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Article: DNA methylation of tumor suppressor miRNA genes: A lesson from the miR-34 family

TitleDNA methylation of tumor suppressor miRNA genes: A lesson from the miR-34 family
Authors
Keywordscancer
DNA methylation
microRNA
miR-34
tumor suppressor
Issue Date2011
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/page/epiteaser
Citation
Epigenomics, 2011, v. 3 n. 1, p. 83-92 How to Cite?
AbstractmiRNA is a small ncRNA of 22-25 nucleotides, which leads to mRNA degradation or translational inhibition of its target genes. miRNAs are involved in multiple cellular processes, including cellular differentiation, proliferation and apoptosis, and hence miRNA deregulation has been implicated in disease states, including cancer. On the other hand, DNA methylation leads to gene silencing, and serves as an alternative mechanism of gene inactivation. The aberrant DNA methylation of gene promoters has been shown to result in the inactivation of tumor suppressor genes, and therefore is also implicated in carcinogenesis. This article focuses on the role of miRNA methylation, in particular miR-34a, in cancer. The article begins with an overview of DNA methylation in normal and cancer cells and deregulation of miRNA expression by DNA methylation. These discussions are followed by a description of the gene structure of the miR-34 family of miRNA genes, the tumor suppressor role of miR-34a and the deregulation of miR-34a by DNA methylation in both epithelial and hematological cancers. Moreover, the methylation of miR-34b/c in cancer is also described. Finally, the potential role of miRNA methylation as a biomarker for diagnosis, prognosis (and hence the potential of developing a risk-stratified approach) and a therapeutic target is discussed. © 2011 Future Medicine Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/137371
ISSN
2015 Impact Factor: 4.044
2015 SCImago Journal Rankings: 1.705
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KYen_HK
dc.contributor.authorYu, Len_HK
dc.contributor.authorChim, CSen_HK
dc.date.accessioned2011-08-26T14:24:03Z-
dc.date.available2011-08-26T14:24:03Z-
dc.date.issued2011en_HK
dc.identifier.citationEpigenomics, 2011, v. 3 n. 1, p. 83-92en_HK
dc.identifier.issn1750-1911en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137371-
dc.description.abstractmiRNA is a small ncRNA of 22-25 nucleotides, which leads to mRNA degradation or translational inhibition of its target genes. miRNAs are involved in multiple cellular processes, including cellular differentiation, proliferation and apoptosis, and hence miRNA deregulation has been implicated in disease states, including cancer. On the other hand, DNA methylation leads to gene silencing, and serves as an alternative mechanism of gene inactivation. The aberrant DNA methylation of gene promoters has been shown to result in the inactivation of tumor suppressor genes, and therefore is also implicated in carcinogenesis. This article focuses on the role of miRNA methylation, in particular miR-34a, in cancer. The article begins with an overview of DNA methylation in normal and cancer cells and deregulation of miRNA expression by DNA methylation. These discussions are followed by a description of the gene structure of the miR-34 family of miRNA genes, the tumor suppressor role of miR-34a and the deregulation of miR-34a by DNA methylation in both epithelial and hematological cancers. Moreover, the methylation of miR-34b/c in cancer is also described. Finally, the potential role of miRNA methylation as a biomarker for diagnosis, prognosis (and hence the potential of developing a risk-stratified approach) and a therapeutic target is discussed. © 2011 Future Medicine Ltd.en_HK
dc.languageengen_US
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/page/epiteaseren_HK
dc.relation.ispartofEpigenomicsen_HK
dc.subjectcanceren_HK
dc.subjectDNA methylationen_HK
dc.subjectmicroRNAen_HK
dc.subjectmiR-34en_HK
dc.subjecttumor suppressoren_HK
dc.subject.meshDNA Methylation - physiology-
dc.subject.meshGenes, Tumor Suppressor - physiology-
dc.subject.meshMicroRNAs - genetics - metabolism - physiology-
dc.subject.meshMultigene Family - genetics - physiology-
dc.subject.meshNeoplasms - physiopathology-
dc.titleDNA methylation of tumor suppressor miRNA genes: A lesson from the miR-34 familyen_HK
dc.typeArticleen_HK
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2217/epi.10.74en_HK
dc.identifier.pmid22126155-
dc.identifier.scopuseid_2-s2.0-79951938163en_HK
dc.identifier.hkuros189641en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79951938163&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue1en_HK
dc.identifier.spage83en_HK
dc.identifier.epage92en_HK
dc.identifier.isiWOS:000288841100011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, KY=36151671200en_HK
dc.identifier.scopusauthoridYu, L=7404163935en_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK

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