Article: Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats
| Title | Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Chan, E3 Liu, XX3 Guo, DJ3 Kwan, YW4 Leung, GPH1 Lee, SMY2 Chan, SW3 | ||||||
| Keywords | Antioxidant Activity Chinese Medicinal Herb Myocardial Ischemia-Reperfusion Injury Scutellaria baicalensis Georgi Total Flavonoid Content Total Phenol Content | ||||||
| Issue Date | 2011 | ||||||
| Publisher | World Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtml | ||||||
| Citation | American Journal Of Chinese Medicine, 2011, v. 39 n. 4, p. 693-704 [How to Cite?] DOI: http://dx.doi.org/10.1142/S0192415X11009135 | ||||||
| Abstract | Ischemic heart disease is a major cause of death in the world. Common therapies, such as primary coronary angioplasty and thrombolysis, are applied to restore blood supply to the heart, limit infarct size and reduce mortality. However, the restoration of blood supply would generate reactive oxygen species in damaged sites of the myocardium, intensifying the damage to the cardiac tissues. Radix Scutellariae baicalensis (Huangqin) is a well-known herb in traditional Chinese medicine with high antioxidant power. In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds. The cardioprotective effects of the Sb extracts (3, 30 and 300 mg/kg) were evaluated in myocardial ischemia-reperfusion injuried rats. The results showed that animals that had received five-day pretreatment of the Sb extract (30 mg/kg) had a significant reduction in myocardial infarct size and a marked increase in the activity of catalase in the liver. The Sb extract could additionally enhance acetylcholine-induced vasorelaxation. It was proposed that the Sb extract exerted its cardioprotection by stimulating the catalase activity and improving vascular elasticity. © 2011 World Scientific Publishing Company. | ||||||
| ISSN | 0192-415X 2011 Impact Factor: 1.979 2011 SCImago Journal Rankings: 0.084 | ||||||
| DOI | http://dx.doi.org/10.1142/S0192415X11009135 | ||||||
| ISI Accession Number ID | WOS:000292205300006
Funding Information: This research project was financially supported by the Shenzhen Municipal Key Laboratory Advancement Program, Shenzhen, People's Republic of China, as well as the Health and Health Services Research Fund, Food and Health Bureau, Hong Kong SAR, People's Republic of China (Ref. number: 08090471). Our special thanks are due to Ms. Josephine Hong-Man Leung and Ms. Siu-Hung Tsui for proofreading and providing critical comments on the manuscript. | ||||||
| References | References in Scopus |
| dc.contributor.author | Chan, E | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Liu, XX | ||||||
| dc.contributor.author | Guo, DJ | ||||||
| dc.contributor.author | Kwan, YW | ||||||
| dc.contributor.author | Leung, GPH | ||||||
| dc.contributor.author | Lee, SMY | ||||||
| dc.contributor.author | Chan, SW | ||||||
| dc.date.accessioned | 2011-08-26T14:26:08Z | ||||||
| dc.date.available | 2011-08-26T14:26:08Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Ischemic heart disease is a major cause of death in the world. Common therapies, such as primary coronary angioplasty and thrombolysis, are applied to restore blood supply to the heart, limit infarct size and reduce mortality. However, the restoration of blood supply would generate reactive oxygen species in damaged sites of the myocardium, intensifying the damage to the cardiac tissues. Radix Scutellariae baicalensis (Huangqin) is a well-known herb in traditional Chinese medicine with high antioxidant power. In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds. The cardioprotective effects of the Sb extracts (3, 30 and 300 mg/kg) were evaluated in myocardial ischemia-reperfusion injuried rats. The results showed that animals that had received five-day pretreatment of the Sb extract (30 mg/kg) had a significant reduction in myocardial infarct size and a marked increase in the activity of catalase in the liver. The Sb extract could additionally enhance acetylcholine-induced vasorelaxation. It was proposed that the Sb extract exerted its cardioprotection by stimulating the catalase activity and improving vascular elasticity. © 2011 World Scientific Publishing Company. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | American Journal Of Chinese Medicine, 2011, v. 39 n. 4, p. 693-704 [How to Cite?] DOI: http://dx.doi.org/10.1142/S0192415X11009135 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1142/S0192415X11009135 | ||||||
| dc.identifier.epage | 704 | ||||||
| dc.identifier.hkuros | 189224 | ||||||
| dc.identifier.isi | WOS:000292205300006
Funding Information: This research project was financially supported by the Shenzhen Municipal Key Laboratory Advancement Program, Shenzhen, People's Republic of China, as well as the Health and Health Services Research Fund, Food and Health Bureau, Hong Kong SAR, People's Republic of China (Ref. number: 08090471). Our special thanks are due to Ms. Josephine Hong-Man Leung and Ms. Siu-Hung Tsui for proofreading and providing critical comments on the manuscript. | ||||||
| dc.identifier.issn | 0192-415X 2011 Impact Factor: 1.979 2011 SCImago Journal Rankings: 0.084 | ||||||
| dc.identifier.issue | 4 | ||||||
| dc.identifier.pmid | 21721150 | ||||||
| dc.identifier.scopus | eid_2-s2.0-79959927981 | ||||||
| dc.identifier.spage | 693 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/137490 | ||||||
| dc.identifier.volume | 39 | ||||||
| dc.language | eng | ||||||
| dc.publisher | World Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtml | ||||||
| dc.publisher.place | Singapore | ||||||
| dc.relation.ispartof | American Journal of Chinese Medicine | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | The American Journal of Chinese Medicine. Copyright © World Scientific Publishing Co Pte Ltd. | ||||||
| dc.subject.mesh | Cardiotonic Agents - analysis - pharmacology - therapeutic use | ||||||
| dc.subject.mesh | Myocardial Reperfusion Injury - metabolism - pathology - prevention and control | ||||||
| dc.subject.mesh | Phytotherapy | ||||||
| dc.subject.mesh | Plant Extracts - chemistry - pharmacology - therapeutic use | ||||||
| dc.subject.mesh | Polyphenols - analysis - pharmacology - therapeutic use | ||||||
| dc.subject | Antioxidant Activity | ||||||
| dc.subject | Chinese Medicinal Herb | ||||||
| dc.subject | Myocardial Ischemia-Reperfusion Injury | ||||||
| dc.subject | Scutellaria baicalensis Georgi | ||||||
| dc.subject | Total Flavonoid Content | ||||||
| dc.subject | Total Phenol Content | ||||||
| dc.title | Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- University of Macau
- Hong Kong Polytechnic University
- Chinese University of Hong Kong