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Article: Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain

TitleLoss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain
Authors
KeywordsAnterior mesendoderm
Mouse forebrain
Procollagen IIA
Sonic hedgehog
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417
Citation
Developmental Dynamics, 2010, v. 239 n. 9, p. 2319-2329 How to Cite?
AbstractMorphogenesis of the mammalian forebrain is influenced by the patterning activity of signals emanating from the anterior mesendoderm. In this study, we show that procollagen IIA (IIA), an isoform of the cartilage extracellular matrix protein encoded by an alternatively spliced transcript of Col2a1, is expressed in the prechordal plate and the anterior definitive endoderm. In the absence of IIA activity, the null mutants displayed a partially penetrant phenotype of loss of head tissues, holoprosencephaly, and loss of mid-facial structures, which is associated with reduced sonic hedgehog (Shh) expression in the prechordal mesoderm. Genetic interaction studies reveal that IIA function in forebrain and face development does not involve bone morphogenetic protein receptor 1A (BMPR1A)- or NODAL-mediated signaling activity. © 2010 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/137208
ISSN
2015 Impact Factor: 2.198
2015 SCImago Journal Rankings: 1.726
ISI Accession Number ID
Funding AgencyGrant Number
Arthritis & Rheumatism Campaign (UK)
Research Grants Council and University Grants Council of Hong Kong SARHKU7275/00M
HKU7696/05M
AoE/M 04/04
NHMRC of Australia372102
Funding Information:

Grant sponsor Arthritis & Rheumatism Campaign (UK); Grant sponsor. the Research Grants Council and University Grants Council of Hong Kong SAR, Grant numbers HKU7275/00M, HKU7696/05M, AoE/M 04/04, Grant sponsor NHMRC of Australia, Grant number 372102

References

 

DC FieldValueLanguage
dc.contributor.authorLeung, AWLen_HK
dc.contributor.authorWong, SYYen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorTam, PPLen_HK
dc.contributor.authorCheah, KSEen_HK
dc.date.accessioned2011-08-26T14:18:54Z-
dc.date.available2011-08-26T14:18:54Z-
dc.date.issued2010en_HK
dc.identifier.citationDevelopmental Dynamics, 2010, v. 239 n. 9, p. 2319-2329en_HK
dc.identifier.issn1058-8388en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137208-
dc.description.abstractMorphogenesis of the mammalian forebrain is influenced by the patterning activity of signals emanating from the anterior mesendoderm. In this study, we show that procollagen IIA (IIA), an isoform of the cartilage extracellular matrix protein encoded by an alternatively spliced transcript of Col2a1, is expressed in the prechordal plate and the anterior definitive endoderm. In the absence of IIA activity, the null mutants displayed a partially penetrant phenotype of loss of head tissues, holoprosencephaly, and loss of mid-facial structures, which is associated with reduced sonic hedgehog (Shh) expression in the prechordal mesoderm. Genetic interaction studies reveal that IIA function in forebrain and face development does not involve bone morphogenetic protein receptor 1A (BMPR1A)- or NODAL-mediated signaling activity. © 2010 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417en_HK
dc.relation.ispartofDevelopmental Dynamicsen_HK
dc.rightsDevelopmental Dynamics. Copyright © John Wiley & Sons, Inc.en_US
dc.subjectAnterior mesendodermen_HK
dc.subjectMouse forebrainen_HK
dc.subjectProcollagen IIAen_HK
dc.subjectSonic hedgehogen_HK
dc.subject.meshCollagen Type II - genetics - metabolism-
dc.subject.meshEndoderm - metabolism-
dc.subject.meshMesoderm - metabolism-
dc.subject.meshProcollagen - genetics - metabolism-
dc.subject.meshProsencephalon - anatomy and histology - embryology-
dc.titleLoss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrainen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, D:chand@hkucc.hku.hken_HK
dc.identifier.emailCheah, KSE:hrmbdkc@hku.hken_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/dvdy.22366en_HK
dc.identifier.pmid20730911-
dc.identifier.scopuseid_2-s2.0-77956291598en_HK
dc.identifier.hkuros184370en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956291598&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume239en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2319en_HK
dc.identifier.epage2329en_HK
dc.identifier.eissn1097-0177-
dc.identifier.isiWOS:000281724800001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, AWL=37031536900en_HK
dc.identifier.scopusauthoridWong, SYY=37032336400en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridTam, PPL=7202539412en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK

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