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Article: Electrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: Effects of electrospinning parameters and solution properties
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TitleElectrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: Effects of electrospinning parameters and solution properties
 
AuthorsTong, HW1
Wang, M1
 
Keywordselectrospinning
microfibers
nanofibers
PHBV
poly(hydroxybutyrate-co- hydroxyvalerate)
tissue engineering scaffold
 
Issue Date2011
 
PublisherTaylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00222348.asp
 
CitationJournal Of Macromolecular Science, Part B: Physics, 2011, v. 50 n. 8, p. 1535-1558 [How to Cite?]
DOI: http://dx.doi.org/10.1080/00222348.2010.541008
 
AbstractElectrospinning, a technology capable of fabricating ultrafine fibers (microfibers and nanofibers), has been investigated by various research groups for the production of fibrous biopolymer membranes for potential medical applications. In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a natural, biocompatible, and biodegradable polymer, was successfully electrospun to form nonwoven fibrous mats. The effects of different electrospinning parameters (solution feeding rate, applied voltage, working distance and needle size) and polymer solution properties (concentration, viscosity and conductivity) on fiber diameter and morphology were systematically studied and causes for these effects are discussed. The formation of beaded fibers was investigated and the mechanism presented. It was shown that by varying electrospinning parameters within the processing window that was determined in this study, the diameter of electrospun PHBV fibers could be adjusted from a few hundred nanometers to a few microns, which are in the desirable range for constructing biomimicking fibrous scaffolds for tissue engineering applications. Copyright © Taylor & Francis Group, LLC.
 
ISSN0022-2348
2013 Impact Factor: 0.619
 
DOIhttp://dx.doi.org/10.1080/00222348.2010.541008
 
ISI Accession Number IDWOS:000297729100007
Funding AgencyGrant Number
University of Hong Kong (HKU)
Research Grants Council of Hong KongHKU 7176/08E
HKU
Funding Information:

This work was supported by a research grant for the Bio-nanotechnology Research Theme from The University of Hong Kong (HKU) and also by a GRF grant (HKU 7176/08E) from the Research Grants Council of Hong Kong. H.-W. Tong thanks HKU for providing him with a research studentship. The authors acknowledge the assistance provided by technical staff in the Department of Mechanical Engineering, HKU.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTong, HW
 
dc.contributor.authorWang, M
 
dc.date.accessioned2011-08-26T14:23:27Z
 
dc.date.available2011-08-26T14:23:27Z
 
dc.date.issued2011
 
dc.description.abstractElectrospinning, a technology capable of fabricating ultrafine fibers (microfibers and nanofibers), has been investigated by various research groups for the production of fibrous biopolymer membranes for potential medical applications. In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a natural, biocompatible, and biodegradable polymer, was successfully electrospun to form nonwoven fibrous mats. The effects of different electrospinning parameters (solution feeding rate, applied voltage, working distance and needle size) and polymer solution properties (concentration, viscosity and conductivity) on fiber diameter and morphology were systematically studied and causes for these effects are discussed. The formation of beaded fibers was investigated and the mechanism presented. It was shown that by varying electrospinning parameters within the processing window that was determined in this study, the diameter of electrospun PHBV fibers could be adjusted from a few hundred nanometers to a few microns, which are in the desirable range for constructing biomimicking fibrous scaffolds for tissue engineering applications. Copyright © Taylor & Francis Group, LLC.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Macromolecular Science, Part B: Physics, 2011, v. 50 n. 8, p. 1535-1558 [How to Cite?]
DOI: http://dx.doi.org/10.1080/00222348.2010.541008
 
dc.identifier.doihttp://dx.doi.org/10.1080/00222348.2010.541008
 
dc.identifier.epage1558
 
dc.identifier.hkuros189907
 
dc.identifier.hkuros207445
 
dc.identifier.isiWOS:000297729100007
Funding AgencyGrant Number
University of Hong Kong (HKU)
Research Grants Council of Hong KongHKU 7176/08E
HKU
Funding Information:

This work was supported by a research grant for the Bio-nanotechnology Research Theme from The University of Hong Kong (HKU) and also by a GRF grant (HKU 7176/08E) from the Research Grants Council of Hong Kong. H.-W. Tong thanks HKU for providing him with a research studentship. The authors acknowledge the assistance provided by technical staff in the Department of Mechanical Engineering, HKU.

 
dc.identifier.issn0022-2348
2013 Impact Factor: 0.619
 
dc.identifier.issue8
 
dc.identifier.scopuseid_2-s2.0-79960661793
 
dc.identifier.spage1535
 
dc.identifier.urihttp://hdl.handle.net/10722/137335
 
dc.identifier.volume50
 
dc.languageeng
 
dc.publisherTaylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00222348.asp
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Macromolecular Science, Part B: Physics
 
dc.relation.referencesReferences in Scopus
 
dc.subjectelectrospinning
 
dc.subjectmicrofibers
 
dc.subjectnanofibers
 
dc.subjectPHBV
 
dc.subjectpoly(hydroxybutyrate-co- hydroxyvalerate)
 
dc.subjecttissue engineering scaffold
 
dc.titleElectrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: Effects of electrospinning parameters and solution properties
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong