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Article: Type 1 responses of human Vγ9Vδ2 T cells to influenza A viruses

TitleType 1 responses of human Vγ9Vδ2 T cells to influenza A viruses
Authors
Issue Date2011
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2011, v. 85 n. 19, p. 10109-10116 How to Cite?
Abstractγδ T cells are essential constituents of antimicrobial and antitumor defenses. We have recently reported that phosphoantigen isopentenyl pyrophosphate (IPP)-expanded human Vγ9Vδ2 T cells participated in antiinfluenza virus immunity by efficiently killing both human and avian influenza virus-infected monocyte-derived macrophages (MDMs) in vitro. However, little is known about the noncytolytic responses and trafficking program of γδ T cells to influenza virus. In this study, we found that Vγ9Vδ2 T cells expressed both type 1 cytokines and chemokine receptors during influenza virus infection, and IPP-expanded cells had a higher capacity to produce gamma interferon (IFN-γ). Besides their potent cytolytic activity against pandemic H1N1 virus-infected cells, IPP-activated γδ T cells also had noncytolytic inhibitory effects on seasonal and pandemic H1N1 viruses via IFN-γ but had no such effects on avian H5N1 or H9N2 virus. Avian H5N1 and H9N2 viruses induced significantly higher CCL3, CCL4, and CCL5 production in Vγ9Vδ2 T cells than human seasonal H1N1 virus. CCR5 mediated the migration of Vγ9Vδ2 T cells toward influenza virus-infected cells. Our findings suggest a novel therapeutic strategy of using phosphoantigens to boost the antiviral activities of human Vγ9Vδ2 T cells against influenza virus infection. © 2011, American Society for Microbiology.
Persistent Identifierhttp://hdl.handle.net/10722/137432
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Area of Excellence program on influenza
University Grants Committee of the Hong Kong SAR, ChinaAoE/M-12/06
Research Grants Council of Hong KongHKU 777108 M
HKU777407
HKU768108
NSFC, China30973235
Research Fund for the Control of Infectious Diseases, Hong Kong governmentHK-09-03-05
Funding Information:

This work was supported in part by the Area of Excellence program on influenza supported by the University Grants Committee of the Hong Kong SAR, China (project number AoE/M-12/06; to J.S.M.P., Y.-L.L., and W.T.); the General Research Fund, Research Grants Council of Hong Kong (HKU 777108 M, HKU777407, and HKU768108; to W.T. and Y.-L.L.); NSFC, China (30973235; to H.L. and W.T.); and the Research Fund for the Control of Infectious Diseases, Hong Kong government (HK-09-03-05).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorQin, Gen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorZheng, Jen_HK
dc.contributor.authorNg, IHYen_HK
dc.contributor.authorXiang, Zen_HK
dc.contributor.authorLam, KTen_HK
dc.contributor.authorMao, Hen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorMalik Peiris, JSen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorTu, Wen_HK
dc.date.accessioned2011-08-26T14:24:52Z-
dc.date.available2011-08-26T14:24:52Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Virology, 2011, v. 85 n. 19, p. 10109-10116en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/137432-
dc.description.abstractγδ T cells are essential constituents of antimicrobial and antitumor defenses. We have recently reported that phosphoantigen isopentenyl pyrophosphate (IPP)-expanded human Vγ9Vδ2 T cells participated in antiinfluenza virus immunity by efficiently killing both human and avian influenza virus-infected monocyte-derived macrophages (MDMs) in vitro. However, little is known about the noncytolytic responses and trafficking program of γδ T cells to influenza virus. In this study, we found that Vγ9Vδ2 T cells expressed both type 1 cytokines and chemokine receptors during influenza virus infection, and IPP-expanded cells had a higher capacity to produce gamma interferon (IFN-γ). Besides their potent cytolytic activity against pandemic H1N1 virus-infected cells, IPP-activated γδ T cells also had noncytolytic inhibitory effects on seasonal and pandemic H1N1 viruses via IFN-γ but had no such effects on avian H5N1 or H9N2 virus. Avian H5N1 and H9N2 viruses induced significantly higher CCL3, CCL4, and CCL5 production in Vγ9Vδ2 T cells than human seasonal H1N1 virus. CCR5 mediated the migration of Vγ9Vδ2 T cells toward influenza virus-infected cells. Our findings suggest a novel therapeutic strategy of using phosphoantigens to boost the antiviral activities of human Vγ9Vδ2 T cells against influenza virus infection. © 2011, American Society for Microbiology.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.rightsCopyright © American Society for Microbiology, [Journal of Virology, volume 85, page 10109-10116, and 2011]-
dc.titleType 1 responses of human Vγ9Vδ2 T cells to influenza A virusesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=85&issue=19&spage=10109&epage=10116&date=2011&atitle=Type+1+responses+of+human+Vgamma9Vdelta2+T+cells+to+influenza+A+viruses-
dc.identifier.emailLiu, Y: yinpingl@hku.hken_HK
dc.identifier.emailMao, H: hwmau@hku.hken_HK
dc.identifier.emailMalik Peiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailTu, W: wwtu@hku.hken_HK
dc.identifier.authorityLiu, Y=rp00269en_HK
dc.identifier.authorityMao, H=rp01595en_HK
dc.identifier.authorityMalik Peiris, JS=rp00410en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityTu, W=rp00416en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1128/JVI.05341-11en_HK
dc.identifier.pmid21752902-
dc.identifier.pmcidPMC3196408-
dc.identifier.scopuseid_2-s2.0-80053973676en_HK
dc.identifier.hkuros191481en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053973676&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume85en_HK
dc.identifier.issue19en_HK
dc.identifier.spage10109en_HK
dc.identifier.epage10116en_HK
dc.identifier.isiWOS:000296253900043-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridQin, G=35085420900en_HK
dc.identifier.scopusauthoridLiu, Y=35240639600en_HK
dc.identifier.scopusauthoridZheng, J=55217878700en_HK
dc.identifier.scopusauthoridNg, IHY=8671050800en_HK
dc.identifier.scopusauthoridXiang, Z=37032263900en_HK
dc.identifier.scopusauthoridLam, KT=25630903400en_HK
dc.identifier.scopusauthoridMao, H=25632489000en_HK
dc.identifier.scopusauthoridLi, H=54389552100en_HK
dc.identifier.scopusauthoridMalik Peiris, JS=7005486823en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridTu, W=7006479236en_HK

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