File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene

TitleInhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene
Authors
KeywordsCell adhesion molecules
Inflammation
Nf-′B
Resveratrol
Stilbene
Issue Date2011
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567
Citation
Phytotherapy Research, 2011, v. 25 n. 3, p. 451-457 How to Cite?
AbstractResveratrol (RSV) has been shown to have anti-inflammatory activity and to have a protective role against atherosclerosis. Here it is shown, for the first time, that its derivative trans-3,5,4′-trimethoxystilbene (TMS) may be a more potent anti-inflammatory agent than resveratrol.A comparative analysis of the inhibitory activities of related stilbenes, resveratrol, TMS and polydatin (PD), on monocyte adhesion to TNF-α-activated endothelial cells showed TMS to be the most effective, with PD being the least effective. RSV and its analogues inhibited, albeit differentially, the protein and mRNA expression levels of inducible cell adhesion molecules, ICAM-1 and VCAM-1, in cultured endothelial cells. The mechanism of the inhibitory effects of these stilbenes on endothelial cell-monocyte cell adhesion can be attributed mainly to inhibition of NF-κB pathway activation. The results demonstrate that all three investigated stilbene compounds, especially TMS, exhibit a potent inhibitory effect on inflammation-induced cell-cell adhesion, expression of adhesion molecules and activation of the NF-′B pathway. Copyright © 2010 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/137489
ISSN
2015 Impact Factor: 2.694
2015 SCImago Journal Rankings: 0.842
ISI Accession Number ID
Funding AgencyGrant Number
Macau SAR078/2005/A2
045/2007/A3
Research Committee of the University of MacauUL017/09-Y1
Funding Information:

This study was supported by a grant from the Science and Technology Development Fund, Macau SAR (078/2005/A2 and 045/2007/A3) and the Research Committee of the University of Macau (UL017/09-Y1). There is no potential conflict of interest among the authors or between any author and any external party. This work is submitted solely to this journal and all work has been conducted following ethical guidelines of Institute of Chinese Medical Sciences, Macao.

References

 

DC FieldValueLanguage
dc.contributor.authorDeng, YHen_HK
dc.contributor.authorAlex, Den_HK
dc.contributor.authorHuang, HQen_HK
dc.contributor.authorWang, Nen_HK
dc.contributor.authorYu, Nen_HK
dc.contributor.authorWang, YTen_HK
dc.contributor.authorLeung, GPHen_HK
dc.contributor.authorLee, SMYen_HK
dc.date.accessioned2011-08-26T14:26:07Z-
dc.date.available2011-08-26T14:26:07Z-
dc.date.issued2011en_HK
dc.identifier.citationPhytotherapy Research, 2011, v. 25 n. 3, p. 451-457en_HK
dc.identifier.issn0951-418Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/137489-
dc.description.abstractResveratrol (RSV) has been shown to have anti-inflammatory activity and to have a protective role against atherosclerosis. Here it is shown, for the first time, that its derivative trans-3,5,4′-trimethoxystilbene (TMS) may be a more potent anti-inflammatory agent than resveratrol.A comparative analysis of the inhibitory activities of related stilbenes, resveratrol, TMS and polydatin (PD), on monocyte adhesion to TNF-α-activated endothelial cells showed TMS to be the most effective, with PD being the least effective. RSV and its analogues inhibited, albeit differentially, the protein and mRNA expression levels of inducible cell adhesion molecules, ICAM-1 and VCAM-1, in cultured endothelial cells. The mechanism of the inhibitory effects of these stilbenes on endothelial cell-monocyte cell adhesion can be attributed mainly to inhibition of NF-κB pathway activation. The results demonstrate that all three investigated stilbene compounds, especially TMS, exhibit a potent inhibitory effect on inflammation-induced cell-cell adhesion, expression of adhesion molecules and activation of the NF-′B pathway. Copyright © 2010 John Wiley & Sons, Ltd.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567en_HK
dc.relation.ispartofPhytotherapy Researchen_HK
dc.rightsPhytotherapy Research. Copyright © John Wiley & Sons Ltd.-
dc.subjectCell adhesion moleculesen_HK
dc.subjectInflammationen_HK
dc.subjectNf-′Ben_HK
dc.subjectResveratrolen_HK
dc.subjectStilbeneen_HK
dc.subject.meshCell Adhesion - drug effects-
dc.subject.meshIntercellular Adhesion Molecule-1 - metabolism-
dc.subject.meshNF-kappa B - metabolism-
dc.subject.meshStilbenes - pharmacology-
dc.subject.meshVascular Cell Adhesion Molecule-1 - metabolism-
dc.titleInhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbeneen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, GPH: gphleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, GPH=rp00234en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ptr.3279en_HK
dc.identifier.pmid20740479-
dc.identifier.scopuseid_2-s2.0-79952234852en_HK
dc.identifier.hkuros189220en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952234852&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue3en_HK
dc.identifier.spage451en_HK
dc.identifier.epage457en_HK
dc.identifier.isiWOS:000288133000021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridDeng, YH=34869347600en_HK
dc.identifier.scopusauthoridAlex, D=8270038300en_HK
dc.identifier.scopusauthoridHuang, HQ=16042852300en_HK
dc.identifier.scopusauthoridWang, N=7404340835en_HK
dc.identifier.scopusauthoridYu, N=41562421400en_HK
dc.identifier.scopusauthoridWang, YT=23979017200en_HK
dc.identifier.scopusauthoridLeung, GPH=35963668200en_HK
dc.identifier.scopusauthoridLee, SMY=35233892600en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats