File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: An investigation into the influence of electrospinning parameters on the diameter and alignment of poly(hydroxybutyrate-co-hydroxyvalerate) fibers

TitleAn investigation into the influence of electrospinning parameters on the diameter and alignment of poly(hydroxybutyrate-co-hydroxyvalerate) fibers
Authors
Keywordsbiodegradable
biofibers
biomimetic
electrospinning
tissue engineering scaffold
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-8995/
Citation
Journal Of Applied Polymer Science, 2011, v. 120 n. 3, p. 1694-1706 How to Cite?
AbstractElectrospinning is an effective technology for the fabrication of ultrafine fibers, which can be the basic component of a tissue engineering scaffold. In tissue engineering, because cells seeded on fibrous scaffolds with varying fiber diameters and morphologies exhibit different responses, it is critical to control these characteristics of electrospun fibers. The diameter and morphology of electrospun fibers can be influenced by many processing parameters (e.g., electrospinning voltage, needle inner diameter, solution feeding rate, rotational speed of the fiber-collecting cylinder, and working distance) and solution properties (polymer solution concentration and conductivity). In this study, a factorial design approach was used to systematically investigate the degree of influence of each of these parameters on fiber diameter, degree of fiber alignment, and their possible synergetic effects, using a natural biodegradable polymer, poly(hydroxybutyrate-co-hydroxyvalerate), for the electrospinning experiments. It was found that the solution concentration invoked the highest main effect on fiber diameter, whereas both rotational speed of the fiber-collecting cylinder and addition of a conductivity-enhancing salt could significantly affect the degree of fiber alignment. By carefully controlling the electrospinning parameters and solution properties, fibrous scaffolds of desired characteristics could be made to meet the requirements of different tissue engineering applications. © 2010 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/137334
ISSN
2014 Impact Factor: 1.768
2014 SCImago Journal Rankings: 0.611
ISI Accession Number ID
Funding AgencyGrant Number
The University of Hong Kong (HKU)
Research Grants Council of Hong KongHKU 7176/08E
Funding Information:

Contract grant sponsor: The University of Hong Kong (HKU).

References

 

DC FieldValueLanguage
dc.contributor.authorTong, HWen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2011-08-26T14:23:27Z-
dc.date.available2011-08-26T14:23:27Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Applied Polymer Science, 2011, v. 120 n. 3, p. 1694-1706en_HK
dc.identifier.issn0021-8995en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137334-
dc.description.abstractElectrospinning is an effective technology for the fabrication of ultrafine fibers, which can be the basic component of a tissue engineering scaffold. In tissue engineering, because cells seeded on fibrous scaffolds with varying fiber diameters and morphologies exhibit different responses, it is critical to control these characteristics of electrospun fibers. The diameter and morphology of electrospun fibers can be influenced by many processing parameters (e.g., electrospinning voltage, needle inner diameter, solution feeding rate, rotational speed of the fiber-collecting cylinder, and working distance) and solution properties (polymer solution concentration and conductivity). In this study, a factorial design approach was used to systematically investigate the degree of influence of each of these parameters on fiber diameter, degree of fiber alignment, and their possible synergetic effects, using a natural biodegradable polymer, poly(hydroxybutyrate-co-hydroxyvalerate), for the electrospinning experiments. It was found that the solution concentration invoked the highest main effect on fiber diameter, whereas both rotational speed of the fiber-collecting cylinder and addition of a conductivity-enhancing salt could significantly affect the degree of fiber alignment. By carefully controlling the electrospinning parameters and solution properties, fibrous scaffolds of desired characteristics could be made to meet the requirements of different tissue engineering applications. © 2010 Wiley Periodicals, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-8995/en_HK
dc.relation.ispartofJournal of Applied Polymer Scienceen_HK
dc.rightsJournal of Applied Polymer Science. Copyright © John Wiley & Sons, Inc.-
dc.subjectbiodegradableen_HK
dc.subjectbiofibersen_HK
dc.subjectbiomimeticen_HK
dc.subjectelectrospinningen_HK
dc.subjecttissue engineering scaffolden_HK
dc.titleAn investigation into the influence of electrospinning parameters on the diameter and alignment of poly(hydroxybutyrate-co-hydroxyvalerate) fibersen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/app.33302en_HK
dc.identifier.scopuseid_2-s2.0-79551697517en_HK
dc.identifier.hkuros189906en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79551697517&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume120en_HK
dc.identifier.issue3en_HK
dc.identifier.spage1694en_HK
dc.identifier.epage1706en_HK
dc.identifier.isiWOS:000288142700058-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTong, HW=23476100900en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats