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Article: Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats

TitleExtract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats
Authors
KeywordsAntioxidant Activity
Chinese Medicinal Herb
Myocardial Ischemia-Reperfusion Injury
Scutellaria baicalensis Georgi
Total Flavonoid Content
Total Phenol Content
Issue Date2011
PublisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtml
Citation
American Journal Of Chinese Medicine, 2011, v. 39 n. 4, p. 693-704 How to Cite?
Abstract
Ischemic heart disease is a major cause of death in the world. Common therapies, such as primary coronary angioplasty and thrombolysis, are applied to restore blood supply to the heart, limit infarct size and reduce mortality. However, the restoration of blood supply would generate reactive oxygen species in damaged sites of the myocardium, intensifying the damage to the cardiac tissues. Radix Scutellariae baicalensis (Huangqin) is a well-known herb in traditional Chinese medicine with high antioxidant power. In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds. The cardioprotective effects of the Sb extracts (3, 30 and 300 mg/kg) were evaluated in myocardial ischemia-reperfusion injuried rats. The results showed that animals that had received five-day pretreatment of the Sb extract (30 mg/kg) had a significant reduction in myocardial infarct size and a marked increase in the activity of catalase in the liver. The Sb extract could additionally enhance acetylcholine-induced vasorelaxation. It was proposed that the Sb extract exerted its cardioprotection by stimulating the catalase activity and improving vascular elasticity. © 2011 World Scientific Publishing Company.
Persistent Identifierhttp://hdl.handle.net/10722/137490
ISSN
2013 Impact Factor: 2.625
2013 SCImago Journal Rankings: 0.862
ISI Accession Number ID
Funding AgencyGrant Number
Shenzhen Municipal Key Laboratory, Shenzhen, People's Republic of China
Health and Health Services Research Fund, Food and Health Bureau, Hong Kong SAR, People's Republic of China08090471
Funding Information:

This research project was financially supported by the Shenzhen Municipal Key Laboratory Advancement Program, Shenzhen, People's Republic of China, as well as the Health and Health Services Research Fund, Food and Health Bureau, Hong Kong SAR, People's Republic of China (Ref. number: 08090471). Our special thanks are due to Ms. Josephine Hong-Man Leung and Ms. Siu-Hung Tsui for proofreading and providing critical comments on the manuscript.

References

 

Author Affiliations
  1. The University of Hong Kong
  2. University of Macau
  3. Hong Kong Polytechnic University
  4. Chinese University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorChan, Een_HK
dc.contributor.authorLiu, XXen_HK
dc.contributor.authorGuo, DJen_HK
dc.contributor.authorKwan, YWen_HK
dc.contributor.authorLeung, GPHen_HK
dc.contributor.authorLee, SMYen_HK
dc.contributor.authorChan, SWen_HK
dc.date.accessioned2011-08-26T14:26:08Z-
dc.date.available2011-08-26T14:26:08Z-
dc.date.issued2011en_HK
dc.identifier.citationAmerican Journal Of Chinese Medicine, 2011, v. 39 n. 4, p. 693-704en_HK
dc.identifier.issn0192-415Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/137490-
dc.description.abstractIschemic heart disease is a major cause of death in the world. Common therapies, such as primary coronary angioplasty and thrombolysis, are applied to restore blood supply to the heart, limit infarct size and reduce mortality. However, the restoration of blood supply would generate reactive oxygen species in damaged sites of the myocardium, intensifying the damage to the cardiac tissues. Radix Scutellariae baicalensis (Huangqin) is a well-known herb in traditional Chinese medicine with high antioxidant power. In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds. The cardioprotective effects of the Sb extracts (3, 30 and 300 mg/kg) were evaluated in myocardial ischemia-reperfusion injuried rats. The results showed that animals that had received five-day pretreatment of the Sb extract (30 mg/kg) had a significant reduction in myocardial infarct size and a marked increase in the activity of catalase in the liver. The Sb extract could additionally enhance acetylcholine-induced vasorelaxation. It was proposed that the Sb extract exerted its cardioprotection by stimulating the catalase activity and improving vascular elasticity. © 2011 World Scientific Publishing Company.en_HK
dc.languageengen_US
dc.publisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtmlen_HK
dc.relation.ispartofAmerican Journal of Chinese Medicineen_HK
dc.rightsThe American Journal of Chinese Medicine. Copyright © World Scientific Publishing Co Pte Ltd.-
dc.subjectAntioxidant Activityen_HK
dc.subjectChinese Medicinal Herben_HK
dc.subjectMyocardial Ischemia-Reperfusion Injuryen_HK
dc.subjectScutellaria baicalensis Georgien_HK
dc.subjectTotal Flavonoid Contenten_HK
dc.subjectTotal Phenol Contenten_HK
dc.subject.meshCardiotonic Agents - analysis - pharmacology - therapeutic use-
dc.subject.meshMyocardial Reperfusion Injury - metabolism - pathology - prevention and control-
dc.subject.meshPhytotherapy-
dc.subject.meshPlant Extracts - chemistry - pharmacology - therapeutic use-
dc.subject.meshPolyphenols - analysis - pharmacology - therapeutic use-
dc.titleExtract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in ratsen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, GPH: gphleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, GPH=rp00234en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1142/S0192415X11009135en_HK
dc.identifier.pmid21721150en_HK
dc.identifier.scopuseid_2-s2.0-79959927981en_HK
dc.identifier.hkuros189224en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79959927981&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue4en_HK
dc.identifier.spage693en_HK
dc.identifier.epage704en_HK
dc.identifier.isiWOS:000292205300006-
dc.publisher.placeSingaporeen_HK
dc.identifier.scopusauthoridChan, E=36239729300en_HK
dc.identifier.scopusauthoridLiu, XX=44161193300en_HK
dc.identifier.scopusauthoridGuo, DJ=20436287700en_HK
dc.identifier.scopusauthoridKwan, YW=7005662153en_HK
dc.identifier.scopusauthoridLeung, GPH=35963668200en_HK
dc.identifier.scopusauthoridLee, SMY=35233892600en_HK
dc.identifier.scopusauthoridChan, SW=7404255670en_HK

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