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Article: No NRG1 V266L in Chinese patients with schizophrenia
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TitleNo NRG1 V266L in Chinese patients with schizophrenia
 
AuthorsGarciaBarceló, MM3
Miao, X3 4
Tang, CS1
So, HC1
Tang, W3
Leon, TYY3
So, M3
Yip, B1 3
Chen, RYL1
Cheung, EFC6
Chen, EYH5
Li, T5 2
Tam, P3
Cherny, SS1 3
Sham, PC3 1
 
Keywordsmutations
neuregulin 1
V266L
 
Issue Date2011
 
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.com
 
CitationPsychiatric Genetics, 2011, v. 21 n. 1, p. 47-49 [How to Cite?]
DOI: http://dx.doi.org/10.1097/YPG.0b013e328341355b
 
AbstractNRG1 is one of the best-supported schizophrenia (SZ) susceptibility genes. A NRG1 V266L missense mutation has been found to be associated with SZ in several populations. V266L is not in linkage disequilibrium with any of the SZ-associated NRG1 haplotypes described thus far, and may represent an independent SZ susceptibility locus within NRG1 gene. V266 is a highly conserved residue and its substitution is predicted to have a deleterious effect on the protein. As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls. V266L was found neither in patients nor in controls. Lack of replication of an association across populations may be because of the differences in linkage disequilibrium structure or allele frequencies. Some true associations may not be replicated regardless of the sample size of the study. © 2011 Wolters Kluwer Health. Lippincott Williams & Wilkins.
 
ISSN0955-8829
2013 Impact Factor: 2.274
2013 SCImago Journal Rankings: 1.106
 
DOIhttp://dx.doi.org/10.1097/YPG.0b013e328341355b
 
ISI Accession Number IDWOS:000285544800008
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU757905
HKU774707
HKU 765609
The University of Hong Kong200811159006
200907176047
University Grants Committee of Hong KongAoE/M-04/04
NIHEY-12562
The University of Hong Kong Genomics Strategic Research Theme
Funding Information:

This work was supported by the research grants HKU757905, HKU774707 to Pak C. Sham and HKU 765609 to Maria-Merce Garcia-Barcelo from the Hong Kong Research Grants Council and The University of Hong Kong Seed Funding Programme for Basic Research No. 200811159006 to Maria-Merce Garcia-Barcelo and The University of Hong Kong Small Project Funding No. 200907176047 to Benjamin Yip. Support was also received from the University Grants Committee of Hong Kong (AoE/M-04/04), the NIH Grant EY-12562 to Stacey S. Cherny and Pak C. Sham and from The University of Hong Kong Genomics Strategic Research Theme.

 
ReferencesReferences in Scopus
 
GrantsDevelopmental genomics and skeletal research
 
DC FieldValue
dc.contributor.authorGarciaBarceló, MM
 
dc.contributor.authorMiao, X
 
dc.contributor.authorTang, CS
 
dc.contributor.authorSo, HC
 
dc.contributor.authorTang, W
 
dc.contributor.authorLeon, TYY
 
dc.contributor.authorSo, M
 
dc.contributor.authorYip, B
 
dc.contributor.authorChen, RYL
 
dc.contributor.authorCheung, EFC
 
dc.contributor.authorChen, EYH
 
dc.contributor.authorLi, T
 
dc.contributor.authorTam, P
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.date.accessioned2011-08-26T14:26:54Z
 
dc.date.available2011-08-26T14:26:54Z
 
dc.date.issued2011
 
dc.description.abstractNRG1 is one of the best-supported schizophrenia (SZ) susceptibility genes. A NRG1 V266L missense mutation has been found to be associated with SZ in several populations. V266L is not in linkage disequilibrium with any of the SZ-associated NRG1 haplotypes described thus far, and may represent an independent SZ susceptibility locus within NRG1 gene. V266 is a highly conserved residue and its substitution is predicted to have a deleterious effect on the protein. As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls. V266L was found neither in patients nor in controls. Lack of replication of an association across populations may be because of the differences in linkage disequilibrium structure or allele frequencies. Some true associations may not be replicated regardless of the sample size of the study. © 2011 Wolters Kluwer Health. Lippincott Williams & Wilkins.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationPsychiatric Genetics, 2011, v. 21 n. 1, p. 47-49 [How to Cite?]
DOI: http://dx.doi.org/10.1097/YPG.0b013e328341355b
 
dc.identifier.doihttp://dx.doi.org/10.1097/YPG.0b013e328341355b
 
dc.identifier.eissn1473-5873
 
dc.identifier.epage49
 
dc.identifier.hkuros189851
 
dc.identifier.isiWOS:000285544800008
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU757905
HKU774707
HKU 765609
The University of Hong Kong200811159006
200907176047
University Grants Committee of Hong KongAoE/M-04/04
NIHEY-12562
The University of Hong Kong Genomics Strategic Research Theme
Funding Information:

This work was supported by the research grants HKU757905, HKU774707 to Pak C. Sham and HKU 765609 to Maria-Merce Garcia-Barcelo from the Hong Kong Research Grants Council and The University of Hong Kong Seed Funding Programme for Basic Research No. 200811159006 to Maria-Merce Garcia-Barcelo and The University of Hong Kong Small Project Funding No. 200907176047 to Benjamin Yip. Support was also received from the University Grants Committee of Hong Kong (AoE/M-04/04), the NIH Grant EY-12562 to Stacey S. Cherny and Pak C. Sham and from The University of Hong Kong Genomics Strategic Research Theme.

 
dc.identifier.issn0955-8829
2013 Impact Factor: 2.274
2013 SCImago Journal Rankings: 1.106
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid20978455
 
dc.identifier.scopuseid_2-s2.0-78650772199
 
dc.identifier.spage47
 
dc.identifier.urihttp://hdl.handle.net/10722/137518
 
dc.identifier.volume21
 
dc.languageeng
 
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.com
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPsychiatric Genetics
 
dc.relation.projectDevelopmental genomics and skeletal research
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAmino Acid Substitution - genetics
 
dc.subject.meshAsian Continental Ancestry Group - genetics
 
dc.subject.meshNeuregulin-1 - genetics
 
dc.subject.meshPolymorphism, Single Nucleotide - genetics
 
dc.subject.meshSchizophrenia - genetics
 
dc.subjectmutations
 
dc.subjectneuregulin 1
 
dc.subjectV266L
 
dc.titleNo NRG1 V266L in Chinese patients with schizophrenia
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. King's College London
  3. The University of Hong Kong
  4. Huazhong University of Science and Technology
  5. Sichuan University
  6. Castle Peak Hospital Hong Kong