn0031-3025en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137547-
dc.description.abstractAims: There are no quantitative data on the mRNA expression of epidermal growth factor receptor (EGFR) and transformation growth factor alpha (TGF-α) in thyroid carcinoma. The aims of this study were to detect, quantify and analyse the clinicopathological correlations of the expression of these genes in a large cohort of patients with thyroid carcinoma. Methods: EGFR and TGF-α expression were investigated using real time quantitative polymerase chain reaction and immunohistochemistry on 71 papillary thyroid carcinomas (PTCs), 68 paired non-cancer thyroid tissues adjacent to the PTC and 20 benign thyroid lesions. Results: TGF-α and EGFR mRNA increased in PTC when compared with benign thyroid lesions. In many PTCs with high level of expression of TGF-α and EGFR mRNA, the morphological non-cancer tissue adjacent to the cancer also showed high levels of expression of these mRNAs. The levels of expression of mRNA of TGF-α and EGFR correlated with each other and with the level of protein expression. The level of expression of TGF-α mRNA was significantly related to lymphovascular permeation while the expression of EGFR mRNA was related to the pathological subtype of PTC and cancer recurrence. Conclusions: TGF-α and EGFR were overexpressed, correlated with each other and associated with the pathological parameters in papillary thyroid carcinoma. The results provide information for management of thyroid cancer in the era of gene targeting therapy. © 2010 Royal College of Pathologists of Australasia.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.aspen_HK
dc.relation.ispartofPathologyen_HK
dc.rightsPathology. Copyright © Informa Healthcare.-
dc.subjectEGFRen_HK
dc.subjectPapillary thyroid carcinomaen_HK
dc.subjectTGF-αen_HK
dc.subject.meshAdenocarcinoma, Papillary - genetics - metabolism - pathology-
dc.subject.meshFluorescent Antibody Technique, Indirect-
dc.subject.meshReceptor, Epidermal Growth Factor - genetics - metabolism-
dc.subject.meshThyroid Neoplasms - genetics - metabolism - pathology-
dc.subject.meshTransforming Growth Factor alpha - genetics - metabolism-
dc.titleQuantitative analysis of the expression of TGF-alpha and EGFR in papillary thyroid carcinoma: Clinicopathological relevanceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0031-3025&volume=43&issue=1&spage=40&epage=47&date=2011&atitle=Quantitative+analysis+of+the+expression+of+TGF-alpha+and+EGFR+in+papillary+thyroid+carcinoma:+clinicopathological+relevance-
dc.identifier.emailLuk, J: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLuk, J=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/PAT.0b013e328340bb46en_HK
dc.identifier.pmid21240064-
dc.identifier.scopuseid_2-s2.0-80052255082en_HK
dc.identifier.hkuros189250en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052255082&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue1en_HK
dc.identifier.spage40en_HK
dc.identifier.epage47en_HK
dc.identifier.isiWOS:000286040500007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, AKY=7403657165en_HK
dc.identifier.scopusauthoridLau, KKP=25121234200en_HK
dc.identifier.scopusauthoridGopalan, V=36156966900en_HK
dc.identifier.scopusauthoridLuk, J=7006777791en_HK
dc.identifier.scopusauthoridLo, CY=16417392800en_HK

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