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Article: Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain
Title | Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain | ||||||||
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Authors | |||||||||
Keywords | Anterior mesendoderm Mouse forebrain Procollagen IIA Sonic hedgehog | ||||||||
Issue Date | 2010 | ||||||||
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417 | ||||||||
Citation | Developmental Dynamics, 2010, v. 239 n. 9, p. 2319-2329 How to Cite? | ||||||||
Abstract | Morphogenesis of the mammalian forebrain is influenced by the patterning activity of signals emanating from the anterior mesendoderm. In this study, we show that procollagen IIA (IIA), an isoform of the cartilage extracellular matrix protein encoded by an alternatively spliced transcript of Col2a1, is expressed in the prechordal plate and the anterior definitive endoderm. In the absence of IIA activity, the null mutants displayed a partially penetrant phenotype of loss of head tissues, holoprosencephaly, and loss of mid-facial structures, which is associated with reduced sonic hedgehog (Shh) expression in the prechordal mesoderm. Genetic interaction studies reveal that IIA function in forebrain and face development does not involve bone morphogenetic protein receptor 1A (BMPR1A)- or NODAL-mediated signaling activity. © 2010 Wiley-Liss, Inc. | ||||||||
Persistent Identifier | http://hdl.handle.net/10722/137208 | ||||||||
ISSN | 2023 Impact Factor: 2.0 2023 SCImago Journal Rankings: 0.917 | ||||||||
ISI Accession Number ID |
Funding Information: Grant sponsor Arthritis & Rheumatism Campaign (UK); Grant sponsor. the Research Grants Council and University Grants Council of Hong Kong SAR, Grant numbers HKU7275/00M, HKU7696/05M, AoE/M 04/04, Grant sponsor NHMRC of Australia, Grant number 372102 | ||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, AWL | en_HK |
dc.contributor.author | Wong, SYY | en_HK |
dc.contributor.author | Chan, D | en_HK |
dc.contributor.author | Tam, PPL | en_HK |
dc.contributor.author | Cheah, KSE | en_HK |
dc.date.accessioned | 2011-08-26T14:18:54Z | - |
dc.date.available | 2011-08-26T14:18:54Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Developmental Dynamics, 2010, v. 239 n. 9, p. 2319-2329 | en_HK |
dc.identifier.issn | 1058-8388 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/137208 | - |
dc.description.abstract | Morphogenesis of the mammalian forebrain is influenced by the patterning activity of signals emanating from the anterior mesendoderm. In this study, we show that procollagen IIA (IIA), an isoform of the cartilage extracellular matrix protein encoded by an alternatively spliced transcript of Col2a1, is expressed in the prechordal plate and the anterior definitive endoderm. In the absence of IIA activity, the null mutants displayed a partially penetrant phenotype of loss of head tissues, holoprosencephaly, and loss of mid-facial structures, which is associated with reduced sonic hedgehog (Shh) expression in the prechordal mesoderm. Genetic interaction studies reveal that IIA function in forebrain and face development does not involve bone morphogenetic protein receptor 1A (BMPR1A)- or NODAL-mediated signaling activity. © 2010 Wiley-Liss, Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417 | en_HK |
dc.relation.ispartof | Developmental Dynamics | en_HK |
dc.rights | Developmental Dynamics. Copyright © John Wiley & Sons, Inc. | en_US |
dc.subject | Anterior mesendoderm | en_HK |
dc.subject | Mouse forebrain | en_HK |
dc.subject | Procollagen IIA | en_HK |
dc.subject | Sonic hedgehog | en_HK |
dc.subject.mesh | Collagen Type II - genetics - metabolism | - |
dc.subject.mesh | Endoderm - metabolism | - |
dc.subject.mesh | Mesoderm - metabolism | - |
dc.subject.mesh | Procollagen - genetics - metabolism | - |
dc.subject.mesh | Prosencephalon - anatomy and histology - embryology | - |
dc.title | Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chan, D:chand@hkucc.hku.hk | en_HK |
dc.identifier.email | Cheah, KSE:hrmbdkc@hku.hk | en_HK |
dc.identifier.authority | Chan, D=rp00540 | en_HK |
dc.identifier.authority | Cheah, KSE=rp00342 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/dvdy.22366 | en_HK |
dc.identifier.pmid | 20730911 | - |
dc.identifier.scopus | eid_2-s2.0-77956291598 | en_HK |
dc.identifier.hkuros | 184370 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77956291598&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 239 | en_HK |
dc.identifier.issue | 9 | en_HK |
dc.identifier.spage | 2319 | en_HK |
dc.identifier.epage | 2329 | en_HK |
dc.identifier.eissn | 1097-0177 | - |
dc.identifier.isi | WOS:000281724800001 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Leung, AWL=37031536900 | en_HK |
dc.identifier.scopusauthorid | Wong, SYY=37032336400 | en_HK |
dc.identifier.scopusauthorid | Chan, D=7402216545 | en_HK |
dc.identifier.scopusauthorid | Tam, PPL=7202539412 | en_HK |
dc.identifier.scopusauthorid | Cheah, KSE=35387746200 | en_HK |
dc.identifier.issnl | 1058-8388 | - |