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Article: No NRG1 V266L in Chinese patients with schizophrenia

TitleNo NRG1 V266L in Chinese patients with schizophrenia
Authors
Keywordsmutations
neuregulin 1
V266L
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.com
Citation
Psychiatric Genetics, 2011, v. 21 n. 1, p. 47-49 How to Cite?
Abstract
NRG1 is one of the best-supported schizophrenia (SZ) susceptibility genes. A NRG1 V266L missense mutation has been found to be associated with SZ in several populations. V266L is not in linkage disequilibrium with any of the SZ-associated NRG1 haplotypes described thus far, and may represent an independent SZ susceptibility locus within NRG1 gene. V266 is a highly conserved residue and its substitution is predicted to have a deleterious effect on the protein. As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls. V266L was found neither in patients nor in controls. Lack of replication of an association across populations may be because of the differences in linkage disequilibrium structure or allele frequencies. Some true associations may not be replicated regardless of the sample size of the study. © 2011 Wolters Kluwer Health. Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/137518
ISSN
2013 Impact Factor: 2.274
2013 SCImago Journal Rankings: 1.106
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU757905
HKU774707
HKU 765609
The University of Hong Kong200811159006
200907176047
University Grants Committee of Hong KongAoE/M-04/04
NIHEY-12562
The University of Hong Kong Genomics Strategic Research Theme
Funding Information:

This work was supported by the research grants HKU757905, HKU774707 to Pak C. Sham and HKU 765609 to Maria-Merce Garcia-Barcelo from the Hong Kong Research Grants Council and The University of Hong Kong Seed Funding Programme for Basic Research No. 200811159006 to Maria-Merce Garcia-Barcelo and The University of Hong Kong Small Project Funding No. 200907176047 to Benjamin Yip. Support was also received from the University Grants Committee of Hong Kong (AoE/M-04/04), the NIH Grant EY-12562 to Stacey S. Cherny and Pak C. Sham and from The University of Hong Kong Genomics Strategic Research Theme.

References
Grants

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. King's College London
  3. The University of Hong Kong
  4. Huazhong University of Science and Technology
  5. Sichuan University
  6. Castle Peak Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorGarciaBarceló, MMen_HK
dc.contributor.authorMiao, Xen_HK
dc.contributor.authorTang, CSen_HK
dc.contributor.authorSo, HCen_HK
dc.contributor.authorTang, Wen_HK
dc.contributor.authorLeon, TYYen_HK
dc.contributor.authorSo, Men_HK
dc.contributor.authorYip, Ben_HK
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorCheung, EFCen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorLi, Ten_HK
dc.contributor.authorTam, Pen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2011-08-26T14:26:54Z-
dc.date.available2011-08-26T14:26:54Z-
dc.date.issued2011en_HK
dc.identifier.citationPsychiatric Genetics, 2011, v. 21 n. 1, p. 47-49en_HK
dc.identifier.issn0955-8829en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137518-
dc.description.abstractNRG1 is one of the best-supported schizophrenia (SZ) susceptibility genes. A NRG1 V266L missense mutation has been found to be associated with SZ in several populations. V266L is not in linkage disequilibrium with any of the SZ-associated NRG1 haplotypes described thus far, and may represent an independent SZ susceptibility locus within NRG1 gene. V266 is a highly conserved residue and its substitution is predicted to have a deleterious effect on the protein. As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls. V266L was found neither in patients nor in controls. Lack of replication of an association across populations may be because of the differences in linkage disequilibrium structure or allele frequencies. Some true associations may not be replicated regardless of the sample size of the study. © 2011 Wolters Kluwer Health. Lippincott Williams & Wilkins.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.comen_HK
dc.relation.ispartofPsychiatric Geneticsen_HK
dc.subjectmutationsen_HK
dc.subjectneuregulin 1en_HK
dc.subjectV266Len_HK
dc.subject.meshAmino Acid Substitution - genetics-
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshNeuregulin-1 - genetics-
dc.subject.meshPolymorphism, Single Nucleotide - genetics-
dc.subject.meshSchizophrenia - genetics-
dc.titleNo NRG1 V266L in Chinese patients with schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0964-6906&volume=21&issue=1&spage=47&epage=49&date=2011&atitle=No+NRG1+V266L+in+Chinese+patients+with+schizophrenia-
dc.identifier.emailGarciaBarceló, MM: mmgarcia@hku.hken_HK
dc.identifier.emailTang, W: evelynt@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailTam, P: paultam@hku.hken_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityGarciaBarceló, MM=rp00445en_HK
dc.identifier.authorityTang, W=rp01629en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authorityTam, P=rp00060en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/YPG.0b013e328341355ben_HK
dc.identifier.pmid20978455en_HK
dc.identifier.scopuseid_2-s2.0-78650772199en_HK
dc.identifier.hkuros189851en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650772199&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue1en_HK
dc.identifier.spage47en_HK
dc.identifier.epage49en_HK
dc.identifier.eissn1473-5873-
dc.identifier.isiWOS:000285544800008-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectDevelopmental genomics and skeletal research-
dc.identifier.scopusauthoridGarciaBarceló, MM=6701767303en_HK
dc.identifier.scopusauthoridMiao, X=7102585391en_HK
dc.identifier.scopusauthoridTang, CS=35764635500en_HK
dc.identifier.scopusauthoridSo, HC=37031934700en_HK
dc.identifier.scopusauthoridTang, W=37462250200en_HK
dc.identifier.scopusauthoridLeon, TYY=10641704600en_HK
dc.identifier.scopusauthoridSo, M=8748542200en_HK
dc.identifier.scopusauthoridYip, B=16685586100en_HK
dc.identifier.scopusauthoridChen, RYL=16635066600en_HK
dc.identifier.scopusauthoridCheung, EFC=7006522469en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK
dc.identifier.scopusauthoridTam, P=7202539421en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK

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