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Article: Age-related diffusion patterns in human lumbar intervertebral discs: A pilot study in asymptomatic subjects
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TitleAge-related diffusion patterns in human lumbar intervertebral discs: A pilot study in asymptomatic subjects
 
AuthorsZhang, Z2
Chan, Q2 1
Anthony, MP2
Samartzis, D2
Cheung, KMC2
Khong, PL2
Kim, M2
 
KeywordsAge-related degenerative disc change
Diffusion tensor imaging
Histogram analysis
Intervertebral disc
 
Issue Date2012
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mri
 
CitationMagnetic Resonance Imaging, 2012, v. 30 n. 2, p. 181-188 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.mri.2011.09.021
 
AbstractDiffusion tensor imaging (DTI) may provide an accurate noninvasive method of detecting degenerative matrix alterations in human lumbar intervertebral discs (IVDs). This study aimed to investigate age-related degenerative changes in human lumbar IVDs using DTI. Thirty asymptomatic volunteers ranging in age from 25 to 67 years underwent single-shot diffusion weighted echo-planar imaging on a 3 T scanner. DTI-derived metrics including fractional anisotropy (FA) and mean diffusivity (MD) were analyzed by a histogram analysis method. A Mann-Whitney test was used to compare subject groups (young and elderly) with respect to the diffusion measures, and piecewise linear regression was used to characterize the change in each metric as a function of age. We found significant age-related changes in the elderly adult group, with decrease of MD (11%, P<.001) and increase of FA (20%, P<.001). Our results demonstrate that the degenerative-related changes taking place in the IVDs through aging can be quantitatively accessed by DTI-derived metrics, while the morphologic changes are difficult to be identified in conventional T 2-weighted images. Our initial findings suggest that it would be worthwhile to validate the relationship between DTI metrics and the actual degenerative status of IVDs using extracted disc samples and to extend it to studies on patients with degenerative discs in order to further explore the clinical usefulness and relevance of DTI. © 2012 Elsevier Inc.
 
ISSN0730-725X
2013 Impact Factor: 2.022
2013 SCImago Journal Rankings: 0.978
 
DOIhttp://dx.doi.org/10.1016/j.mri.2011.09.021
 
ISI Accession Number IDWOS:000299453200005
Funding AgencyGrant Number
Research Grants Council of Hong Kong
Funding Information:

The authors thank Dr. Florence Mok and Ms. Yu Pei for assisting in radiologic assessment and subject recruitment, respectively. The work was supported by a grant from the General Research Fund sponsored by the Research Grants Council of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhang, Z
 
dc.contributor.authorChan, Q
 
dc.contributor.authorAnthony, MP
 
dc.contributor.authorSamartzis, D
 
dc.contributor.authorCheung, KMC
 
dc.contributor.authorKhong, PL
 
dc.contributor.authorKim, M
 
dc.date.accessioned2011-08-26T14:25:22Z
 
dc.date.available2011-08-26T14:25:22Z
 
dc.date.issued2012
 
dc.description.abstractDiffusion tensor imaging (DTI) may provide an accurate noninvasive method of detecting degenerative matrix alterations in human lumbar intervertebral discs (IVDs). This study aimed to investigate age-related degenerative changes in human lumbar IVDs using DTI. Thirty asymptomatic volunteers ranging in age from 25 to 67 years underwent single-shot diffusion weighted echo-planar imaging on a 3 T scanner. DTI-derived metrics including fractional anisotropy (FA) and mean diffusivity (MD) were analyzed by a histogram analysis method. A Mann-Whitney test was used to compare subject groups (young and elderly) with respect to the diffusion measures, and piecewise linear regression was used to characterize the change in each metric as a function of age. We found significant age-related changes in the elderly adult group, with decrease of MD (11%, P<.001) and increase of FA (20%, P<.001). Our results demonstrate that the degenerative-related changes taking place in the IVDs through aging can be quantitatively accessed by DTI-derived metrics, while the morphologic changes are difficult to be identified in conventional T 2-weighted images. Our initial findings suggest that it would be worthwhile to validate the relationship between DTI metrics and the actual degenerative status of IVDs using extracted disc samples and to extend it to studies on patients with degenerative discs in order to further explore the clinical usefulness and relevance of DTI. © 2012 Elsevier Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationMagnetic Resonance Imaging, 2012, v. 30 n. 2, p. 181-188 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.mri.2011.09.021
 
dc.identifier.citeulike9997417
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.mri.2011.09.021
 
dc.identifier.epage188
 
dc.identifier.hkuros189133
 
dc.identifier.isiWOS:000299453200005
Funding AgencyGrant Number
Research Grants Council of Hong Kong
Funding Information:

The authors thank Dr. Florence Mok and Ms. Yu Pei for assisting in radiologic assessment and subject recruitment, respectively. The work was supported by a grant from the General Research Fund sponsored by the Research Grants Council of Hong Kong.

 
dc.identifier.issn0730-725X
2013 Impact Factor: 2.022
2013 SCImago Journal Rankings: 0.978
 
dc.identifier.issue2
 
dc.identifier.pmid22055854
 
dc.identifier.scopuseid_2-s2.0-84855516184
 
dc.identifier.spage181
 
dc.identifier.urihttp://hdl.handle.net/10722/137450
 
dc.identifier.volume30
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mri
 
dc.publisher.placeUnited States
 
dc.relation.ispartofMagnetic Resonance Imaging
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAging - pathology
 
dc.subject.meshDiffusion Magnetic Resonance Imaging - methods
 
dc.subject.meshIntervertebral Disc - pathology
 
dc.subject.meshLumbar Vertebrae - pathology
 
dc.subject.meshPilot Projects
 
dc.subjectAge-related degenerative disc change
 
dc.subjectDiffusion tensor imaging
 
dc.subjectHistogram analysis
 
dc.subjectIntervertebral disc
 
dc.titleAge-related diffusion patterns in human lumbar intervertebral discs: A pilot study in asymptomatic subjects
 
dc.typeArticle
 
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<contributor.author>Cheung, KMC</contributor.author>
<contributor.author>Khong, PL</contributor.author>
<contributor.author>Kim, M</contributor.author>
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<description.abstract>Diffusion tensor imaging (DTI) may provide an accurate noninvasive method of detecting degenerative matrix alterations in human lumbar intervertebral discs (IVDs). This study aimed to investigate age-related degenerative changes in human lumbar IVDs using DTI. Thirty asymptomatic volunteers ranging in age from 25 to 67 years underwent single-shot diffusion weighted echo-planar imaging on a 3 T scanner. DTI-derived metrics including fractional anisotropy (FA) and mean diffusivity (MD) were analyzed by a histogram analysis method. A Mann-Whitney test was used to compare subject groups (young and elderly) with respect to the diffusion measures, and piecewise linear regression was used to characterize the change in each metric as a function of age. We found significant age-related changes in the elderly adult group, with decrease of MD (11%, P&lt;.001) and increase of FA (20%, P&lt;.001). Our results demonstrate that the degenerative-related changes taking place in the IVDs through aging can be quantitatively accessed by DTI-derived metrics, while the morphologic changes are difficult to be identified in conventional T 2-weighted images. Our initial findings suggest that it would be worthwhile to validate the relationship between DTI metrics and the actual degenerative status of IVDs using extracted disc samples and to extend it to studies on patients with degenerative discs in order to further explore the clinical usefulness and relevance of DTI. &#169; 2012 Elsevier Inc.</description.abstract>
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Author Affiliations
  1. Philips Healthcare
  2. The University of Hong Kong