Article: Electrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: Effects of electrospinning parameters and solution properties

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TitleElectrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: Effects of electrospinning parameters and solution properties
AuthorsTong, HW1
Wang, M1
Keywordselectrospinning
microfibers
nanofibers
PHBV
poly(hydroxybutyrate-co- hydroxyvalerate)
tissue engineering scaffold
Issue Date2011
PublisherTaylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00222348.asp
CitationJournal Of Macromolecular Science, Part B: Physics, 2011, v. 50 n. 8, p. 1535-1558 [How to Cite?]
DOI: http://dx.doi.org/10.1080/00222348.2010.541008
AbstractElectrospinning, a technology capable of fabricating ultrafine fibers (microfibers and nanofibers), has been investigated by various research groups for the production of fibrous biopolymer membranes for potential medical applications. In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a natural, biocompatible, and biodegradable polymer, was successfully electrospun to form nonwoven fibrous mats. The effects of different electrospinning parameters (solution feeding rate, applied voltage, working distance and needle size) and polymer solution properties (concentration, viscosity and conductivity) on fiber diameter and morphology were systematically studied and causes for these effects are discussed. The formation of beaded fibers was investigated and the mechanism presented. It was shown that by varying electrospinning parameters within the processing window that was determined in this study, the diameter of electrospun PHBV fibers could be adjusted from a few hundred nanometers to a few microns, which are in the desirable range for constructing biomimicking fibrous scaffolds for tissue engineering applications. Copyright © Taylor & Francis Group, LLC.
ISSN0022-2348
2011 Impact Factor: 0.739
2011 SCImago Journal Rankings: 0.050
DOIhttp://dx.doi.org/10.1080/00222348.2010.541008
ISI Accession Number IDWOS:000297729100007
Funding AgencyGrant Number
University of Hong Kong (HKU)
Research Grants Council of Hong KongHKU 7176/08E
HKU
Funding Information:

This work was supported by a research grant for the Bio-nanotechnology Research Theme from The University of Hong Kong (HKU) and also by a GRF grant (HKU 7176/08E) from the Research Grants Council of Hong Kong. H.-W. Tong thanks HKU for providing him with a research studentship. The authors acknowledge the assistance provided by technical staff in the Department of Mechanical Engineering, HKU.

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTong, HW
dc.contributor.authorWang, M
dc.date.accessioned2011-08-26T14:23:27Z
dc.date.available2011-08-26T14:23:27Z
dc.date.issued2011
dc.description.abstractElectrospinning, a technology capable of fabricating ultrafine fibers (microfibers and nanofibers), has been investigated by various research groups for the production of fibrous biopolymer membranes for potential medical applications. In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a natural, biocompatible, and biodegradable polymer, was successfully electrospun to form nonwoven fibrous mats. The effects of different electrospinning parameters (solution feeding rate, applied voltage, working distance and needle size) and polymer solution properties (concentration, viscosity and conductivity) on fiber diameter and morphology were systematically studied and causes for these effects are discussed. The formation of beaded fibers was investigated and the mechanism presented. It was shown that by varying electrospinning parameters within the processing window that was determined in this study, the diameter of electrospun PHBV fibers could be adjusted from a few hundred nanometers to a few microns, which are in the desirable range for constructing biomimicking fibrous scaffolds for tissue engineering applications. Copyright © Taylor & Francis Group, LLC.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Macromolecular Science, Part B: Physics, 2011, v. 50 n. 8, p. 1535-1558 [How to Cite?]
DOI: http://dx.doi.org/10.1080/00222348.2010.541008
dc.identifier.doihttp://dx.doi.org/10.1080/00222348.2010.541008
dc.identifier.epage1558
dc.identifier.hkuros189907
dc.identifier.hkuros207445
dc.identifier.isiWOS:000297729100007
Funding AgencyGrant Number
University of Hong Kong (HKU)
Research Grants Council of Hong KongHKU 7176/08E
HKU
Funding Information:

This work was supported by a research grant for the Bio-nanotechnology Research Theme from The University of Hong Kong (HKU) and also by a GRF grant (HKU 7176/08E) from the Research Grants Council of Hong Kong. H.-W. Tong thanks HKU for providing him with a research studentship. The authors acknowledge the assistance provided by technical staff in the Department of Mechanical Engineering, HKU.

dc.identifier.issn0022-2348
2011 Impact Factor: 0.739
2011 SCImago Journal Rankings: 0.050
dc.identifier.issue8
dc.identifier.scopuseid_2-s2.0-79960661793
dc.identifier.spage1535
dc.identifier.urihttp://hdl.handle.net/10722/137335
dc.identifier.volume50
dc.languageeng
dc.publisherTaylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00222348.asp
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Macromolecular Science, Part B: Physics
dc.relation.referencesReferences in Scopus
dc.subjectelectrospinning
dc.subjectmicrofibers
dc.subjectnanofibers
dc.subjectPHBV
dc.subjectpoly(hydroxybutyrate-co- hydroxyvalerate)
dc.subjecttissue engineering scaffold
dc.titleElectrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: Effects of electrospinning parameters and solution properties
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong