Article: Endometriosis-associated serous borderline tumor and endometrial stromal sarcoma of the Ovary: A report of a rare lesion in an infant

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TitleEndometriosis-associated serous borderline tumor and endometrial stromal sarcoma of the Ovary: A report of a rare lesion in an infant
AuthorsHo, RSL1
Chan, GCF1
Ha, SY1
Ip, PPC1
KeywordsChildren
Endometrial stromal sarcoma
Endometriosis
Infancy
Ovary
Premenarche
Serous borderline
Issue Date2012
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com
CitationInternational Journal Of Gynecological Pathology, 2012, v. 31 n. 1, p. 98-102 [How to Cite?]
DOI: http://dx.doi.org/10.1097/PGP.0b013e31822103ca
AbstractEndometriosis in infancy is most unusual, and associated tumors in this age group are exceptionally rare. We report a case of a serous borderline tumor and endometrial stromal sarcoma arising in an ovarian endometriotic cyst. The patient was an infant of 18 months of age who presented with an incidental abdominal mass. The serum sex hormones were at prepubertal levels. There was no evidence of precocious puberty or any obvious genital anomaly. Intraoperative findings included a solitary solid and multicystic right ovarian mass without evidence of any extraovarian disease. On microscopic examination, the tumor was composed of an intimate mixture of florid papillary and stromal cell proliferation in the wall of an endometriotic cyst. The papillae showed hierarchical branching and had hyalinized and edematous cores with scattered psammoma bodies. The epithelial cells were mildly atypical and mitotically inactive. The underlying endometrial stromal cells were arranged in irregular tongues that permeated the thickened fibrous cyst wall. They were mitotically active and immunoreactive for CD10. There was no evidence of any primitive germ cell tumor. The patient received no adjuvant treatment and had an uneventful postoperative follow-up period of 30 months. To the best of our knowledge, endometriosis associated with this most unusual combination of ovarian tumors has never been reported in an infant. © 2012 International Society of Gynecological Pathologists.
ISSN0277-1691
2011 Impact Factor: 1.453
2011 SCImago Journal Rankings: 0.130
DOIhttp://dx.doi.org/10.1097/PGP.0b013e31822103ca
ISI Accession Number IDWOS:000298146600013
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHo, RSL
dc.contributor.authorChan, GCF
dc.contributor.authorHa, SY
dc.contributor.authorIp, PPC
dc.date.accessioned2011-08-26T14:25:51Z
dc.date.available2011-08-26T14:25:51Z
dc.date.issued2012
dc.description.abstractEndometriosis in infancy is most unusual, and associated tumors in this age group are exceptionally rare. We report a case of a serous borderline tumor and endometrial stromal sarcoma arising in an ovarian endometriotic cyst. The patient was an infant of 18 months of age who presented with an incidental abdominal mass. The serum sex hormones were at prepubertal levels. There was no evidence of precocious puberty or any obvious genital anomaly. Intraoperative findings included a solitary solid and multicystic right ovarian mass without evidence of any extraovarian disease. On microscopic examination, the tumor was composed of an intimate mixture of florid papillary and stromal cell proliferation in the wall of an endometriotic cyst. The papillae showed hierarchical branching and had hyalinized and edematous cores with scattered psammoma bodies. The epithelial cells were mildly atypical and mitotically inactive. The underlying endometrial stromal cells were arranged in irregular tongues that permeated the thickened fibrous cyst wall. They were mitotically active and immunoreactive for CD10. There was no evidence of any primitive germ cell tumor. The patient received no adjuvant treatment and had an uneventful postoperative follow-up period of 30 months. To the best of our knowledge, endometriosis associated with this most unusual combination of ovarian tumors has never been reported in an infant. © 2012 International Society of Gynecological Pathologists.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Gynecological Pathology, 2012, v. 31 n. 1, p. 98-102 [How to Cite?]
DOI: http://dx.doi.org/10.1097/PGP.0b013e31822103ca
dc.identifier.doihttp://dx.doi.org/10.1097/PGP.0b013e31822103ca
dc.identifier.epage102
dc.identifier.hkuros199040
dc.identifier.isiWOS:000298146600013
dc.identifier.issn0277-1691
2011 Impact Factor: 1.453
2011 SCImago Journal Rankings: 0.130
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid22123729
dc.identifier.scopuseid_2-s2.0-84856675481
dc.identifier.spage98
dc.identifier.urihttp://hdl.handle.net/10722/137477
dc.identifier.volume31
dc.languageeng
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com
dc.publisher.placeUnited States
dc.relation.ispartofInternational Journal of Gynecological Pathology
dc.relation.referencesReferences in Scopus
dc.subjectChildren
dc.subjectEndometrial stromal sarcoma
dc.subjectEndometriosis
dc.subjectInfancy
dc.subjectOvary
dc.subjectPremenarche
dc.subjectSerous borderline
dc.titleEndometriosis-associated serous borderline tumor and endometrial stromal sarcoma of the Ovary: A report of a rare lesion in an infant
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong