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Article: Electrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: Effects of electrospinning parameters and solution properties

TitleElectrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: Effects of electrospinning parameters and solution properties
Authors
Keywordselectrospinning
microfibers
nanofibers
PHBV
poly(hydroxybutyrate-co- hydroxyvalerate)
tissue engineering scaffold
Issue Date2011
PublisherTaylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00222348.asp
Citation
Journal Of Macromolecular Science, Part B: Physics, 2011, v. 50 n. 8, p. 1535-1558 How to Cite?
AbstractElectrospinning, a technology capable of fabricating ultrafine fibers (microfibers and nanofibers), has been investigated by various research groups for the production of fibrous biopolymer membranes for potential medical applications. In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a natural, biocompatible, and biodegradable polymer, was successfully electrospun to form nonwoven fibrous mats. The effects of different electrospinning parameters (solution feeding rate, applied voltage, working distance and needle size) and polymer solution properties (concentration, viscosity and conductivity) on fiber diameter and morphology were systematically studied and causes for these effects are discussed. The formation of beaded fibers was investigated and the mechanism presented. It was shown that by varying electrospinning parameters within the processing window that was determined in this study, the diameter of electrospun PHBV fibers could be adjusted from a few hundred nanometers to a few microns, which are in the desirable range for constructing biomimicking fibrous scaffolds for tissue engineering applications. Copyright © Taylor & Francis Group, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/137335
ISSN
2014 Impact Factor: 0.740
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong (HKU)
Research Grants Council of Hong KongHKU 7176/08E
HKU
Funding Information:

This work was supported by a research grant for the Bio-nanotechnology Research Theme from The University of Hong Kong (HKU) and also by a GRF grant (HKU 7176/08E) from the Research Grants Council of Hong Kong. H.-W. Tong thanks HKU for providing him with a research studentship. The authors acknowledge the assistance provided by technical staff in the Department of Mechanical Engineering, HKU.

References

 

DC FieldValueLanguage
dc.contributor.authorTong, HWen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2011-08-26T14:23:27Z-
dc.date.available2011-08-26T14:23:27Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Macromolecular Science, Part B: Physics, 2011, v. 50 n. 8, p. 1535-1558en_HK
dc.identifier.issn0022-2348en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137335-
dc.description.abstractElectrospinning, a technology capable of fabricating ultrafine fibers (microfibers and nanofibers), has been investigated by various research groups for the production of fibrous biopolymer membranes for potential medical applications. In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a natural, biocompatible, and biodegradable polymer, was successfully electrospun to form nonwoven fibrous mats. The effects of different electrospinning parameters (solution feeding rate, applied voltage, working distance and needle size) and polymer solution properties (concentration, viscosity and conductivity) on fiber diameter and morphology were systematically studied and causes for these effects are discussed. The formation of beaded fibers was investigated and the mechanism presented. It was shown that by varying electrospinning parameters within the processing window that was determined in this study, the diameter of electrospun PHBV fibers could be adjusted from a few hundred nanometers to a few microns, which are in the desirable range for constructing biomimicking fibrous scaffolds for tissue engineering applications. Copyright © Taylor & Francis Group, LLC.en_HK
dc.languageengen_US
dc.publisherTaylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00222348.aspen_HK
dc.relation.ispartofJournal of Macromolecular Science, Part B: Physicsen_HK
dc.subjectelectrospinningen_HK
dc.subjectmicrofibersen_HK
dc.subjectnanofibersen_HK
dc.subjectPHBVen_HK
dc.subjectpoly(hydroxybutyrate-co- hydroxyvalerate)en_HK
dc.subjecttissue engineering scaffolden_HK
dc.titleElectrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: Effects of electrospinning parameters and solution propertiesen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/00222348.2010.541008en_HK
dc.identifier.scopuseid_2-s2.0-79960661793en_HK
dc.identifier.hkuros189907en_US
dc.identifier.hkuros207445-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960661793&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1535en_HK
dc.identifier.epage1558en_HK
dc.identifier.isiWOS:000297729100007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTong, HW=23476100900en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK

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