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Article: Vincristine can induce regression of vascular malformation in long standing refractory Kasabach Merritt phenomenon

TitleVincristine can induce regression of vascular malformation in long standing refractory Kasabach Merritt phenomenon
Authors
KeywordsHaemangioma
Kasabach merritt phenomenon
Vascular malformation
Vincristine
Issue Date2011
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2011, v. 16 n. 2, p. 121-124 How to Cite?
AbstractVascular lesion with consumptive anaemia and thrombocytopenia (Kasabach Merritt phenomenon, KMphenomenon) is considered to be related to congenital vascular malformation rather than genuine haemangioma. Unlike the classical strawberry haemangioma, patients with KM phenomenon are often resistant to both steroid and interferon treatment, and the vascular malformation does not regress spontaneously. In the past 2 decades, various forms of treatment have been advocated but few with consistent effect. Recently vincristine, a commonly used chemotherapeutic agent with an anti-angiogenesis action, has demonstrated encouraging clinical effect in infants and young children with KM phenomenon with tolerable side effects. Recent data suggested that vincristine could control the vascular malformation in KM phenomenon if used early. However, its efficacy on patients with long-standing, refractory KM phenomenon remains unknown. We reported here a young adolescent girl with long and refractory KM syndrome who responded to weekly vincristine treatment. The thrombocytopenia resolved completely within 12 weeks of treatment and the size of the vascular malformation continued to shrink over a span of 1.5 years. Future study targeted at this group of patients will help to verify its efficacy in this clinical setting.
Persistent Identifierhttp://hdl.handle.net/10722/137482
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorChow, WCen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2011-08-26T14:25:53Z-
dc.date.available2011-08-26T14:25:53Z-
dc.date.issued2011en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2011, v. 16 n. 2, p. 121-124en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137482-
dc.description.abstractVascular lesion with consumptive anaemia and thrombocytopenia (Kasabach Merritt phenomenon, KMphenomenon) is considered to be related to congenital vascular malformation rather than genuine haemangioma. Unlike the classical strawberry haemangioma, patients with KM phenomenon are often resistant to both steroid and interferon treatment, and the vascular malformation does not regress spontaneously. In the past 2 decades, various forms of treatment have been advocated but few with consistent effect. Recently vincristine, a commonly used chemotherapeutic agent with an anti-angiogenesis action, has demonstrated encouraging clinical effect in infants and young children with KM phenomenon with tolerable side effects. Recent data suggested that vincristine could control the vascular malformation in KM phenomenon if used early. However, its efficacy on patients with long-standing, refractory KM phenomenon remains unknown. We reported here a young adolescent girl with long and refractory KM syndrome who responded to weekly vincristine treatment. The thrombocytopenia resolved completely within 12 weeks of treatment and the size of the vascular malformation continued to shrink over a span of 1.5 years. Future study targeted at this group of patients will help to verify its efficacy in this clinical setting.en_HK
dc.languageengen_US
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.rightsDOAJ-
dc.subjectHaemangiomaen_HK
dc.subjectKasabach merritt phenomenonen_HK
dc.subjectVascular malformationen_HK
dc.subjectVincristineen_HK
dc.titleVincristine can induce regression of vascular malformation in long standing refractory Kasabach Merritt phenomenonen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=16&issue=2&spage=121&epage=124&date=2011&atitle=Vincristine+can+induce+regression+of+vascular+malformation+in+long+standing+refractory+Kasabach+Merritt+Phenomenon-
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-79955415642en_HK
dc.identifier.hkuros186673en_US
dc.identifier.hkuros191936en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955415642&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue2en_HK
dc.identifier.spage121en_HK
dc.identifier.epage124en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridChow, WC=14048056000en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK

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