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Article: Interleukin 17a promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression

TitleInterleukin 17a promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 7 How to Cite?
AbstractBackground: IL-17A is a pro-inflammatory cytokine that plays important role in inflammatory disease pathology and tumor microenvironment. The aim of this study is to investigate the effect of IL-17A on the progression of hepatocellular carcinoma (HCC). Methodology and Principal Finding: Expression pattern of IL-17A in clinical HCC samples (n = 43) was determined by immunohistochemistry staining. Transcript levels of MMP2, MMP9 and IL-17A were measured in another 50 pairs (including tumor and related non-tumor tissues) HCC samples. Cell growth, focus formation, cell migration, invasion and western blot assays were used to characterize the functional and signaling mechanisms in IL-17A-treated HCC. Association study was used to identify clinical significance of IL-17A in HCC. Compared with paired non-tumor tissue, higher frequency of IL-17A-positive cells was detected in tumor tissues in HCCs with metastasis, and the frequency of IL-17A-positive cells was also significantly associated with poor prognosis of HCC (P = 0.01). Functional study found that IL-17A could promote HCC cell migration and invasion. Further molecular analysis also showed that IL-17A could upregulate MMP2 and MMP9 expression via NF-κB signaling activation. Conclusions: IL-17A could promote HCC metastasis by the upregulation of MMP2 and MMP9 expression via activating NF-κB signaling pathway. © 2011 Li et al.
Persistent Identifierhttp://hdl.handle.net/10722/137273
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU 7656/07M
Hong Kong RGCHKU5/CRF/08
HKU7/CRG09
Sun Yat-sen University85000-3171311
Funding Information:

This work was supported by a Hong Kong Research Grant Council Grant (HKU 7656/07M), Hong Kong RGC Collaborative Research Grants (HKU5/CRF/08 and HKU7/CRG09) and the "Hundred Talents Program'' at Sun Yat-sen University (85000-3171311). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References
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DC FieldValueLanguage
dc.contributor.authorLi, Jen_HK
dc.contributor.authorLau, GKKen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorDong, Ssen_HK
dc.contributor.authorLan, HYen_HK
dc.contributor.authorHuang, XRen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorYuan, YFen_HK
dc.contributor.authorGuan, Xyen_HK
dc.date.accessioned2011-08-26T14:22:19Z-
dc.date.available2011-08-26T14:22:19Z-
dc.date.issued2011en_HK
dc.identifier.citationPlos One, 2011, v. 6 n. 7en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137273-
dc.description.abstractBackground: IL-17A is a pro-inflammatory cytokine that plays important role in inflammatory disease pathology and tumor microenvironment. The aim of this study is to investigate the effect of IL-17A on the progression of hepatocellular carcinoma (HCC). Methodology and Principal Finding: Expression pattern of IL-17A in clinical HCC samples (n = 43) was determined by immunohistochemistry staining. Transcript levels of MMP2, MMP9 and IL-17A were measured in another 50 pairs (including tumor and related non-tumor tissues) HCC samples. Cell growth, focus formation, cell migration, invasion and western blot assays were used to characterize the functional and signaling mechanisms in IL-17A-treated HCC. Association study was used to identify clinical significance of IL-17A in HCC. Compared with paired non-tumor tissue, higher frequency of IL-17A-positive cells was detected in tumor tissues in HCCs with metastasis, and the frequency of IL-17A-positive cells was also significantly associated with poor prognosis of HCC (P = 0.01). Functional study found that IL-17A could promote HCC cell migration and invasion. Further molecular analysis also showed that IL-17A could upregulate MMP2 and MMP9 expression via NF-κB signaling activation. Conclusions: IL-17A could promote HCC metastasis by the upregulation of MMP2 and MMP9 expression via activating NF-κB signaling pathway. © 2011 Li et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarcinoma, Hepatocellular - enzymology - genetics - pathology-
dc.subject.meshInterleukin-17 - pharmacology-
dc.subject.meshLiver Neoplasms - enzymology - genetics - pathology-
dc.subject.meshMatrix Metalloproteinase 2 - biosynthesis - genetics-
dc.subject.meshMatrix Metalloproteinase 9 - biosynthesis - genetics-
dc.titleInterleukin 17a promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expressionen_HK
dc.typeArticleen_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.emailGuan, Xy: xyguan@hkucc.hku.hken_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.identifier.authorityGuan, Xy=rp00454en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0021816en_HK
dc.identifier.pmid21760911-
dc.identifier.pmcidPMC3131399-
dc.identifier.scopuseid_2-s2.0-79960061468en_HK
dc.identifier.hkuros190890en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960061468&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue7en_HK
dc.identifier.spagee21816en_US
dc.identifier.epagee21816en_US
dc.identifier.isiWOS:000292655400021-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectLiver Transplantation Research Centre: A Multidisciplinary Study for Liver Graft Injury-
dc.identifier.scopusauthoridLi, J=47161271500en_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK
dc.identifier.scopusauthoridChen, L=23569135400en_HK
dc.identifier.scopusauthoridDong, Ss=35788109500en_HK
dc.identifier.scopusauthoridLan, HY=24544799000en_HK
dc.identifier.scopusauthoridHuang, XR=7410248090en_HK
dc.identifier.scopusauthoridLi, Y=36078298200en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridYuan, YF=7402708979en_HK
dc.identifier.scopusauthoridGuan, Xy=7201463221en_HK

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