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Article: Commingling analyses of central corneal thickness and adjusted intraocular pressure in an older Australian population

TitleCommingling analyses of central corneal thickness and adjusted intraocular pressure in an older Australian population
Authors
Issue Date2010
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2010, v. 51 n. 5, p. 2512-2518 How to Cite?
AbstractPurpose. To test the hypothesis that there is a major genetic determinant for central corneal thickness (CCT) in a large, population-based sample and to test whether such a determinant accounts for results previously ascribed to intraocular pressure (IOP). Methods. Measurements of IOP and CCT were collected for 1356 individuals, 49 years of age or older, participating in the Blue Mountains Eye Study (third ascertainment call). Linear regression methods were used to adjust CCT for age. IOP was adjusted for CCT. A commingling analysis was performed with a C++ program, SKUDRIVER, to investigate whether the observed CCT and IOP data, adjusted for covariates, were best described by a one-, two-, or three-distribution model. The fitted models were compared by Akaike information criterion (AIC) values. Results. Significant skewness was present in CCT and IOP distributions. The most parsimonious model for age-adjusted CCT was a single-distribution model. For IOP adjusted for CCT the most parsimonious model was a mixture of three distributions with means corresponding to 16.02, 23.36, and 35.59 mm Hg. The proportion of total IOP variance attributable to these distributions was 18.3%. Model parameters were almost identical with those in which IOP was not adjusted for CCT. None of the analyses suggested deviation from Hardy-Weinberg equilibrium. Conclusions. The findings revealed no evidence of a single major genetic determinant for CCT. Previous results suggesting the presence of a major locus for IOP do not appear to be confounded by the influence of CCT on IOP. © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/137514
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
Funding AgencyGrant Number
Special Trustees of Moorfields Eye Hospital
Funding Information:

Supported by Special Trustees of Moorfields Eye Hospital.

References

 

DC FieldValueLanguage
dc.contributor.authorRahman, MLen_HK
dc.contributor.authorBunce, Cen_HK
dc.contributor.authorHealey, PRen_HK
dc.contributor.authorMitchell, Pen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorMcGuffin, Pen_HK
dc.contributor.authorViswanathan, ACen_HK
dc.date.accessioned2011-08-26T14:26:53Z-
dc.date.available2011-08-26T14:26:53Z-
dc.date.issued2010en_HK
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2010, v. 51 n. 5, p. 2512-2518en_HK
dc.identifier.issn0146-0404en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137514-
dc.description.abstractPurpose. To test the hypothesis that there is a major genetic determinant for central corneal thickness (CCT) in a large, population-based sample and to test whether such a determinant accounts for results previously ascribed to intraocular pressure (IOP). Methods. Measurements of IOP and CCT were collected for 1356 individuals, 49 years of age or older, participating in the Blue Mountains Eye Study (third ascertainment call). Linear regression methods were used to adjust CCT for age. IOP was adjusted for CCT. A commingling analysis was performed with a C++ program, SKUDRIVER, to investigate whether the observed CCT and IOP data, adjusted for covariates, were best described by a one-, two-, or three-distribution model. The fitted models were compared by Akaike information criterion (AIC) values. Results. Significant skewness was present in CCT and IOP distributions. The most parsimonious model for age-adjusted CCT was a single-distribution model. For IOP adjusted for CCT the most parsimonious model was a mixture of three distributions with means corresponding to 16.02, 23.36, and 35.59 mm Hg. The proportion of total IOP variance attributable to these distributions was 18.3%. Model parameters were almost identical with those in which IOP was not adjusted for CCT. None of the analyses suggested deviation from Hardy-Weinberg equilibrium. Conclusions. The findings revealed no evidence of a single major genetic determinant for CCT. Previous results suggesting the presence of a major locus for IOP do not appear to be confounded by the influence of CCT on IOP. © Association for Research in Vision and Ophthalmology.en_HK
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_HK
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_HK
dc.subject.meshCornea - pathology-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGlaucoma, Open-Angle - genetics-
dc.subject.meshIntraocular Pressure - genetics-
dc.subject.meshQuantitative Trait Loci-
dc.titleCommingling analyses of central corneal thickness and adjusted intraocular pressure in an older Australian populationen_HK
dc.typeArticleen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1167/iovs.09-4270en_HK
dc.identifier.pmid20071671-
dc.identifier.scopuseid_2-s2.0-77952537175en_HK
dc.identifier.hkuros189818en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952537175&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue5en_HK
dc.identifier.spage2512en_HK
dc.identifier.epage2518en_HK
dc.identifier.isiWOS:000277180500031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRahman, ML=16417663400en_HK
dc.identifier.scopusauthoridBunce, C=7005268305en_HK
dc.identifier.scopusauthoridHealey, PR=7004324793en_HK
dc.identifier.scopusauthoridMitchell, P=7402933815en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_HK
dc.identifier.scopusauthoridViswanathan, AC=7006598235en_HK

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