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Article: An investigation into the influence of electrospinning parameters on the diameter and alignment of poly(hydroxybutyrate-co-hydroxyvalerate) fibers
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TitleAn investigation into the influence of electrospinning parameters on the diameter and alignment of poly(hydroxybutyrate-co-hydroxyvalerate) fibers
 
AuthorsTong, HW1
Wang, M1
 
Keywordsbiodegradable
biofibers
biomimetic
electrospinning
tissue engineering scaffold
 
Issue Date2011
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-8995/
 
CitationJournal Of Applied Polymer Science, 2011, v. 120 n. 3, p. 1694-1706 [How to Cite?]
DOI: http://dx.doi.org/10.1002/app.33302
 
AbstractElectrospinning is an effective technology for the fabrication of ultrafine fibers, which can be the basic component of a tissue engineering scaffold. In tissue engineering, because cells seeded on fibrous scaffolds with varying fiber diameters and morphologies exhibit different responses, it is critical to control these characteristics of electrospun fibers. The diameter and morphology of electrospun fibers can be influenced by many processing parameters (e.g., electrospinning voltage, needle inner diameter, solution feeding rate, rotational speed of the fiber-collecting cylinder, and working distance) and solution properties (polymer solution concentration and conductivity). In this study, a factorial design approach was used to systematically investigate the degree of influence of each of these parameters on fiber diameter, degree of fiber alignment, and their possible synergetic effects, using a natural biodegradable polymer, poly(hydroxybutyrate-co-hydroxyvalerate), for the electrospinning experiments. It was found that the solution concentration invoked the highest main effect on fiber diameter, whereas both rotational speed of the fiber-collecting cylinder and addition of a conductivity-enhancing salt could significantly affect the degree of fiber alignment. By carefully controlling the electrospinning parameters and solution properties, fibrous scaffolds of desired characteristics could be made to meet the requirements of different tissue engineering applications. © 2010 Wiley Periodicals, Inc.
 
ISSN0021-8995
2013 Impact Factor: 1.640
 
DOIhttp://dx.doi.org/10.1002/app.33302
 
ISI Accession Number IDWOS:000288142700058
Funding AgencyGrant Number
The University of Hong Kong (HKU)
Research Grants Council of Hong KongHKU 7176/08E
Funding Information:

Contract grant sponsor: The University of Hong Kong (HKU).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTong, HW
 
dc.contributor.authorWang, M
 
dc.date.accessioned2011-08-26T14:23:27Z
 
dc.date.available2011-08-26T14:23:27Z
 
dc.date.issued2011
 
dc.description.abstractElectrospinning is an effective technology for the fabrication of ultrafine fibers, which can be the basic component of a tissue engineering scaffold. In tissue engineering, because cells seeded on fibrous scaffolds with varying fiber diameters and morphologies exhibit different responses, it is critical to control these characteristics of electrospun fibers. The diameter and morphology of electrospun fibers can be influenced by many processing parameters (e.g., electrospinning voltage, needle inner diameter, solution feeding rate, rotational speed of the fiber-collecting cylinder, and working distance) and solution properties (polymer solution concentration and conductivity). In this study, a factorial design approach was used to systematically investigate the degree of influence of each of these parameters on fiber diameter, degree of fiber alignment, and their possible synergetic effects, using a natural biodegradable polymer, poly(hydroxybutyrate-co-hydroxyvalerate), for the electrospinning experiments. It was found that the solution concentration invoked the highest main effect on fiber diameter, whereas both rotational speed of the fiber-collecting cylinder and addition of a conductivity-enhancing salt could significantly affect the degree of fiber alignment. By carefully controlling the electrospinning parameters and solution properties, fibrous scaffolds of desired characteristics could be made to meet the requirements of different tissue engineering applications. © 2010 Wiley Periodicals, Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Applied Polymer Science, 2011, v. 120 n. 3, p. 1694-1706 [How to Cite?]
DOI: http://dx.doi.org/10.1002/app.33302
 
dc.identifier.doihttp://dx.doi.org/10.1002/app.33302
 
dc.identifier.epage1706
 
dc.identifier.hkuros189906
 
dc.identifier.isiWOS:000288142700058
Funding AgencyGrant Number
The University of Hong Kong (HKU)
Research Grants Council of Hong KongHKU 7176/08E
Funding Information:

Contract grant sponsor: The University of Hong Kong (HKU).

 
dc.identifier.issn0021-8995
2013 Impact Factor: 1.640
 
dc.identifier.issue3
 
dc.identifier.scopuseid_2-s2.0-79551697517
 
dc.identifier.spage1694
 
dc.identifier.urihttp://hdl.handle.net/10722/137334
 
dc.identifier.volume120
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-8995/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Applied Polymer Science
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Applied Polymer Science. Copyright © John Wiley & Sons, Inc.
 
dc.subjectbiodegradable
 
dc.subjectbiofibers
 
dc.subjectbiomimetic
 
dc.subjectelectrospinning
 
dc.subjecttissue engineering scaffold
 
dc.titleAn investigation into the influence of electrospinning parameters on the diameter and alignment of poly(hydroxybutyrate-co-hydroxyvalerate) fibers
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong