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Article: The effect of the extracellular domain of human copper transporter (hCTR1) on cisplatin activation

TitleThe effect of the extracellular domain of human copper transporter (hCTR1) on cisplatin activation
Authors
Keywordsamino acids
antitumor agents
cisplatin
isotopic labeling
platinum
Issue Date2011
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie - International Edition, 2011, v. 50 n. 12, p. 2706-2711 How to Cite?
AbstractContractually binding: The methionine residues of the extracellular domain of hCTR1 (hCTR1-N) and its mutants were shown to be the key residues for cisplatin binding. hCTR1-N significantly facilitates the activation of the drug by the formation of Pt-thioether species. The anticancer drug is likely transported by hCTR1 through methionine-based sulfur-sulfur exchange (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/137218
ISSN
2015 Impact Factor: 11.709
2015 SCImago Journal Rankings: 6.229
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Xen_HK
dc.contributor.authorDu, Xen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorChan, DSBen_HK
dc.contributor.authorSun, Hen_HK
dc.date.accessioned2011-08-26T14:19:13Z-
dc.date.available2011-08-26T14:19:13Z-
dc.date.issued2011en_HK
dc.identifier.citationAngewandte Chemie - International Edition, 2011, v. 50 n. 12, p. 2706-2711en_HK
dc.identifier.issn1433-7851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137218-
dc.description.abstractContractually binding: The methionine residues of the extracellular domain of hCTR1 (hCTR1-N) and its mutants were shown to be the key residues for cisplatin binding. hCTR1-N significantly facilitates the activation of the drug by the formation of Pt-thioether species. The anticancer drug is likely transported by hCTR1 through methionine-based sulfur-sulfur exchange (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/homeen_HK
dc.relation.ispartofAngewandte Chemie - International Editionen_HK
dc.subjectamino acidsen_HK
dc.subjectantitumor agentsen_HK
dc.subjectcisplatinen_HK
dc.subjectisotopic labelingen_HK
dc.subjectplatinumen_HK
dc.subject.meshAntineoplastic Agents - pharmacology-
dc.subject.meshCation Transport Proteins - chemistry - metabolism-
dc.subject.meshCisplatin - pharmacology-
dc.subject.meshKinetics-
dc.subject.meshProtein Structure, Tertiary-
dc.titleThe effect of the extracellular domain of human copper transporter (hCTR1) on cisplatin activationen_HK
dc.typeArticleen_HK
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_HK
dc.identifier.authoritySun, H=rp00777en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201006739en_HK
dc.identifier.pmid21387471-
dc.identifier.scopuseid_2-s2.0-79952500898en_HK
dc.identifier.hkuros189460en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952500898&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2706en_HK
dc.identifier.epage2711en_HK
dc.identifier.eissn1521-3773-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridWang, X=35333341400en_HK
dc.identifier.scopusauthoridDu, X=37062963400en_HK
dc.identifier.scopusauthoridLi, H=37063577200en_HK
dc.identifier.scopusauthoridChan, DSB=35267881600en_HK
dc.identifier.scopusauthoridSun, H=7404827446en_HK
dc.identifier.citeulike10200631-

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