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Article: Age-related diffusion patterns in human lumbar intervertebral discs: A pilot study in asymptomatic subjects

TitleAge-related diffusion patterns in human lumbar intervertebral discs: A pilot study in asymptomatic subjects
Authors
KeywordsAge-related degenerative disc change
Diffusion tensor imaging
Histogram analysis
Intervertebral disc
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mri
Citation
Magnetic Resonance Imaging, 2012, v. 30 n. 2, p. 181-188 How to Cite?
AbstractDiffusion tensor imaging (DTI) may provide an accurate noninvasive method of detecting degenerative matrix alterations in human lumbar intervertebral discs (IVDs). This study aimed to investigate age-related degenerative changes in human lumbar IVDs using DTI. Thirty asymptomatic volunteers ranging in age from 25 to 67 years underwent single-shot diffusion weighted echo-planar imaging on a 3 T scanner. DTI-derived metrics including fractional anisotropy (FA) and mean diffusivity (MD) were analyzed by a histogram analysis method. A Mann-Whitney test was used to compare subject groups (young and elderly) with respect to the diffusion measures, and piecewise linear regression was used to characterize the change in each metric as a function of age. We found significant age-related changes in the elderly adult group, with decrease of MD (11%, P<.001) and increase of FA (20%, P<.001). Our results demonstrate that the degenerative-related changes taking place in the IVDs through aging can be quantitatively accessed by DTI-derived metrics, while the morphologic changes are difficult to be identified in conventional T 2-weighted images. Our initial findings suggest that it would be worthwhile to validate the relationship between DTI metrics and the actual degenerative status of IVDs using extracted disc samples and to extend it to studies on patients with degenerative discs in order to further explore the clinical usefulness and relevance of DTI. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/137450
ISSN
2014 Impact Factor: 2.090
2014 SCImago Journal Rankings: 0.894
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong Kong
Funding Information:

The authors thank Dr. Florence Mok and Ms. Yu Pei for assisting in radiologic assessment and subject recruitment, respectively. The work was supported by a grant from the General Research Fund sponsored by the Research Grants Council of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorChan, Qen_HK
dc.contributor.authorAnthony, MPen_HK
dc.contributor.authorSamartzis, Den_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorKim, Men_HK
dc.date.accessioned2011-08-26T14:25:22Z-
dc.date.available2011-08-26T14:25:22Z-
dc.date.issued2012en_HK
dc.identifier.citationMagnetic Resonance Imaging, 2012, v. 30 n. 2, p. 181-188en_HK
dc.identifier.issn0730-725Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/137450-
dc.description.abstractDiffusion tensor imaging (DTI) may provide an accurate noninvasive method of detecting degenerative matrix alterations in human lumbar intervertebral discs (IVDs). This study aimed to investigate age-related degenerative changes in human lumbar IVDs using DTI. Thirty asymptomatic volunteers ranging in age from 25 to 67 years underwent single-shot diffusion weighted echo-planar imaging on a 3 T scanner. DTI-derived metrics including fractional anisotropy (FA) and mean diffusivity (MD) were analyzed by a histogram analysis method. A Mann-Whitney test was used to compare subject groups (young and elderly) with respect to the diffusion measures, and piecewise linear regression was used to characterize the change in each metric as a function of age. We found significant age-related changes in the elderly adult group, with decrease of MD (11%, P<.001) and increase of FA (20%, P<.001). Our results demonstrate that the degenerative-related changes taking place in the IVDs through aging can be quantitatively accessed by DTI-derived metrics, while the morphologic changes are difficult to be identified in conventional T 2-weighted images. Our initial findings suggest that it would be worthwhile to validate the relationship between DTI metrics and the actual degenerative status of IVDs using extracted disc samples and to extend it to studies on patients with degenerative discs in order to further explore the clinical usefulness and relevance of DTI. © 2012 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mrien_HK
dc.relation.ispartofMagnetic Resonance Imagingen_HK
dc.subjectAge-related degenerative disc changeen_HK
dc.subjectDiffusion tensor imagingen_HK
dc.subjectHistogram analysisen_HK
dc.subjectIntervertebral discen_HK
dc.subject.meshAging - pathologyen_HK
dc.subject.meshDiffusion Magnetic Resonance Imaging - methodsen_HK
dc.subject.meshIntervertebral Disc - pathologyen_HK
dc.subject.meshLumbar Vertebrae - pathologyen_HK
dc.subject.meshPilot Projectsen_HK
dc.titleAge-related diffusion patterns in human lumbar intervertebral discs: A pilot study in asymptomatic subjectsen_HK
dc.typeArticleen_HK
dc.identifier.emailAnthony, MP: anthonym@hku.hken_HK
dc.identifier.emailSamartzis, D: dspine@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailKim, M: minakim@hku.hken_HK
dc.identifier.authorityAnthony, MP=rp01302en_HK
dc.identifier.authoritySamartzis, D=rp01430en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityKim, M=rp00292en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mri.2011.09.021en_HK
dc.identifier.pmid22055854en_HK
dc.identifier.scopuseid_2-s2.0-84855516184en_HK
dc.identifier.hkuros189133en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855516184&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue2en_HK
dc.identifier.spage181en_HK
dc.identifier.epage188en_HK
dc.identifier.isiWOS:000299453200005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, Z=53364835700en_HK
dc.identifier.scopusauthoridChan, Q=6602497305en_HK
dc.identifier.scopusauthoridAnthony, MP=35270974300en_HK
dc.identifier.scopusauthoridSamartzis, D=34572771100en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridKim, M=8146283400en_HK
dc.identifier.citeulike9997417-

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