Article: An investigation into the influence of electrospinning parameters on the diameter and alignment of poly(hydroxybutyrate-co-hydroxyvalerate) fibers
| Title | An investigation into the influence of electrospinning parameters on the diameter and alignment of poly(hydroxybutyrate-co-hydroxyvalerate) fibers | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Tong, HW1 Wang, M1 | ||||||
| Keywords | biodegradable biofibers biomimetic electrospinning tissue engineering scaffold | ||||||
| Issue Date | 2011 | ||||||
| Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-8995/ | ||||||
| Citation | Journal Of Applied Polymer Science, 2011, v. 120 n. 3, p. 1694-1706 [How to Cite?] DOI: http://dx.doi.org/10.1002/app.33302 | ||||||
| Abstract | Electrospinning is an effective technology for the fabrication of ultrafine fibers, which can be the basic component of a tissue engineering scaffold. In tissue engineering, because cells seeded on fibrous scaffolds with varying fiber diameters and morphologies exhibit different responses, it is critical to control these characteristics of electrospun fibers. The diameter and morphology of electrospun fibers can be influenced by many processing parameters (e.g., electrospinning voltage, needle inner diameter, solution feeding rate, rotational speed of the fiber-collecting cylinder, and working distance) and solution properties (polymer solution concentration and conductivity). In this study, a factorial design approach was used to systematically investigate the degree of influence of each of these parameters on fiber diameter, degree of fiber alignment, and their possible synergetic effects, using a natural biodegradable polymer, poly(hydroxybutyrate-co-hydroxyvalerate), for the electrospinning experiments. It was found that the solution concentration invoked the highest main effect on fiber diameter, whereas both rotational speed of the fiber-collecting cylinder and addition of a conductivity-enhancing salt could significantly affect the degree of fiber alignment. By carefully controlling the electrospinning parameters and solution properties, fibrous scaffolds of desired characteristics could be made to meet the requirements of different tissue engineering applications. © 2010 Wiley Periodicals, Inc. | ||||||
| ISSN | 0021-8995 2011 Impact Factor: 1.289 2011 SCImago Journal Rankings: 0.077 | ||||||
| DOI | http://dx.doi.org/10.1002/app.33302 | ||||||
| ISI Accession Number ID | WOS:000288142700058
Funding Information: Contract grant sponsor: The University of Hong Kong (HKU). | ||||||
| References | References in Scopus |
| dc.contributor.author | Tong, HW | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Wang, M | ||||||
| dc.date.accessioned | 2011-08-26T14:23:27Z | ||||||
| dc.date.available | 2011-08-26T14:23:27Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Electrospinning is an effective technology for the fabrication of ultrafine fibers, which can be the basic component of a tissue engineering scaffold. In tissue engineering, because cells seeded on fibrous scaffolds with varying fiber diameters and morphologies exhibit different responses, it is critical to control these characteristics of electrospun fibers. The diameter and morphology of electrospun fibers can be influenced by many processing parameters (e.g., electrospinning voltage, needle inner diameter, solution feeding rate, rotational speed of the fiber-collecting cylinder, and working distance) and solution properties (polymer solution concentration and conductivity). In this study, a factorial design approach was used to systematically investigate the degree of influence of each of these parameters on fiber diameter, degree of fiber alignment, and their possible synergetic effects, using a natural biodegradable polymer, poly(hydroxybutyrate-co-hydroxyvalerate), for the electrospinning experiments. It was found that the solution concentration invoked the highest main effect on fiber diameter, whereas both rotational speed of the fiber-collecting cylinder and addition of a conductivity-enhancing salt could significantly affect the degree of fiber alignment. By carefully controlling the electrospinning parameters and solution properties, fibrous scaffolds of desired characteristics could be made to meet the requirements of different tissue engineering applications. © 2010 Wiley Periodicals, Inc. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Journal Of Applied Polymer Science, 2011, v. 120 n. 3, p. 1694-1706 [How to Cite?] DOI: http://dx.doi.org/10.1002/app.33302 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1002/app.33302 | ||||||
| dc.identifier.epage | 1706 | ||||||
| dc.identifier.hkuros | 189906 | ||||||
| dc.identifier.isi | WOS:000288142700058
Funding Information: Contract grant sponsor: The University of Hong Kong (HKU). | ||||||
| dc.identifier.issn | 0021-8995 2011 Impact Factor: 1.289 2011 SCImago Journal Rankings: 0.077 | ||||||
| dc.identifier.issue | 3 | ||||||
| dc.identifier.scopus | eid_2-s2.0-79551697517 | ||||||
| dc.identifier.spage | 1694 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/137334 | ||||||
| dc.identifier.volume | 120 | ||||||
| dc.language | eng | ||||||
| dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-8995/ | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Journal of Applied Polymer Science | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Journal of Applied Polymer Science. Copyright © John Wiley & Sons, Inc. | ||||||
| dc.subject | biodegradable | ||||||
| dc.subject | biofibers | ||||||
| dc.subject | biomimetic | ||||||
| dc.subject | electrospinning | ||||||
| dc.subject | tissue engineering scaffold | ||||||
| dc.title | An investigation into the influence of electrospinning parameters on the diameter and alignment of poly(hydroxybutyrate-co-hydroxyvalerate) fibers | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong