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Article: In vitro biological evaluation of fibrous PHBV polymer and CHA/PHBV nanocomposite scaffolds developed for tissue engineering applications

TitleIn vitro biological evaluation of fibrous PHBV polymer and CHA/PHBV nanocomposite scaffolds developed for tissue engineering applications
Authors
KeywordsCarbonated hydroxyapatite (CHA)
Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)
Electrospinning
Nanocomposite
Scaffold
Issue Date2011
PublisherAshdin Publishing. The Journal's web site is located at http://www.ashdin.com/journals/bda/bda.aspx
Citation
Bioceramics Development and Applications, 2011, v. 1, article no. D110168 How to Cite?
AbstractIn recent years, a variety of fibrous bioactive bioceramic-polymer composite scaffolds were made through electrospinning and their usefulness for bone tissue engineering was investigated. In this study, nanospheres of carbonated hydroxyapatite (CHA), which is a proven osteoconductive and biodegradable bioceramic, were synthesized using a nanoemulsion process and relatively high amounts of CHA nanospheres were successfully incorporated into electrospun poly(hydroxybutyrate-cohydroxyvalerate) (PHBV) fibers with the aid of an ultrasonic power source. The biological evaluation of electrospun fibrous PHBV scaffolds and CHA/PHBV nanocomposite scaffolds were conducted through in vitro cell culture using the human osteoblast cell-line SaOS-2. Although both types of scaffolds supported the proliferation and spreading of SaOS-2 cells, the CHA/PHBV scaffolds caused significantly higher expression of alkaline phosphatase (ALP) activity of SaOS-2 cells than the PHBV scaffolds after 14 days of cell culture, indicating the potential of fibrous CHA/PHBV nanocomposite scaffolds for bone tissue regeneration applications.
Persistent Identifierhttp://hdl.handle.net/10722/137339
ISSN

 

DC FieldValueLanguage
dc.contributor.authorTong, HWen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorLu, WWen_US
dc.date.accessioned2011-08-26T14:23:29Z-
dc.date.available2011-08-26T14:23:29Z-
dc.date.issued2011en_US
dc.identifier.citationBioceramics Development and Applications, 2011, v. 1, article no. D110168en_US
dc.identifier.issn2090-5017-
dc.identifier.urihttp://hdl.handle.net/10722/137339-
dc.description.abstractIn recent years, a variety of fibrous bioactive bioceramic-polymer composite scaffolds were made through electrospinning and their usefulness for bone tissue engineering was investigated. In this study, nanospheres of carbonated hydroxyapatite (CHA), which is a proven osteoconductive and biodegradable bioceramic, were synthesized using a nanoemulsion process and relatively high amounts of CHA nanospheres were successfully incorporated into electrospun poly(hydroxybutyrate-cohydroxyvalerate) (PHBV) fibers with the aid of an ultrasonic power source. The biological evaluation of electrospun fibrous PHBV scaffolds and CHA/PHBV nanocomposite scaffolds were conducted through in vitro cell culture using the human osteoblast cell-line SaOS-2. Although both types of scaffolds supported the proliferation and spreading of SaOS-2 cells, the CHA/PHBV scaffolds caused significantly higher expression of alkaline phosphatase (ALP) activity of SaOS-2 cells than the PHBV scaffolds after 14 days of cell culture, indicating the potential of fibrous CHA/PHBV nanocomposite scaffolds for bone tissue regeneration applications.-
dc.languageengen_US
dc.publisherAshdin Publishing. The Journal's web site is located at http://www.ashdin.com/journals/bda/bda.aspx-
dc.relation.ispartofBioceramics Development and Applicationsen_US
dc.subjectCarbonated hydroxyapatite (CHA)-
dc.subjectPoly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)-
dc.subjectElectrospinning-
dc.subjectNanocomposite-
dc.subjectScaffold-
dc.titleIn vitro biological evaluation of fibrous PHBV polymer and CHA/PHBV nanocomposite scaffolds developed for tissue engineering applicationsen_US
dc.typeArticleen_US
dc.identifier.emailTong, HW: meboris@hku.hken_US
dc.identifier.emailWang, M: memwang@hkucc.hku.hken_US
dc.identifier.emailLu, WW: wwlu@hku.hken_US
dc.identifier.authorityWang, M=rp00185en_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.4303/bda/D110168-
dc.identifier.hkuros189911en_US
dc.identifier.volume1en_US
dc.publisher.placeUnited States-

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