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Article: Derivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regeneration

TitleDerivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regeneration
Authors
KeywordsMesenchymal stem cells
Schwann cells
Spinal cord injury
Stem cell co-culture
Two-step induction
Issue Date2011
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtcnsnd
Citation
CNS & Neurological Disorders - Drug Targets, 2011, v. 10 n. 4, p. 500-508 How to Cite?
AbstractSchwann cells are critically important for tissue repair, axonal regrowth and remyelination following injury to peripheral nerves. The absence of Schwann cells or an equivalent cell type in the central nervous system (CNS) may limit the regeneration capacity of the CNS. Mesenchymal stem cells (MSCs) have therefore been investigated for their potential to be induced to develop a Schwann cell phenotype. The methods for derivation of Schwann cell-like cells from MSCs and the benefits and limitations of each of these methods are presented in this review. Issues related to instability of the derived Schwann cell phenotype, apoptosis of derived cells in transplants, and the inability to predict with confidence how the cells will behave after transplantation are discussed. Finally, we suggest the need for further elucidation of the biology of Schwann cell differentiation and the signals for their derivation from MSC, in order to resolve these obstacles and to enable transplantation of MSC-derived Schwann cells as a therapeutic strategy in CNS injury. © 2011 Bentham Science Publishers.
Persistent Identifierhttp://hdl.handle.net/10722/137498
ISSN
2015 Impact Factor: 2.188
2015 SCImago Journal Rankings: 0.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCai, Sen_HK
dc.contributor.authorShea, GKHen_HK
dc.contributor.authorTsui, AYPen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorShum, DKYen_HK
dc.date.accessioned2011-08-26T14:26:28Z-
dc.date.available2011-08-26T14:26:28Z-
dc.date.issued2011en_HK
dc.identifier.citationCNS & Neurological Disorders - Drug Targets, 2011, v. 10 n. 4, p. 500-508en_HK
dc.identifier.issn1871-5273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137498-
dc.description.abstractSchwann cells are critically important for tissue repair, axonal regrowth and remyelination following injury to peripheral nerves. The absence of Schwann cells or an equivalent cell type in the central nervous system (CNS) may limit the regeneration capacity of the CNS. Mesenchymal stem cells (MSCs) have therefore been investigated for their potential to be induced to develop a Schwann cell phenotype. The methods for derivation of Schwann cell-like cells from MSCs and the benefits and limitations of each of these methods are presented in this review. Issues related to instability of the derived Schwann cell phenotype, apoptosis of derived cells in transplants, and the inability to predict with confidence how the cells will behave after transplantation are discussed. Finally, we suggest the need for further elucidation of the biology of Schwann cell differentiation and the signals for their derivation from MSC, in order to resolve these obstacles and to enable transplantation of MSC-derived Schwann cells as a therapeutic strategy in CNS injury. © 2011 Bentham Science Publishers.en_HK
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtcnsnden_HK
dc.relation.ispartofCNS & Neurological Disorders - Drug Targetsen_HK
dc.subjectMesenchymal stem cellsen_HK
dc.subjectSchwann cellsen_HK
dc.subjectSpinal cord injuryen_HK
dc.subjectStem cell co-cultureen_HK
dc.subjectTwo-step inductionen_HK
dc.subject.meshBone Marrow Cells - physiologyen_HK
dc.subject.meshCell Differentiation - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMesenchymal Stem Cells - physiologyen_HK
dc.subject.meshNerve Regeneration - physiologyen_HK
dc.subject.meshRegeneration - physiologyen_HK
dc.subject.meshSchwann Cells - physiology - transplantationen_HK
dc.subject.meshStem Cell Transplantation - methodsen_HK
dc.titleDerivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regenerationen_HK
dc.typeArticleen_HK
dc.identifier.emailShea, GKH: gkshea@hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.authorityShea, GKH=rp01781en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/187152711795563930-
dc.identifier.pmid21495967-
dc.identifier.scopuseid_2-s2.0-79956281482en_HK
dc.identifier.hkuros191415en_US
dc.identifier.hkuros234179-
dc.identifier.hkuros253343-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956281482&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue4en_HK
dc.identifier.spage500en_HK
dc.identifier.epage508en_HK
dc.identifier.isiWOS:000291634700009-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridCai, S=21740464700en_HK
dc.identifier.scopusauthoridShea, GKH=36341273600en_HK
dc.identifier.scopusauthoridTsui, AYP=36341669100en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK

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