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Article: Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats
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TitleExtract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats
 
AuthorsChan, E3
Liu, XX3
Guo, DJ3
Kwan, YW4
Leung, GPH1
Lee, SMY2
Chan, SW3
 
KeywordsAntioxidant Activity
Chinese Medicinal Herb
Myocardial Ischemia-Reperfusion Injury
Scutellaria baicalensis Georgi
Total Flavonoid Content
Total Phenol Content
 
Issue Date2011
 
PublisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtml
 
CitationAmerican Journal Of Chinese Medicine, 2011, v. 39 n. 4, p. 693-704 [How to Cite?]
DOI: http://dx.doi.org/10.1142/S0192415X11009135
 
AbstractIschemic heart disease is a major cause of death in the world. Common therapies, such as primary coronary angioplasty and thrombolysis, are applied to restore blood supply to the heart, limit infarct size and reduce mortality. However, the restoration of blood supply would generate reactive oxygen species in damaged sites of the myocardium, intensifying the damage to the cardiac tissues. Radix Scutellariae baicalensis (Huangqin) is a well-known herb in traditional Chinese medicine with high antioxidant power. In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds. The cardioprotective effects of the Sb extracts (3, 30 and 300 mg/kg) were evaluated in myocardial ischemia-reperfusion injuried rats. The results showed that animals that had received five-day pretreatment of the Sb extract (30 mg/kg) had a significant reduction in myocardial infarct size and a marked increase in the activity of catalase in the liver. The Sb extract could additionally enhance acetylcholine-induced vasorelaxation. It was proposed that the Sb extract exerted its cardioprotection by stimulating the catalase activity and improving vascular elasticity. © 2011 World Scientific Publishing Company.
 
ISSN0192-415X
2012 Impact Factor: 2.281
2012 SCImago Journal Rankings: 0.707
 
DOIhttp://dx.doi.org/10.1142/S0192415X11009135
 
ISI Accession Number IDWOS:000292205300006
Funding AgencyGrant Number
Shenzhen Municipal Key Laboratory, Shenzhen, People's Republic of China
Health and Health Services Research Fund, Food and Health Bureau, Hong Kong SAR, People's Republic of China08090471
Funding Information:

This research project was financially supported by the Shenzhen Municipal Key Laboratory Advancement Program, Shenzhen, People's Republic of China, as well as the Health and Health Services Research Fund, Food and Health Bureau, Hong Kong SAR, People's Republic of China (Ref. number: 08090471). Our special thanks are due to Ms. Josephine Hong-Man Leung and Ms. Siu-Hung Tsui for proofreading and providing critical comments on the manuscript.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, E
 
dc.contributor.authorLiu, XX
 
dc.contributor.authorGuo, DJ
 
dc.contributor.authorKwan, YW
 
dc.contributor.authorLeung, GPH
 
dc.contributor.authorLee, SMY
 
dc.contributor.authorChan, SW
 
dc.date.accessioned2011-08-26T14:26:08Z
 
dc.date.available2011-08-26T14:26:08Z
 
dc.date.issued2011
 
dc.description.abstractIschemic heart disease is a major cause of death in the world. Common therapies, such as primary coronary angioplasty and thrombolysis, are applied to restore blood supply to the heart, limit infarct size and reduce mortality. However, the restoration of blood supply would generate reactive oxygen species in damaged sites of the myocardium, intensifying the damage to the cardiac tissues. Radix Scutellariae baicalensis (Huangqin) is a well-known herb in traditional Chinese medicine with high antioxidant power. In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds. The cardioprotective effects of the Sb extracts (3, 30 and 300 mg/kg) were evaluated in myocardial ischemia-reperfusion injuried rats. The results showed that animals that had received five-day pretreatment of the Sb extract (30 mg/kg) had a significant reduction in myocardial infarct size and a marked increase in the activity of catalase in the liver. The Sb extract could additionally enhance acetylcholine-induced vasorelaxation. It was proposed that the Sb extract exerted its cardioprotection by stimulating the catalase activity and improving vascular elasticity. © 2011 World Scientific Publishing Company.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Chinese Medicine, 2011, v. 39 n. 4, p. 693-704 [How to Cite?]
DOI: http://dx.doi.org/10.1142/S0192415X11009135
 
dc.identifier.doihttp://dx.doi.org/10.1142/S0192415X11009135
 
dc.identifier.epage704
 
dc.identifier.hkuros189224
 
dc.identifier.isiWOS:000292205300006
Funding AgencyGrant Number
Shenzhen Municipal Key Laboratory, Shenzhen, People's Republic of China
Health and Health Services Research Fund, Food and Health Bureau, Hong Kong SAR, People's Republic of China08090471
Funding Information:

This research project was financially supported by the Shenzhen Municipal Key Laboratory Advancement Program, Shenzhen, People's Republic of China, as well as the Health and Health Services Research Fund, Food and Health Bureau, Hong Kong SAR, People's Republic of China (Ref. number: 08090471). Our special thanks are due to Ms. Josephine Hong-Man Leung and Ms. Siu-Hung Tsui for proofreading and providing critical comments on the manuscript.

 
dc.identifier.issn0192-415X
2012 Impact Factor: 2.281
2012 SCImago Journal Rankings: 0.707
 
dc.identifier.issue4
 
dc.identifier.pmid21721150
 
dc.identifier.scopuseid_2-s2.0-79959927981
 
dc.identifier.spage693
 
dc.identifier.urihttp://hdl.handle.net/10722/137490
 
dc.identifier.volume39
 
dc.languageeng
 
dc.publisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtml
 
dc.publisher.placeSingapore
 
dc.relation.ispartofAmerican Journal of Chinese Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe American Journal of Chinese Medicine. Copyright © World Scientific Publishing Co Pte Ltd.
 
dc.subject.meshCardiotonic Agents - analysis - pharmacology - therapeutic use
 
dc.subject.meshMyocardial Reperfusion Injury - metabolism - pathology - prevention and control
 
dc.subject.meshPhytotherapy
 
dc.subject.meshPlant Extracts - chemistry - pharmacology - therapeutic use
 
dc.subject.meshPolyphenols - analysis - pharmacology - therapeutic use
 
dc.subjectAntioxidant Activity
 
dc.subjectChinese Medicinal Herb
 
dc.subjectMyocardial Ischemia-Reperfusion Injury
 
dc.subjectScutellaria baicalensis Georgi
 
dc.subjectTotal Flavonoid Content
 
dc.subjectTotal Phenol Content
 
dc.titleExtract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. University of Macau
  3. Hong Kong Polytechnic University
  4. Chinese University of Hong Kong