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Article: Replication study of SNP associations for colorectal cancer in Hong Kong Chinese

TitleReplication study of SNP associations for colorectal cancer in Hong Kong Chinese
Authors
Keywordsassociation
Chinese
colorectal cancer
genetic
replication
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2011, v. 104 n. 2, p. 369-375 How to Cite?
AbstractBackground: Recent genome-wide association studies of colorectal cancer (CRC) have identified common single-nucleotide polymorphisms (SNPs) mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC. Methods: An association study was performed on 892 CRC cases and 890 controls recruited from the Hong Kong Chinese population, genotyping 32 SNPs, which were either associated with CRC in previous studies or are in close proximity to previously reported risk SNPs. Results: Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs10795668 on 10p14, rs4779584 on 15q14 and rs12953717 on 18q21.2. There was significant linear association between CRC risk and the number of independent risk variants possessed by an individual (P2.29 × 10 5). Conclusion: These results indicate that some previously reported SNP associations also impact on CRC risk in the Chinese population. Possible reasons for failure of replication for some loci include inadequate study power, differences in allele frequency, linkage disequilibrium structure or effect size between populations. Our results suggest that many associations for CRC are likely to generalise across populations. © 2011 Cancer Research UK All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/137505
ISSN
2015 Impact Factor: 5.569
2015 SCImago Journal Rankings: 2.939
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Cancer Research UKC1298/A9511
Michael and Betty Kadoorie Cancer Genetic Research Programme II
LKS Faculty of Medicine
Genome Research Centre
The University of Hong Kong
Funding Information:

This work was supported by grants from Cancer Research UK (C1298/A9511) and the Michael and Betty Kadoorie Cancer Genetic Research Programme II. The work also received support from the LKS Faculty of Medicine, the Genome Research Centre and the Genomics Strategic Research Theme of The University of Hong Kong. We are grateful to all individuals who participated in this study.

References

 

DC FieldValueLanguage
dc.contributor.authorHo, JWen_HK
dc.contributor.authorChoi, SCen_HK
dc.contributor.authorLee, YFen_HK
dc.contributor.authorHui, TCen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorGarciaBarceló, MMen_HK
dc.contributor.authorCarvajalCarmona, Len_HK
dc.contributor.authorLiu, Ren_HK
dc.contributor.authorTo, SHen_HK
dc.contributor.authorYau, TKen_HK
dc.contributor.authorChung, CCen_HK
dc.contributor.authorYau, CCen_HK
dc.contributor.authorHui, SMen_HK
dc.contributor.authorLau, PYen_HK
dc.contributor.authorYuen, CHen_HK
dc.contributor.authorWong, YWen_HK
dc.contributor.authorHo, Sen_HK
dc.contributor.authorFung, SSen_HK
dc.contributor.authorTomlinson, IPen_HK
dc.contributor.authorHoulston, RSen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2011-08-26T14:26:45Z-
dc.date.available2011-08-26T14:26:45Z-
dc.date.issued2011en_HK
dc.identifier.citationBritish Journal Of Cancer, 2011, v. 104 n. 2, p. 369-375en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137505-
dc.description.abstractBackground: Recent genome-wide association studies of colorectal cancer (CRC) have identified common single-nucleotide polymorphisms (SNPs) mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC. Methods: An association study was performed on 892 CRC cases and 890 controls recruited from the Hong Kong Chinese population, genotyping 32 SNPs, which were either associated with CRC in previous studies or are in close proximity to previously reported risk SNPs. Results: Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs10795668 on 10p14, rs4779584 on 15q14 and rs12953717 on 18q21.2. There was significant linear association between CRC risk and the number of independent risk variants possessed by an individual (P2.29 × 10 5). Conclusion: These results indicate that some previously reported SNP associations also impact on CRC risk in the Chinese population. Possible reasons for failure of replication for some loci include inadequate study power, differences in allele frequency, linkage disequilibrium structure or effect size between populations. Our results suggest that many associations for CRC are likely to generalise across populations. © 2011 Cancer Research UK All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectassociationen_HK
dc.subjectChineseen_HK
dc.subjectcolorectal canceren_HK
dc.subjectgeneticen_HK
dc.subjectreplicationen_HK
dc.subject.meshCase-Control Studies-
dc.subject.meshColorectal Neoplasms - genetics-
dc.subject.meshHong Kong-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleReplication study of SNP associations for colorectal cancer in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=104&issue=2&spage=369&epage=375&date=2010&atitle=Replication+study+of+SNP+associations+for+colorectal+cancer+in+Hong+Kong+Chineseen_US
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailGarciaBarceló, MM: mmgarcia@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authorityGarciaBarceló, MM=rp00445en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/sj.bjc.6605977en_HK
dc.identifier.pmid21179028-
dc.identifier.pmcidPMC3031883-
dc.identifier.scopuseid_2-s2.0-78751469504en_HK
dc.identifier.hkuros183999en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78751469504&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue2en_HK
dc.identifier.spage369en_HK
dc.identifier.epage375en_HK
dc.identifier.isiWOS:000286370900019-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, JW=55166750600en_HK
dc.identifier.scopusauthoridChoi, SC=54392774100en_HK
dc.identifier.scopusauthoridLee, YF=37037864600en_HK
dc.identifier.scopusauthoridHui, TC=7005618911en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridGarciaBarceló, MM=6701767303en_HK
dc.identifier.scopusauthoridCarvajalCarmona, L=6508060363en_HK
dc.identifier.scopusauthoridLiu, R=15056333400en_HK
dc.identifier.scopusauthoridTo, SH=37038658400en_HK
dc.identifier.scopusauthoridYau, TK=7006540678en_HK
dc.identifier.scopusauthoridChung, CC=7403613635en_HK
dc.identifier.scopusauthoridYau, CC=7007038422en_HK
dc.identifier.scopusauthoridHui, SM=37037531800en_HK
dc.identifier.scopusauthoridLau, PY=11639863300en_HK
dc.identifier.scopusauthoridYuen, CH=36828159600en_HK
dc.identifier.scopusauthoridWong, YW=37038725700en_HK
dc.identifier.scopusauthoridHo, S=12794365900en_HK
dc.identifier.scopusauthoridFung, SS=36678679000en_HK
dc.identifier.scopusauthoridTomlinson, IP=7103338177en_HK
dc.identifier.scopusauthoridHoulston, RS=34569730700en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.citeulike8627416-

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